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On postnatal Day 5, wild-type mice and mice lacking alpha2A-adrenoceptor (alpha2A-KO) or alpha2C-adrenoceptor subtypes (alpha2C-KO) were randomly assigned to receive dexmedetomidine (3 microg/kg) or phosphate-buffered saline intraperitoneally. Thirty minutes after the intraperitoneal injection, the glutamatergic agonist ibotenate (10 microg) was intracerebrally injected, producing transcortical necrosis and white matter lesions that mimic perinatal human hypoxic-like lesions.

将出生后5天的野生型大鼠和缺乏α2A(α2A-KO)或α2C(α2C-KO)肾上腺受体亚型的大鼠腹膜内随机注射右旋美托咪啶(3 μg/kg)或磷酸钠缓冲液。30分钟后,脑内注射10μg 谷氨酸激动剂 ibotenate ,产生类似围产期缺氧性皮质坏死和白质损伤。

Neurotrophin-3/neurotrophic factor 3 is the important member of neurotrophin family, which can prevent embryonic and postnatal motoneuron death, maintain neuron survival, promote reparation and regeneration after nervous injury, and regulate synapse activity of neuron.

神经元营养因子-3 (neurotrophin-3, NT-3),是神经营养因子家族的重要成员,具有阻止胚胎期及出生后运动神经元细胞死亡,维持神经元的存活及促进神经损伤后的修复与再生,并参与调节神经元突触活动的作用。

The child in question had developed eczema limited to the face at around one year of age. He had been breast-fed at birth, was switched to milk-based formula at four months, and started on solid foods at five months without problems. At the time, no food reactions or worsening of the atopic dermatitis due to food exposure was seen. At the age of three, his parents, who had read about a possible link between eczema and food allergy, took him to a naturopath, who used electrodermal skin testing to look for possible hypersensitivity.

有问题的儿童,大约一岁时发生局限於脸部的湿疹,出生后就接受哺乳,四个月后转为牛奶为主的配方,并在五个月后没有问题的情况下,开始食用固体食物;在这个时候,没有发生食物引起的反应以及因为食物而恶化的异位性皮肤炎;在三岁时,他的父母偶然间得知有关湿疹与食物过敏之间可能的关连,因而带这位男童接受自然疗法医师的电表皮皮肤试验,寻求可能的过敏反应。

With the aid of Merlin,a powerful magician,Uther took the form of the duke and so Igrayne became pregnant with Athtur,After Arthur was born, the magician Merlin gave hin to a man named Hector to be raised as Hector's own son, Arthur grew up without knowing that he was the son of the king,When Arthur was a young man ,his father ,Uther Pendragon,died.

亚瑟出生后,墨林把他交给一个叫赫克托的人,要他把亚瑟当自己的儿子抚养。亚瑟长大后并不知道自己的身世。

Unlike the general presumption, the sociability of those born in the 1980s and 1990s is not so high.

与人们的想像不同,"九0后"和"八0后"(九十年代和八十年代出生)人群的"趣商"并不高。

After the birth of my second child, I got a job at a restaurant. Having worked with an experienced waitress for a few days, I was allowed to wait tables on my own. All went well that first week.

托盘。 在我的第二个孩子出生后,我在一家餐馆有了一份工作,在跟了一个有经验的女服务员几天后,我得以自己开始服务,第一周一切顺利。

Results: 1 Intense ERα immunoreactivity localized in the hypertrophic and maturative layer, and some immunoreactivity was found in osteoblasts of mandible and temporal bone, while no immunoreactivity was found in the disc and synovium. 2 The expression of ERα in male rats TMJ cartilage was higher than that in female ones. 3 In the condyle cartilage of male rats, the density of ERα positive cells decreased with age, which kept stable after 16 weeks of age. 4 In the condyle cartilage of male rats, the density of ERα positive cells was stable from birth to 8 weeks, but decreased from 16 weeks to 12 months, while the density in 18-month group recovered to the level of 8 weeks. Conclusion: TMJ is one of target organs of estrogen, and ERα plays an important role in the effect of estrogen on TMJ.

