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Leucocytic differentiation antigen 40 sign-al access participates in regulation of inflammatory reaction accommodation of major cell component (vascular endothelial cell、vascular smooth muscle cell and macrophage), it is playing critical role in AS process, participates ather-osclerotic occurrence and development ,reside in atherosclerotic plaque cell thro-ugh CD40-CD40L interaction, induce activate by itself , express and secrete profit to happen immune response、inflammatory reaction、hemagglutination t-hrombogenic proteo-cytokine.

白细胞分化抗原40 (CD40)信号通路参与了动脉粥样硬化斑块内主要细胞成分(血管内皮细胞、血管平滑肌细胞以及巨噬细胞)炎症反应的调节,其在AS进程中扮演着关键性的角色,参与了动脉粥样硬化的发生和发展;存在于AS斑块内的细胞通过CD40-CD40L相互作用,导致自身活化,表达和分泌了有利于免疫应答发生、炎症反应、血凝和血栓形成的蛋白质细胞因子,如激活在AS斑块中的关键性细胞成分如黏附分子、炎症因子、基质金属蛋白酶等的产生,导致斑块的不稳定和破裂,而最终导致粥样硬化斑块病变的恶化。

When she jabs her proboscis into a person's epidermis to drink blood, she sprays the bite area with saliva that serves as an anticoagulant. If her last victim had malaria, that saliva will contain one-celled malaria parasites called plasmodia, a couple of dozen of which can enter the human bloodstream. But it only takes one to kill a person.

当按蚊的雌蚊猛刺进人的皮肤吸血时,还会喷射抗凝剂,假如它叮咬的是患有疟疾的病人,那么雌蚊也就把疟原虫吸进它的体内,然后她又去叮咬其它的人,又把雌蚊体内的疟原虫传播到另外的人造成新的疟疾病人。

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