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Combined with animal model of peradaptation to myocardium ischemia , the research observed the level of enzymatic dynamics of myocardium, SOD,MDA,ET and correlation peptide of calcitonin gene in peripheral blood and cardiac function, apoptic cell and expression of apoptosis regulatory gene, ultrastructure of myocardium with BIOPAC16, in situ end labeling and hybridism, optic microscope and electron microscope. The study of animal model of peradaptation to myocardium ischemia illustrated that the peradaptation and pretreatment with Wenxin capsule could be positively protective for the injury of ischemia reperfusion. The protection is mainly reflected by reduction of infarction area, correction of heart rhythm abnormality of ischemia reperfusion, melioration of the contraction and relaxation function of myocardium, recovery of the subcellular structure and themelioration of the abnormality of biochemical and bioactive substance in the myocardium.

并结合心肌缺血预适应动物模型,采用BIOPAC16导生理记录和分析处理系统处理心肌功能指标,采用原位末端标记及原位杂交技术标记凋亡细胞及凋亡相关调控基因的表达,采用光电镜技术观察心肌超微结构的变化,同时观察外周血心肌酶、超氧化物歧化酶、丙二醛、内皮素、降钙素基因相关肽等水平,结果表明心肌缺血预适应及温心胶囊预处理对心肌缺血再灌注损伤具有肯定的保护作用,其保护心脏作用主要表现在缩小心肌梗死范围、抗缺血再灌注心律失常、改善心肌收缩和舒张功能、减轻心肌超微结构损伤,调节心肌生化物质及生物活性物质的生成和释放。

The degradating and redistributing of ECM were migration of VSMC and vascular remodeling through inhibiting the production of PDGF-BB and the activation of MMPs so to prevent the vascular stenosis.⑤Orthotopic hybridism in situ: The expression of MMP-3 increased after operation, the tendency and intensity were parallel to the expression of NF-κB. Tongxinluo could decrease the expression of MMP-3 and NF-κB. The study showed that the producting and activating of MMP-3 were modulated by NF-κB. The inhibition to the producting and activating of MMp-3 of Tongxinluo was mediated by inhibiting the activating of NF-κB. Conclusion ①The rabbit vascular stenosis model could be established successfully by plain balloon damage, the operation process was easy, economical and practical.

①单纯球囊损伤可成功建立典型家兔血管狭窄模型,操作方法简单,经济实用;②以VSMC增殖、迁移为主的内膜增厚以及以ECM降解、合成与再分布所致的血管重构是导致受损血管狭窄的根本原因;③通心络能明显抑制VSMC的增殖、迁移和ECM降解、合成,阻止血管内膜增生和血管重构,防止受损血管狭窄;该作用可能与其减少和阻止PDGF-BB的产生和活性,以及抑制MMPs的表达和恢复MMPs/TIMPs平衡有关;④通心络能显著抑制球囊损伤后血管内膜增生和血管重构,可能与其保护血管内皮,改善内皮功能,增加血清NO含量有关;⑤通心络抑制内膜增生和血管重构,减轻受损血管狭窄,还可能是通过抑制NF-κB的活化途径而起作用的。

Hydration is key to alleviating eczema ...

水化的关键是减轻湿疹。。。

In order to reduce the expense production,by using the design principle such as locally supllying strength and approximately equi-strength ,standing shield hydraulic support can be revamped as efficieatly shield hydraulic support.

为了降低生产成本,采用局部补强、近似等强度的设计原理,将支撑掩护式支架改造成掩护式支架,改造后的支架完全具备掩护式液压支架在强度方面和运行轨迹方面的要求,同时也达到了减轻支架自身的目标。

The pathologic changes were observed by light and electron microscope.Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性,并可见肝细胞坏死灶,姜黄素治疗组的肝细胞未见坏死改变,水样变性和脂肪变性程度减轻,以高剂量姜黄素组的治疗效果最为明显。

Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.Hepatocytes in curcumine treatment group showed no necrotic changes,and the degree of hydropic and fatty degeneration was markedly reduced,especially in the high-dose curcumine treatment group.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性,并可见肝细胞坏死灶,姜黄素治疗组的肝细胞未见坏死改变,水样变性和脂肪变性程度减轻,以高剂量姜黄素组的治疗效果最为明显。

Results:The main manifestation of A group was transient hepatocyte hydropic degeneration; in group B the degeneration of hepatocytes was most severe in the 2nd week. Fibrosis appeared in the 4th week,and obvious pseudolobules were formed in some parts of the liver in the 6th week.

结果:A组HE染色肝细胞呈一过性水样变,变性在2周时最重,至6周已明显减轻。B组HE染色2周时肝细胞明显水样变,4周时可见汇管区纤维组织增生,6周时部分肝组织出现明显假小叶结构。

The effect of diminishing labyrinth hydrops after opening and placing streptomycin on LSC has not been found.

未发现LSC开窗和开窗放置链霉素有明显减轻迷路积水的作用。

The study also found more evidence that ADHD symptoms change with ages, hyperactivity and lack of self-control decrease.

研究也发现了更多的证据表明ADHD的症状随年龄而变化,过度兴奋和不能自我控制都有所减轻

We concluded that NSAIDs reduced pain behavior and inflammation but had little effect on referred hyperalgesia.

NSAIDs 能减轻行为疼痛和炎症但对痛觉增敏的影响很小。

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In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是,在否定句或疑问句里,这种带有"do"的方法表达的效果却没有什么强调的意思。

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