结果:1TMJ中ERα主要在髁突软骨的肥大层和过渡层表达,下颌骨和颞骨的骨细胞也有少量表达,而关节盘、滑膜中几乎无表达;2雄性SD大鼠髁突软骨中ERα的表达明显强于同龄的雌性大鼠;3在雄性大鼠TMJ髁突软骨中阳性细胞密度随年龄增长逐渐降低,16周以后逐渐维持在相对稳定的水平;4雌性大鼠从出生后到8周龄阳性细胞密度基本稳定,在16周龄至12月龄年龄组阳性细胞密度显著降低,而在18月龄后又恢复到8周龄以前的水平。

During the first two weeks after birth, the growth performances were not significant between the mutant mice and the normal ones, but after that, the mutant mice grew much slower. The differences were significant in the indexes of eyes, lungs, thymuses, and adrenal glands between the genders. At the same time, the differences were significant in the organ indexes, such as lungs, adrenal glands, uterine and testicles between the normal phenotype mutant mice and the abnormal ones. And these two kinds of mice showed different amount of hemoglobin and red blood cell.

结果:B6-Co小鼠不育率22%、平均产仔数5.62±2.55只、离乳成活率56.59±41.22显著低于正常的B6小鼠,而胎间隔29.50±10.50天比正常B6小鼠短。B6-Co小鼠出生后2周内生长发育与正常B6小鼠基本一致,2周后,其生长发育慢于正常B6小鼠。B6-Co小鼠雌雄间的眼球、肺、胸腺、肾上腺的脏器指数差异有统计学意义。B6-Co表型异常小鼠与B6-Co表型正常小鼠相比,肺、肾上腺、子宫、睾丸的脏器系数差异有统计学意义。B6-Co小鼠表型异常小鼠在血红蛋白和红细胞数量上异于B6-Co表型正常小鼠。

Results: B6-Co mice showed higher sterile rate, and significant lower average litter size and survival rate at weaning than the normal B6 mice, but the time interval between deliveries was shorter in the mutant population. During the first two weeks after birth, the growth performances were not significant between the mutant mice and the normal ones, but after that, the mutant mice grew much slower. The differences were significant in the indexes of eyes, lungs, thymuses, and adrenal glands between the genders. At the same time, the differences were significant in the organ indexes, such as lungs, adrenal glands, uterine and testicles between the normal phenotype mutant mice and the abnormal ones. And these two kinds of mice showed different amount of hemoglobin and red blood cell.

结果:B6-Co小鼠不育率22%、平均产仔数5.62±2.55只、离乳成活率56.59±41.22显著低于正常的B6小鼠,而胎间隔29.50±10.50天比正常B6小鼠短。B6-Co小鼠出生后2周内生长发育与正常B6小鼠基本一致,2周后,其生长发育慢于正常B6小鼠。B6-Co小鼠雌雄间的眼球、肺、胸腺、肾上腺的脏器指数差异有统计学意义。B6-Co表型异常小鼠与B6-Co表型正常小鼠相比,肺、肾上腺、子宫、睾丸的脏器系数差异有统计学意义。B6-Co小鼠表型异常小鼠在血红蛋白和红细胞数量上异于B6-Co表型正常小鼠。

In the 248th year of the Diocletian Era (based on Diocletian's ascension to the Roman throne), Dionysius Exiguus attempted to pinpoint the number of years since Jesus' birth, arriving at a figure of 753 years after the founding of Rome.

在戴克理先时期的第248年(是基于戴克理先提升到罗马王座),耶稣出生后数年,戴奥尼夏试图去查明,在建立罗马后的753年,为其造像。

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In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国,慢性酒精中毒,肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题,你可以随时联系我。

Very pretty, but the airport looks more fascinating The other party wisecracked.

很漂亮,不过停机坪更迷人。那人俏皮地答道。