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Objective To investigate whether tyrosine protein kinases Src and Fyn were involved in the phosphorylation of NR2A induced by cerebral ischemia followed by reperfusion. Methods Transient (15 min) brain ischemia was induced by the four-vessel occlusion in Sprague-Dawley rats. The antisense oligodeoxynucleotides of Src and Fyn were used to suppress the expression of Src and Fyn by intracerebroventricular infusion once a day for 3 days before ischemia.

近年来,最受人们关注的缺血性脑损伤机制是兴奋性氨基酸(excitatory amino acid, EAA)的神经毒性作用及神经元内钙超载触发的级联反应[1],其中NMDA受体的NR2亚基在缺血性脑损伤中起着非常重要的作用,在缺血/再灌注(ischemia/ reperfusion,I/R)过程中其蛋白表达、磷酸化水平均有改变。

Wellington, driven into a corner at the forest of Soignes and destroyed--that was the definitive conquest of England by France; it was Crecy, Poitiers, Malplaquet, and Ramillies avenged.

皇上半立在他的踏镫上。眼睛里闪起了胜利的电光。把威灵顿压缩到索瓦宁森林,再加以歼灭,英格兰便永远被法兰西压倒了,克雷西①、普瓦蒂埃②、马尔普拉凯③和拉米伊④的仇也都报了。

Parents watched helplessly as the Pied Piper,playing merrily,led all of Hamelin's youngsters out of town,after which they were never seen again.

父母们无奈地望着彩衣魔笛手吹起了欢快的笛声,带着所有的孩子走出了哈默尔恩镇。人们从此再没见到孩子们的踪影。

Stories of change poured in from all over India, from Nagaland in the east, to Jhunjhunu in the west, from Sikkim in the north, to Krishnagiri in the south. Children were designing solutions for a diverse range of problems.

于是关于改变的故事,从印度各地如雪片般飞来,东起 Nagaland 西至 JhunJhunu 北及 Sikkim,南通Krishnagiri 孩子们自行设计了各式各样问题的解决方案,从消除孤独感觉,修补路面不平,再到酗酒。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。