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A two-component carbon tetrachloride system and a two-component aqueous system have been treated with the proposed strategy where only 21 calibration samples are needed, and the result showed that the predictive ability was not obviously impaired for the former system while being clearly strengthened for the latter one in comparison with a conventional way that required a calibration set of 100 samples.5 An unlooked-for experimental observation that in near-infrared spectroscopy the second overtone of aniline adsorbed by 13X molecular sieve nearly disappeared led us investigate a fundamental problem: the behavior of NIR when the outside space surrounding a molecule is too small to allow the molecule to vibrate freely.

同时,最小相关样本设计能进一步减少所需的校正样本数,且能提供更多合适变量以建立多元校正模型。这两方面的改进使模型的预测能力得以提高,其预测精度即使在水体系中也有明显的改善。五、近红外漫反射光谱在线非接触监测气-固吸附过程中出现了一个意外现象,即在近红外光谱上,被13X分子筛吸附的苯胺的二级倍频几乎完全消失了。这促使笔者深入探讨了近红外光谱的空间效应(当一分子被一足够小的刚性空间限制时,其振动的受限导致一级倍频和二级倍频强度均减少,并且后者减少的程度比前者更大)。

Execute " with large generation small " hind, can reduce generate electricity coal consumption and ensure moving economy, safe; is ameliorable atmosphere environment, reduce the contaminant; such as discharged soot, SO2 to be able to reduce water resource is used up and; of liquid waste discharge capacity can reduce discharge capacity of grey broken bits and noise.

实行&以大代小&后,可降低发电煤耗和确保运行经济、安全;可改善大气环境,减少排放的烟尘、SO2 等污染物;可减少水资源消耗和废水排放量;可减少灰渣排放量和噪声。

The score of renal calcium oxalate crystallization of 12%,25% medlar soak and apozem was reduced 38.7%, 54.8% and 48.4%, 58.1%(P.01) compared with the ethylene glycol drinking group. Conclusions: LBP can reduce the formation of renal calcium oxalate crystallization. The mechanism is to protect from damage by free radical and reduce the apoptosis of renal tubular epithelial cell by hyperoxaluria.

适量的枸杞多糖可减少饮用诱石剂大鼠的肾草酸钙结石形成,其作用机制是通过抗氧化反应,减少自由基对肾组织的损伤,从而减少高草酸尿对肾小管上皮细胞的凋亡。

"We suggest a regular, simple urethral dilation protocol for patients with recurrent bulbomembranous urethral stricture shorter than 2 cm, because this significantly allays the stricture recurrence rate, possibly eliminates the need for consecutive DVIU, and reduces morbidity," the authors write.

作者认为,对复发bulbomembranous的尿道狭窄小於2 公分的患者,最好有一个常规且简单的尿道扩张方法,因为可以显著减少尿道狭窄的复发率,可能还可以减少DVIU治疗的次数而减少发病率。

"We suggest a regular, simple urethral dilation protocol for patients with recurrent bulbomembranous urethral stricture shorter than 2 cm, because this significantly allays the stricture recurrence rate, possibly eliminates the need for consecutive DVIU, and reduces morbidity," the authors write.

作者认为,对复发bulbomembranous的尿道狭窄小于2 公分的患者,最好有一个常规且简单的尿道扩张方法,因为可以显著减少尿道狭窄的复发率,可能还可以减少DVIU治疗的次数而减少发病率。

Different treatment regimens had been designed according to different classification.②Properly combined chemotherapy protocols reduced therapy intensity and decreased drug toxicities to patients with standard risk ALL.High dose methotrexate,instead of craniospinal radiation,had become effective phylaxis,and decreased the incidence of extramedullary relapse and CNSL (if indispensably,radiation dose was reduced).This measurement reduced radiation chemotherapy long term side effects and improved survival quality.

