凝血因子

The structures, functions and anticoagulant mechanisms of anticoagulation factors ACF I and ACF II from the venom of Agkistrodon acutus have been investigated. Both ACF I and ACF II form a 1:1 complex with activated coagulation factor X in a Calcium ion-dependent fashion which prevents the interaction of FXa with other proteins in the coagulation process, therefore ACF I and ACF II have marked anticoagulant activity.

中文摘要：对尖吻蝮蛇毒中抗凝血因子ACF I和ACF II的结构、功能和抗凝机理等进行了深入研究，发现ACF I和ACF II均与活化凝血因子X结合成1：1的复合物，从而阻止了FXa进一步参加凝血过程中反应，因而具有显著的抗凝血活性。

Both ACF I and ACF II form a 1:1 complex with activated coagulation factor X in a Calcium ion-dependent fashion which prevents the interaction of FXa with other proteins in the coagulation process, therefore ACF I and ACF II have marked anticoagulant activity.

对尖吻蝮蛇毒中抗凝血因子ACF I和ACF II的结构、功能和抗凝机理等进行了深入研究，发现ACF I和ACF II均与活化凝血因子X结合成1：1的复合物，从而阻止了FXa进一步参加凝血过程中反应，因而具有显著的抗凝血活性。

Objective To investigate the clinical feature,mechanism and therapy of primary amyloidosis with acquired factor Ⅶ deficiency.

目的 探讨原发性淀粉样变并发凝血因子Ⅶ缺乏的临床特征、发病机制及治疗方法。

Objective To study the level and clinical significance of plasm antithrombin III,factor VIII,fibrinogen and D-dimer in pregnancy.

目的研究抗凝血酶-Ⅲ、凝血因子Ⅷ活性、纤维蛋白原、D-二聚体四项血凝指标在妊娠中的变化，探讨其在妊高征诊断和预防中的价值。

We initially consider that a preoperative complete replacement of coagulation factors and platelet according to the coagulability tests may lessen intraoperative bleeding and transfusion and make the patient an uneventful postoperative course.

我们初步认为，根据凝血功能检查结果于术前就补充足够凝血因子和血小板，可减少术中出血和输血，患者术后恢复较顺利。

Methods Preoperative coagulability, the replacement therapy by coagulation factors and platelet pre-and intra-operatively, intra-operative bleeding amount and blood transfusion amount and the relation to the postoperative course were analyzed retrospectively in 6 patients with severe hepatic cirrhosis who underwent OLT in the last year.

回顾性分析我科1年来6例因重度肝硬变行OLT术前凝血功能、术前、术中凝血因子和血小板的补充、术中出血量和输血量与术后过程的关系。

Keywords: Agkistrodon acutus; Anticoagulation factor; Agkisacutacin; Hemorrhagin; Activated coagulation factor X

中文关键词：尖吻蝮蛇毒；抗凝血因子；抗血小板溶栓素；出血毒素；活化凝血因子X

Agkistrodon acutus; Anticoagulation factor; Agkisacutacin; Hemorrhagin; Activated coagulation factor X

中文主题词：尖吻蝮蛇毒；抗凝血因子；抗血小板溶栓素；出血毒素；活化凝血因子X

Patients suffer from low levels of plasma clotting factors . They are vulnerable to injuries: once a haemophiliac starts to bleed, there is no way to stop the bleeding except by an injection of the missing clotting factor. Without this timely injection, internal bleeding may cost the patient's life.

因为血液中缺乏凝血因子，患者不仅极易出血，且一旦出血就无法自行止住，内腔器官出血往往会致命，患者只能靠注射凝血因子止血。

The Chinese government should abolish the ban of imports of clotting factors, and should immediately import a large volume of clotting factor products. This will give Chinese haemophiliacs more options, and complement the shortage of domestic clotting factor production. In 1986, the Ministry of Health issued a circular to prohibit the import of Factor VIII and similar blood products to prevent the inflow of HIV/AIDS and other diseases.

我国政府应解除禁止进口国外凝血因子的政策，尽快引进国外的凝血因子制品，为血友病患者提供更多的选择余地，以弥补国内凝血因子产品供不应求的情况。1986年1月30日，卫生部发布《关于禁止进口Ⅷ因子等血液制品的通告》目的是阻止进口血液制品将艾滋病等传染病带入中国。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。