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Result: The divided functional recipes of DHZCP could significantly decreased the deposit of lipid and the atherosclerotic plaque area in aorta intima, relieve the histopathological changes of atherosclerosis,and inhibited the proliferation of vascular smooth muscle cells and collagen to reduce pachynsis of vascular intima. The divided functional recipes of DHZCP also reduced IT, IMT and IT/MT and reversed the contractive vascular remodeling.

结果:大黄虫丸各功效组分均能减少家兔主动脉内膜脂质沉积,使AS斑块面积减小( P 。05);抑制血管平滑肌细胞增殖和胶原纤维增生,减轻内膜增厚;降低IT,IMT,IT/IMT比值( P 。05),干预收缩性血管重塑;减轻线粒体肿胀,减少泡沫样细胞形成。

objective to search the factors of liver injury via the anit-induced liver injury in rats.methods male sprague-dawley rats,were divided into 4 groups,data were analyzed using a completely randmized factorial anova and linear correlation.results after anit intoxication,the necrosis of hepatic cell and neutrophil infiltration im periportal region of the liver were observed in liver setions.jinshisan can reduce the alt,the tbil.pla2 correlated positively with alt、akp and tbil.conclusion the severity of anit-induced liver injury correlated positively with the pla2.jinshisan can protect against the rat anit-induced liver injury.

目的 拟通过对α-萘异硫氰酸酯诱导大鼠肝损伤发病机理的探讨,对引起肝损伤的因素进行系统的研究。方法选择s-d大鼠,雄性,随机分4组,检测数据以平均值±标准差表示,采用方差分析,相关分析进行统计学处理。结果s-d大鼠经anit染毒后,病理切片显示肝损伤明显,汇管区有大量中性粒细胞浸润。经金石散及地塞米松治疗后,生化指标均有所下降,中药金石散优于地塞米松,血生化指标与pla2活性相关分析显示,呈正相关。结论 anit诱导的肝毒性损伤程度与肝组织匀浆pla2活力呈正相关,应用抑制剂降低pla2活力,肝损伤程度也减轻,中药金石散具有降低pla2活性,减轻肝毒性损伤。

The drug of Xin xiebai powder can raise the content of SOD , at the same time reduce the content of the toxic oxygen free radicals and the injury by lipid peroxidate and lighten the lung damage by the oxidation effects of stress reaction.It confirms the security of Xin xiebai powder by acute toxic experiment.

能够提高机体 SOD 的含量,从而减轻毒性氧自由基的含量,降低机体内脂质过氧化,减轻氧化应激反应引起的肺损伤。

Pharmacologic therapy is used to prevent and control symptoms, reduce the frequency and severity of exacerbations, improve health status.

因此,寻找有效的治疗药物以减轻COPD的慢性炎症,改善肺功能,减轻气道重塑是目前医学界迫切需要解决的问题。

The mechanism of action maybe include the depression in content of collagen, inhibition to proliferation of lung fibroblast, action of anti free redical and anti lipid peroxidation, and elevation of content of GSH-PX.So we think phenol total base of plumula nelumbinis is a sort of promising drug to healing PF.

综上所述,我们认为莲子心酚性总碱可能对肺纤维化的病理过程有多靶点作用:前期通过抗自由基作用,从而减轻肺泡炎损伤:后期直接抑制肺成纤维细胞的增殖及蛋白沉积,减轻纤维化病变程度。

The results indicated that the mutant protein promoted the survival of dorsal root ganglion、induced TF-1 prolification and made the normal mice lose weight,decrease appetite and reduce fat index.The weight loss effect was dependant with its administration dosage,ED50 was 150.986?

结果是突变体蛋白能促进鸡胚背根神经节的生长;促进TF-1细胞增殖,MTT测定法表明突变体蛋白与国际参考品相比,比活不低于2.0×106U/mg;使正常小鼠的体重减轻,摄食量减少,脂肪指数下降,并且体重的减轻与突变体蛋白的给药剂量呈现良好的剂量依赖关系,其ED50为:150.986?

Simvastatin may suppress interstitial fibrosis by effect CTGF、suppress cell proliferation、redue extracellular matrix accumulation.