化疗方案合理组合在保证疗效的同时对ALL后期治疗降低强度,减少药物毒性,同时改进了庇护所预防措施———采用大剂量氨甲蝶呤,大大减少了髓外复发,使相当一部分患儿放弃以往颅脑预防性放疗,即使需要放疗者也降低了剂量,从而减少放化疗远期毒副作用,提高了生存质量。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan (the average body weight was 25~30 kg)were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P<001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P<001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P<001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P<001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系,探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只,平均体重25~30 kg。随机分为3组:正常对照组10只,模型组10只(球囊内膜剥脱加高胆固醇饮食),治疗组10只(球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d)。结果兔髂动脉造影、血管病理图像分析检测结果:①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比,各组之间有显著性差异(P<001)。②免疫组化分析:模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组(P<001);复方丹参滴丸组MMP2、MMP9的表达低于模型组,而TIMP1、TIMP2的表达高于模型组;TIMP1/MMP2、TIMP2/MMP9明显增加,差异有显著性(P<001)。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896,P<001)。结论 MMP和TIMP在再狭窄形成中起重要作用;复方丹参滴丸能够明显抑制血管损伤后的内膜增生,可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生,而减少内膜的增生。

In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia and/or astrocytes and/or by reducing reactive gliosis.

另外,根据本发明的化合物特别通过减少小胶质细胞和/或星形细胞的活化和/或通过减少反应性的神经胶质增生而能够减少影响神经系统的疾病的炎性物质。

The mean conˉcentrationsof the total bile acid in the gallbladders were respectively77.53±11.93,51.81±8.12and53.27±7.04in group DM,CH and DMCH,but it was79.28±18.28in group N.Combined bile acids(both glycocholic acid and taurocholic acid)were apparently lessened and the ratio of cholic acid and chenodeoxycholic acid was rised in group DM,CH and DMCH,the concentrationsof cholesterol were respectively5.31±0.81,5.69±2.20and5.12±1.47,but0.86±0.20,in the group N;those of phospholipd were respectively0.35±0.16,0.52±0.18and1.38±0.34,but0.59±0.28,group N.

胆囊胆汁成分分析中,DM组、CH组和DMCH组总胆汁酸分别为77.53±11.93、51.81±8.12和53.27±7.04,N组为79.28±18.28;与N组比较结合胆汁酸减少,其中甘氨胆汁酸盐与牛磺胆汁酸盐均减少;鹅去氧胆酸减少,胆酸/鹅去氧胆酸比值升高;胆汁胆固醇分别为5.31±0.81、5.69.20和5.12±1.47,N组为0.86±0.20;磷脂分别为0.35±0.16、0.52±0.18和1.38±0.34。

Stones were seen in the gallbladder of12/12cases in either group DM and CH,and11/12in the group DMCH.The mean conˉcentrationsof the total bile acid in the gallbladders were respectively77.53±11.93,51.81±8.12and53.27±7.04in group DM,CH and DMCH,but it was79.28±18.28in group N.Combined bile acids(both glycocholic acid and taurocholic acid)were apparently lessened and the ratio of cholic acid and chenodeoxycholic acid was rised in group DM,CH and DMCH,the concentrationsof cholesterol were respectively5.31±0.81,5.69±2.20and5.12±1.47,but0.86±0.20,in the group N;those of phospholipd were respectively0.35±0.16,0.52±0.18and1.38±0.34,but0.59±0.28,group N.

胆囊胆汁成分分析中,DM组、CH组和DMCH组总胆汁酸分别为77.53±11.93、51.81±8.12和53.27±7.04,N组为79.28±18.28;与N组比较结合胆汁酸减少,其中甘氨胆汁酸盐与牛磺胆汁酸盐均减少;鹅去氧胆酸减少,胆酸/鹅去氧胆酸比值升高;胆汁胆固醇分别为5.31±0.81、5.69.20和5.12±1.47,N组为0.86±0.20;磷脂分别为0.35±0.16、0.52±0.18和1.38±0.34。

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