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The first part consists of three experiments:(1) The rings were incubated in KH, 20, 50 mmol/L 〓 for 1 house, relaxation in response to the EDHF stimuli A23187 in 30nmol/L U46619-induced preconrtaction in the presence of 7 μ mol/L indomethacin, a cyclooxygenase inhibitor, 300μmol/L LNNA, a nitric oxide biosyhnthesis inhibitor, and 1mmol/L tetraethylammonium , a 〓 blocker, or 3 μmol/L glibenclamide , a 〓 blocker, was compared with the control;(2) After the arteries were incubated in KH, UW solution or HTK solution at 4℃ for 4 hours, endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μmol/L indomethacir and 300μmol/L LNNA;(3) After incubation with KH, UW solution and STH (either at 37℃ in oxygenated organ chamber or at 4℃ in a refrigerator for 4 hours), endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μ mol/L indomethacin and 300 μmol/L LNNA.

第一部分研究结果:(1)单纯浸泡于KH的冠状动脉A23187能引发66.67%的血管舒张反应,经TEA及20mmol/L、50mmol/L钾离子作用后,血管舒张反应程度显著降低,但经GBM作用后改变不明显;(2)与保存于KH的冠状动脉相比,A23187引发的血管舒张反应程度,保存于UW液的明显下降,保存于HTK液的无明显变化;(3)在37℃条件下,血管环浸泡于STH出现缓慢轻微的舒张反应,浸泡于UW液初期出现短暂收缩反应,但此后主要以舒张为主:在37℃条件下,血管经UW液保存后,U46619引发的收缩反应程度降低;不论在37℃或4℃条件下,A23187引发的血管舒张反应,经UW液保存后明显下降,但用STH保存后变化不明显。

CAC was identified in 2003 as a cardiovascular disease risk factor and an independent predictor of mortality. Investigators have known since at least 1996 that CAC is from 2 to 5 times more extensive in people on hemodialysis than in people with coronary artery disease but not kidney disease, said Dr. Asci, a nephrologist at the Ege University School of Medicine in Izmir, Turkey. Subsequent studies have shown an association between CAC and left ventricular hypertrophy and coronary abnormalities, including atherosclerosis, stiffness, and perfusion problems.

土耳其Lzmir Ege大学医学院肾脏科医师Asci医师表示,CAC在2003年即被确认为是心脏血管疾病的危险因子,同时也是独立的死亡率预测因子;研究者早在1996年就知道,相较於无肾脏疾病之冠状动脉疾病患者,透析病患CAC的情形普遍2~5倍;接下来的研究结果显示,CAC与左心室肥大与冠状动脉血管异常,包括粥状动脉硬化、血管硬化、与灌流异常是有关连的。

Objective: To determine if an aggressive approach to coronary revascularisation with oversized balloons is counterproductive, we studied the effect of increasing balloon-to-artery ratio on neointimal hyperplasia following primary stent placement using a non-atherosclerotic porcine coronary overstretch model.

目的:为了确定在冠状动脉重建术中使用过大的球囊这种过于积极的措施是不是有反作用,我们研究了首次支架置入术后增加的球囊比动脉比值对新生内膜增生的影响,模型是没有动脉粥样硬化的猪的过度牵张的冠状动脉。

(1)The levels of MCP-1 and VEGF'levels was significant increased in CHD patients,Compared with controls, It was implicated that they might take part in the actions of informing atherosderotic plaques;(2)The serum level of MCP-1 and VEGF were elavated step by stey among the group of controls、SAP、UAP、AMI, It was thought they might develop the matter on the stability of atherosderotic plaques;(3)The serum level of MCP-1 and VEGF were positive correlated with 7-TIMI risk score, It prompt that MCP-1 and VEGF was the reactiveness markers of coronary artery process ,and developed the risk to major acute cardiac events.

