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Results:The etiologic mechanism of steroid-induced necrosis of femoral head is:Disorder of lipometabolism;increasing of intraosseous pressure;Osteoporosis and poisonous action;vasculitis,coagulation before steroid administration and intrava...

结果 :激素性股骨头缺血坏死存在如下发病机理:脂肪代谢紊乱;骨内压增加;骨质疏松及激素的毒性作用;血管炎、前凝血状况及血管内凝血

Results:The etiologic mechanism of steroid-induced necrosis of femoral head is:Disorder of lipometabolism;increasing of intraosseous pressure;Osteoporosis and poisonous action;vasculitis,coagulation before steroid administration and intravascular coagulation.

结果:激素性股骨头缺血坏死存在如下发病机理:脂肪代谢紊乱;骨内压增加;骨质疏松及激素的毒性作用;血管炎、前凝血状况及血管内凝血

Patients were randomly assigned to two groups, The one is chronic tonsillitis, the other was obstructive sleep apnea syndrome, Exclusion criteria of chronic tonsillitis included peritonsillar abscess history, bleeding disorders, and any other procedure together with tonsillectomy., Indications of chronic tonsillitis included intraoperative bleeding, operative time, postoperative pain, and return to normal diet were evaluated. Indications of obstructive sleep apnea syndrome included Intraoperative bleeding, operative time, Using spss11.0 software analyzed all the data.

实验设计和观察指标:选择慢性扁桃体炎患者30和鼾症患者30人,慢性扁桃体炎患者不包括伴随扁桃体周围脓肿患者,不包括有血液系统疾病和凝血障碍的患者,同时不包括扁桃体切除手术和其它手术同时进行的患者,鼾症患者不包括有血液系统疾病和凝血障碍患者,慢性扁桃体炎患者观察记录的指标包括手术时间﹑手术中出血量﹑术后疼痛时间和程度和正常饮食恢复时间,鼾症患者记录手术时间和手术中出血量,使用spss11.0软件对所有的数据进行描述性统计分析

Thirty patients with acute promyelocytic leukemia were observed between September 1977 and October 1985. Bleeding diathesis with petechiae or ecchymosis (80%) was the most common presenting symptom. Seventeen of 24 patients with pretreated coagulation studies were diagnosed to have disseminated intravascular coagulation. Six out of 11 patients died from intracranial hemorrhage after a mean of 2.5 days of hospitalization without any treatment. DIC was responsible for death in most cases. Induction therapy with anthracycline and cytosine arabinoside combined with prophylactic heparin infusion was carried out in the remaining 19 patients. Two patients were incompletely treated. Eight out of 17 patients achieved complete remission after a mean of 63 days following chemotherapy. The remission rate was 47%.

自1977年9月至1985年10月,观察30位急性前骨髓球性白血病病帣,临床上诊断时初发症状,主要为出血现象,尤其以瘀斑出血最多,占80%。24位病人作治疗前凝血机能检查,17位出现播散性血管内凝固症候群。11位病人没有接受治疗,其中6位经诊断后平均2.5天内死於脑内出血,凝血机能检验显示5位有播散性血管内凝固症候群。19位病人接受anthracycline与ara-C并用预防性肝素静脉滴注作缓解诱导治疗,2位不完全治疗,其余17位中有8位经过平均63天之化学治疗得到完全缓解,缓解率47%。

Coagulation dysfunction does exist in neonates with pneumorrhagia caused by scleredema and asphyxia. Plasma TXB2 and FPA should be considered as the early objective monitoring indices in neonates who are highly suspected as having pneumorrhagia .

新生儿肺出血患儿存在血小板活化和异常凝血;窒息和硬肿症所致的新生儿肺出血都存在止血凝血功能障碍这一共同因素;TXB2和FPA可作为预测新生儿肺出血的早期客观监测指标。

Coagulation dysfunction does exist in neonates with pneumorrhagia caused by scleredema and asphyxia. Plasma TXB2 and FPA should be considered as the early objective monitoring indices in neonates who are highly suspected as having pneumorrhagia . Lung diseases Infant, newborn Thromboxane B2 Fibrinopeptides A Hemorhage

新生儿肺出血患儿存在血小板活化和异常凝血;窒息和硬肿症所致的新生儿肺出血都存在止血凝血功能障碍这一共同因素;TXB2和FPA可作为预测新生儿肺出血的早期客观监测指标。

ConclusionsCoagulation dysfunction does exist in neonates with pneumorrhagia caused by scleredema and asphyxia. Plasma TXB2 and FPA should be considered as the early objective monitoring indices in neonates who are highly suspected as having pneumorrhagia.Key wordsLung diseasesInfant, newbornThromboxane B2Fibrinopeptides AHemorhage

结论新生儿肺出血患儿存在血小板活化和异常凝血;窒息和硬肿症所致的新生儿肺出血都存在止血凝血功能障碍这一共同因素;TXB2和FPA可作为预测新生儿肺出血的早期客观监测指标。

Disseminated intravascular coagulation is a consequence of widespread activation of the coagulation system through endothelial injury and/or release of thromboplastic substances into the circulation.

通过内皮损伤和/或释放促凝血物质进入血液循环使凝血系统被广泛激活是 DIC 产生的原因。

The change of agglutinating activity in different temperature and pH indicated that PML had no hemagglutinating activity at 80℃. The effect of chemical modification of amino acid residues upon hemagglutination was investigated. There was a definite decrease of fluorescence intensity which corresponds to the oxidation of tryptophan.

研究了不同温度、pH和变性剂对PML凝血活性的影响和荧光光谱的变化,当温度达80℃时,活性完全丧失;pH为4—9对活性影响不大,pH低于2和pH高于12时,大黑花芸豆凝集素的凝血活性大部分丧失;高温和强碱对荧光光谱有较大影响,表明PML对高温,强碱的耐受性不强。

Hemophilia B is an X-linked bleeding disease, caused by the mutations of human coagulation factor IX gene located in chromosome X. It results in a dramatic decline of hFIX quantity or clotting activity in plasma, and the intrinsic clotting pathway is affected seriously.

血友病B是一种性连锁隐性遗传病,其发病机制是位于X染色体上的人凝血因子IX基因发生了突变,导致血浆中hFIX含量或活性大幅下降,从而使得内源性凝血途径受到阻碍,无法进行正常的凝血

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