分化异常

This results seemingly indicate tnat the morphogenic potential of calli and 〓h〓 fo〓mation of abnormal shoots may be related to the degrees of the aber〓ation of chrome〓ome numbers.

这表明分化能力与染色体数的变异程度有关，另外芽中染色体数异常细胞的存在也许是一些芽发育成畸形苗的一个重要原因。

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

As a result of particularity growth of mammary gland, the relations between dysdifferentiation and breast tumor, Mammary gland was an extremely appropriate model to study the organogeny, the cell differentiation and the organ reparative regeneration.

由于乳腺自身发育的特殊性，以及异常分化与乳腺肿瘤的关系，乳腺是研究器官发生、细胞分化、器官修复再生等机理非常合适的模型。

Because divergence timing of the West Clade from the East Clade of S. japonica complex was estimated to be Aquitanian of Miocene (23 Ma), during which the mountains and plateau of Southwest China were formatted, the divergence of the West Clade from the East Clade of s. japonica complex was presumably correlated closely with the uplifting of mountains and plateau of Southwest China. The multiple variations of the West Clade of S.

西部集群居群间具有更大的遗传分化值和更大的遗传分化值变动范围，提示西部物理环境的复杂性导致更多的小区域隔离，小的基因流和更大的绝对成种速率，这与西部的物理环境的复杂性是相协调的，并且可能是造成西部山地高原地区生物多样性异常丰富的微观过程和机制。

17 cases well-differentiated / dedifferentiated liposarcoma MDM2 and CDK4 express difference unusually is 76% and 82%.

1.17例高分化／去分化脂肪肉瘤中MDM2和CDK4异常免疫表达分别为76％和82％。

Immunity table type 17 cases well-differentiated / dedifferentiated liposarcoma and MDM2 express difference unusually is 82% and 76%.

免疫表型17例高分化／去分化脂肪肉瘤中CDK4、MDM2异常表达分别为82％和76％。

On the termination date, the cultured explants were all examined by Western blot, HE and transmission electron microscope. Our results showed that after 12-days in culture, the cultivation treated with AS-ODN reduced the synthesis of AMBN and had a deformed dental cusp with thinner enamel matrix. Ultrastructure analyses showed that there was hardly any cisternae of the rough endoplasmic reticulum in the ameloblasts at the tip of the cusp of AS-ODN treatedexplants. However, on average the enamel matrix was thinner compared with that in the control group. Furthermore, the collagen fibers in extracellular matrix were found disorganized. These findings seemed to provide a direct experimental evidence that tended to indicate that the arrested AMBN translation in cultured tooth germs might result in the delay of the tooth development.

经用Western蛋白印迹检测表明，所设计的反义核酸对AMBN InRNA具有良好的封闭效果并成功阻断了牙胚对AMBN的表达；在缺乏AMBN情况下，与对照组相比，实验组牙胚在体外可以继续生长发育至钟状晚期，出现成釉细胞和成牙本质细胞的分化，成釉细胞可以分化成为分泌期型成釉细胞，胞浆中缺少合成蛋白质所必需的粗面内质网和高尔基氏体，缺乏溶酶体，表明对蛋白合成和脚的能力降低；实验组牙胚有牙尖形成和基质分泌，但牙尖形态异常，基质形成减少，牙尖周围基质最厚处为O.6卜m，明显薄于对照组的5.spin，基质中胶原纤维粗细不等，排列稀疏， 3 第四军医大学硕士学位论文未见钙化现象，充分证明了AMBN在牙胚发育中参与釉质基质形成和矿化过程，影响胶原纤维和牙本质基质的合成，促进成釉细胞对蛋白质的合成和釉质基质蛋白降解。

Previous studies manifested that gastroenteric tumorigenesis and development was accompanied with the mistuning of signalling pathway that regulated proliferation and differentiation of the normal stem cells.

已有研究还表明胃肠道肿瘤发生发展过程中常伴随着参与正常干细胞增殖和分化调控的信号传导通路失调，提示干细胞增殖分化调控异常与胃肠道肿瘤发生密切相关。

Results The abnormality rate of BAEP in 258 cases was 81.01%. The abnormal findings in BAEP included prolongation of PL and IPL of the wave Ⅰ、Ⅲ and Ⅴ,and undifferentiation or disappearance of the waveshape.

结果 258例患儿BAEP异常率为81.01%，异常主要表现为Ⅰ、Ⅲ、Ⅴ波潜伏期均延长，Ⅰ～Ⅴ波间期延长，波形分化不良或波形消失。

The abnormal findings in BAEP included prolongation of PL and IPL of the wave Ⅰ、Ⅲ and Ⅴ,and undifferentiation or disappearance of the waveshape.

结果 258例患儿BAEP异常率为81.01%，异常主要表现为Ⅰ、Ⅲ、Ⅴ波潜伏期均延长，Ⅰ～Ⅴ波间期延长，波形分化不良或波形消失。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。