(1)血清MCP-1、VEGF水平在冠心病患者中显著升高,提示MCP-1、VEGF可能在促进冠状动脉粥样硬化斑块形成的过程中起重要作用;(2)血清MCP-1、VEGF水平在对照组、各冠心病亚组(SAP、UAP、AMI组)之间逐级升高,提示MCP-1、VEGF可能增加了冠状动脉粥样硬化斑块的不稳定性;(3)联合检测MCP-1、VEGF的灵敏度\特异度上升,证明临床上联合检测二者血清指标意义大;并且血清MCP-1、VEGF水平和7-TIMI积分呈正相关性,7-TIMI积分高的患者血清MCP-1、VEGF水平也高,说明它们能作为冠脉病变的活动性标志物,可能成为评价主要心血管恶性事件的危险性的相关指标。

The optimal reconstruction windows of patients with stable HR(≤75 bpm and≥91 bpm) were concentrated in 71%,ranged from 65%-80%, and in 41%,ranged from 32%—50%,respectively.The prospectively ECG-gated DSCT coronary angiography can be used in patients with stable HR(≤75 bpm and≥91 bpm) in abstract.②To explore the clinical application of prospectively ECG-gated transverse DSCT coronary angiography.Methods Two hundreds patients[Body mass index:23-25 kg/m~2,122 patients(average HR≤75 bpm),78 patients(average HR≥91 bpm)]with suspected or known coronary artery disease underwent prospectively ECG-gated transverse DSCT coronary angiography,among them,30 patients underwent selectively coronary angiography,grouping them into 2 groups according to the average HR of scanning.Group A(17 cases,HR≤75 bpm),group B(13 cases, HR≥91 bpm),the DSCTA results were compared with SCAG.Then,calculate the accuracy of patients in each group and evaluate the agreement of accuracy between DSCTCA and SCAG by Kappa statistics.

方法回顾性分析200例行适应性前瞻性心电门控双源CT冠状动脉血管成像的患者(排除扫描过程中,屏气配合差,出现心律不齐的患者及行支架置入或搭桥术后复查的患者),包括屏气时平均HR≤75 bpm患者122例,HR≥91 bpm患者78例;其中30例同期行选择性冠状动脉血管造影,按屏气时HR将其分为2组,A组17例:HR≤75 bpm,B组13例:HR≥91 bpm,分别与金标准SCAG对照,计算2组患者的阳性诊断准确率,应用SPSS 13.0统计学软件,利用Kappa检验比较每组患者的2种诊断方法诊断结果的一致性,利用两样本率x~2检验,比较2个心率组间的诊断准确率有无明显统计学差异,并计算此30例患者的平均有效辐射剂量。

Coronary artery vasospasm can cause a transient, abrupt, marked decrease in the diameter of an epicardial coronary artery.

冠状动脉血管痉挛能造成一个暂时的,突然的,显著的心外冠状动脉内径的减少。

Coronary artery vasospasm can cause a transient, abrupt, marked decrease in the diameter of an epicardial coronary artery.

摘要冠状动脉血管痉挛能造成一个暂时的,突然的,显着的心外冠状动脉内径的减少。

A coronary microthromhoembolism model was successfully established by injecting sodium laurate into the coronary arteries. Coronary micro-thrombogenesis may promote the apoptosis of cardiomyocytes, and is one of the reason for heart function decrease. Telmisartan can efficiently suppress ventricles reconstruction, improve heart function, and inhibit the apoptosis of myocardial cells after microthrombogenesis in coronary artery.

冠状动脉内注射月桂酸钠能够成功建立冠状动脉微血栓的模型;冠脉内微血栓增加心肌细胞的凋亡,是导致心功能下降的原因之一;替米沙坦能有效地抑制心脏重塑,改善心功能,并能抑制冠脉微血栓后心肌细胞的凋亡。

The cyclic variation of integrated backscatter and echo intensity of three different myocardial regions perfused by left anterior descending coronary artery, left circumflex coronary artery and right coronary artery (on the frozen frame of parasternal short-axis image,those position were approximately at the 12, 4 and 8 o'clock direction to the center of the left ventricle, respectively) were measured with HP-5500 ultrasonic system and DFY ultrasonographic quantitative analysis system.

在35例急性心肌梗死患者发病2周内,用HP-5500型超声诊断仪和DFY型超声图像定量分析诊断仪,在胸骨旁左室乳头肌短轴切面,分别测量冠状动脉左前降支、左回旋支和右冠状动脉支配区域心肌组织(分别相当于左室乳头肌短轴切面上12、4、8点的位置)的IB和EI心动周期变化幅度值,以CVIB和CVEI值≤同一切面三个不同部位中最高值的1/2作为诊断心肌梗死的标准,部分病例与冠脉造影结果对比。

Other studies have found that the amount of coronary calcium correlates with the amount of atherosclerosis or hardening of the coronary arteries and is related to the likelihood of developing heart disease in the future.

其他一些研究也发现,数额冠状动脉钙化程度与数额的动脉粥样硬化或硬化的冠状动脉狭窄,并涉及到的可能性发展中国家心脏病的未来。

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Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

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