辛伐他汀可以抑制CTGF、抑制肾小管上皮细胞的转分化、减轻细胞外基质的积聚,从而减轻间质纤维化,发挥肾保护作用。

Results(1) Group of electroacupuncture in Shu and dense wave can significantlyreduce the degree of ankle swelling(P<0.05, P<0.01), which shows thatelectroacupuncture has obvious anti-inflammatory and repercussive roles;(2) Theresults of HE staining showed that group of electroacupuncture in Shuand dense wave can significantly reduce inflammatory cell infiltration,inhibit synovial cell proliferation, and decrease proliferation of granulationtissue in rats joints;(3) group of electroacupuncture in dense-wave can increase the pain thresholdof experimental rats (P<0.05, P<0.01), reduce the content of peripheral painmediums, such as K~+, DA and 5-HT(P<0.05, P<0.01), which shows thatelectroacupuncture has significant analgesic effect;(4) In the local lesion of joints, electroacupuncture can significantly reducethe content of IL-1β, IL-8, TNF-a, increase IL-4 content, decrease theexpression of COX-2mRNA, and significantly promote the expression ofHSP-70 protein in synovial tissues of acute gouty arthritis rats (P<0.05,P<0.01),thus restrain the occurrence of synovial tissue inflammation.

结果:(1)电针疏密波组能显著减轻踝关节肿胀度(P<0.05,P<0.01),表明电针有明显的抗炎消肿作用;(2)HE染色显示:电针疏密波组可使大鼠关节炎症细胞浸润明显减轻,滑膜细胞增生明显被抑制,肉芽组织增生明显减少;(3)电针密波组能提高实验性大鼠痛阈(P<0.05,P<0.01),降低外周疼痛介质K~+、DA、5-HT的含量(P<0.05,P<0.01),表明电针有明显的镇痛作用;(4)在病变关节局部,电针能显著降低急性痛风性关节炎大鼠滑膜组织IL-1β、IL-8、TNF-α含量(P<0.05,P<0.01),升高IL-4的含量(P<0.05,P<0.01),并降低关节滑膜内COX-2mRNA的表达(P<0.05,P<0.01),可促使急性痛风性关节炎大鼠滑膜内HSP-70蛋白表达显著增加(P<0.05,P<0.01),从而抑止滑膜组织炎症发生。

Induced abortion is the small operation of a short time, language communication has the limitation on time, it is the psychological state of the person that understand induced abortion, reduce anguish of its body and mind, the help eliminates undesirable mood, create optimal mentation, make the operation goes on wheels, the person that blame language communicates pair of induced abortion is having main effect. 1, the vision that uses attention, the mood of the person that riant expression stabilizes induced abortion, reduce their insecurity, scared psychology thereby.

人工流产是一个短时间的小手术,语言交流有时间上的局限性,为了解人工流产者的心理状况,减轻其身心痛苦,帮助消除不良情绪,创造最佳心理状态,使手术顺利进行,非语言交流对人工流产者有着重要功能。1、用关注的目光,微笑的表情稳定人工流产者的情绪,从而减轻她们的紧张、惧怕心理。

It is suggested that mechanisms protecting epidermis of squamata species from UVB damage may involve in (1) Physical defensive mechanism: the death epidermal layer limited UVB transmitting to the viable cells;(2) Biochemical defensive mechanism: up-regulated CAT may protect skin from reactive oxygen species which may induced by UVB. Moreover, the lipid and proteins in the β-, meso- and α-layer may absorb incident UVB and formed damaged products that were limited in the original site;(3) Cellular defensive mechanism: quick initiating of proliferation of the germinal cells and forming of the new epidermis and shedding out the damaged epidermis shortened the damage process and restricted the damage area.

1物理性防御:角质层和中层阻挡绝大部分UVB透过,最大限度地减轻生发层的损伤;(2)生化性防御:通过上调CAT活性以减轻LVB诱导的活性氧对表皮的损伤,同时角质层蛋白质和中层脂类可吸收UVB,且形成的有害产物被局限于原位;(3)细胞性防御:通过迅速启动再生修复过程形成新的表皮,及时蜕去积累了脂类过氧化产物、受损蛋白质和晒斑细胞等的受损表皮,有效防止损伤的持续和蔓延。

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By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候,里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色,卵在发育96h后卵基本全部孵化。

There was a conflict between plebs and patricians in ancient Rome in 494BC.

在公元前494年,罗马发生了一次平民反对贵族的斗争。