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This study examined whether iral ectors could be used to delier the BDNF gene in a less damaging fashion and whether this could promote a regeneratie response in injured rubrospinal neurons.

本研究检测了病毒载体是否可以用来在比较小的损伤模型上促进BDNF基因的释放,以及它是否可以激发受损红核脊髓神经元的再生反应。

Following axotomy in the cervical spinal cord, rubrospinal neurons undergo severe atrophy and fail to up-regulate important genes for regeneration.

背景概述:在颈椎脊索轴性切开后,往往会出现红核脊髓神经元的严重萎缩,合并决定再生的重要基因上调不能。

Objective. To determine if viral vectors carrying the gene for brain-derived neurotrophic factor could be used to promote an axonal regenerative response in rubrospinal neurons after an acute cervical spinal cord injury.

目标:本研究在于确定病毒带菌体存在着一种大脑源性神经营养因子的基因,这种基因可以在急性颈髓脊索损伤所致病例中引发红核脊索神经元的轴性再生反应。

Summary of Background Data. Following axotomy in the cerical spinal cord, rubrospinal neurons undergo seere atrophy and fail to up-regulate important genes for regeneration.

背景概述:在颈椎脊索轴性切开后,往往会出现红核脊髓神经元的严重萎缩,合并决定再生的重要基因上调不能。

Objectie. To determine if iral ectors carrying the gene for brain-deried neurotrophic factor could be used to promote an axonal regeneratie response in rubrospinal neurons after an acute cerical spinal cord injury.

目标:本研究在于确定病毒带菌体存在着一种大脑源性神经营养因子的基因,这种基因可以在急性颈髓脊索损伤所致病例中引发红核脊索神经元的轴性再生反应。

Pathological observations showed that the bone marrow and spleen of non-treated IMAA mice demonstrated typical aplastic anemia pattern, including bone marrow failure, marked splenatrophy, but the bone marrow and lymphoid tissues in the IMAA mice of irradiation-treated group were recovered to normal at day 28 after treatment.

结果表明:①IMAA组小鼠活存率为12.5%,平均存活时间为27.4 13.4天,照射治疗组活存率为100%,平均存活时间60天以上,单纯照射组无死亡;②外周血白细胞数:IMAA组呈进行性下降,直至死亡,照射治疗组第10天与免疫再障组相似,以后开始缓慢回升,基本上达到治疗前水平;③红细胞比容:未治疗IMAA组于14天后呈进行性降低,至第35天比实验前减低2/3,照射治疗组与单纯照射组一样,第14天有轻度减低随后升高,至35天接近正常;④骨髓有核细胞数:IMAA组呈进行性减低,无恢复趋势,照射治疗组于一过性减低后迅速增加,第28天达到正常水平;⑤骨髓和淋巴组织病理形态观察:IMAA组小鼠呈典型再生障碍性贫血病理改变,骨髓造血衰竭,脾脏明显萎缩,而照射治疗组于第28天骨髓和脾淋巴脏组织基本上恢复正常。

The transplanted cells can be integrated into the vascular walls of the capillaries and arterioles and differentiate into cardiomyocytes.

移植的单个核细胞可以在梗死区域中存活,增殖,分化和迁移,增加梗死区域的微血管数量,再生、再造心肌。

It is understood that the original Takara has produced works of nuclear power and nuclear-related products more than 40 kinds of Taiwan, more than 2000 pieces, including the renewable power plant heat exchangers, electrical cross-pieces of the reactor pressure vessel support, accelerator steel shell, the shear components machine and so on, is the only domestic supplier of nuclear spent fuel records and personnel separated from the gate frame manufacturers.

据了解,大连宝原已生产出的核电与核工程相关的产品40多种2000多台件,包括核电站再生热交换器、电气贯穿件、反应堆压力容器支撑、加速器钢外壳、元件剪切机等,是国内唯一有供货记录的核乏燃料隔架和人员闸门的制造厂商。

Radionuclide imaging: In graft side, there were obvious uptakes of the ^99mTc-MDP and revascularization; In control side, there was no process of bone regeneration and bone metabolism.

放射性核素显像:实验侧有较明显的核浓聚和再生血管化现象,对照侧无骨重建,故无骨代谢变化。

Objective: To investigate the role of p75NTR in the regeneration of facial nerve nuclei during nerve crush injury.

目的:探讨P75NTR在面神经损伤后面神经核运动神经元再生中的作用。

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