内酰胺

Lactam was gained by the Staudinger reaction of imine and olefineketone in the presence of N-heterocyclic carbene catalyst.

以N-杂环卡宾催化剂1催化亚胺与烯酮之间的Staudinger反应，得到相应的β-内酰胺。

The loss or diminishment of OprD2 was the main reason for the imipenem resistance of P.aeruginosa in our hospital, but its effect on meropenem resistance deserved further study.

在对亚胺培南耐药的菌株中，合并有其他β-内酰胺类抗生素耐药的菌株达到62.34%(48/77)。32株Pa外膜蛋白电泳结果显示OprD2相对含量在耐药组为0～3.5%(其中有一株为8.70%)，敏感组为6.20%～10.20%。

No reactions were observed for reactions of benzodiazepines with ketene atroom temperature; but the reaction of benzothiazepines with monochloroketene gave[2+2] cycloadducts .

发现在室温下苯甲酰基苯并二氮杂卓与烯酮没有反应，而苯并硫氮杂卓与一氯烯酮形成了正常的β-内酰胺环产物。

It should be noted that the reaction with alkylimines failed to give the,β-lactam under current standard reaction conditions.

值得注意的是，在相同条件下，烷基亚胺参与的该反应都没能得到相应的β-内酰胺。

Lactam ring opening.That is to say,the inhibition mechanisms ofβ-lactamase are not yet fully understood.

它们大多只是集中在抑制剂的酰化反应上，而β-内酰胺开环以后的反应，理论研究少之又少。

DAC, similar to CPC in structure, contains theβ-lactam ring.

去乙酰头孢菌素C的结构与头孢菌素C类似，含有β-内酰胺环。

They were identified as 3-imino-N-(α-imidoethylamino)butyrolactam and neononane tetracid, respectively. The antitumoral activity on liver tumor cells SMMC-7721 was determined in vitro.

根据化合物的理化、谱学性质及X-射线晶体衍射分析结果，确定2个羧酸衍生物类化合物为3-亚胺基-N-丁内酰胺和新壬四酸。

Results totally 287 strains were isolated from the 256 positive samples , and the gram-negative bacilli were 225(78.4%,), the gram-positive coccus were 41(14.3%), snd the monilia were 21(7.3%).the distributions of clinical bacteria were respiratory tract(63.4%),urinaryract(7.0%),secretion(includingwound .3%),blood(5.9%),stool(5.2%), pucture fluid(4.9%), and other sites(7.3%). of all isolating bacterium,from the first to the fifth were ps.aeruginosa(19.5%),k.pneumoniae(16.7%), e.coli(14.3%), a.baumannii(11.8%) and psemal (10.1%).resistant rates of methecillin-resistant s.aureus,methecillin-resistant coagulase-negative staphylococci and vancomycin-resistantwere 88.2%、70.0% and 11.1% respectively;the incidence of e.coli and k.penumoniae produce extended speutrum beta-lactamase were 68.6%和65.2%, 44.6% of ps.aeruginosa isolates were resistant to imipenem; the highest examining rate of 21 kinds of monilia was candida albicans (66.7％),resistant rate of candida albicans to fluconazole and amphotricin b was 51.3％ and 1.3%.

结果 在254份检出细菌阳性标本中共培养出287株细菌，其中革兰阴性杆菌225株（78.4％），革兰阳性球菌41株（14.3%），念珠菌21株（7.3%），检出菌来自呼吸道标本占63.4%，其他标本各占5%左右；细菌检出占构成比前三位的依次为铜绿假单胞菌19.5%、肺炎克雷伯菌16.7%、大肠埃希菌14.3%；耐甲氧西林金黄色葡萄球菌、耐甲氧西林凝固酶阴性葡萄球菌和耐万古霉素的肠球菌的发生率分别为88.2%、70.0%和11.1%；大肠埃希菌和肺炎克雷伯菌的超广谱β-内酰胺酶的检出率分别为68.6%和65.2%，铜绿假单胞菌对亚胺培南的耐药率为40.2%；白色念珠菌对氟康唑的耐药率为81.3％，对两性霉素的耐药率为3.2%。

In the last part we first synthesized the propargylic amines though several methods and then developed a new methodology for the synthesis of -α-chloroalkylidene-β-lactams via the catalysis of PdCl〓 with CuCl〓 and BQ with moderate to good yields and good generality.

论文的第三部分工作是我们首先通过几种方法合成了炔丙基胺化合物，接着对PdCl〓催化的炔丙基胺的羰基插入环化反应进行了研究，以中等收率得到-α-氯代亚烷基-β-内酰胺化合物，反应的普适性良好。

The chromosomally located cephalosporinase and carbapenem-hydrolyzing beta-lactamase NmcA were inducible by cefoxitin and meropenem in E. cloacae NOR-1, and both were stably overproduced in the ceftazidime-resistant mutant.

在E阴沟杆菌NOR-1中，位于头孢菌素酶和氨基甲酰水解的β-内酰胺酶NmcA中的染色体可以被头孢西丁和美罗培南诱发，而且两者在头孢三嗪噻肟抗体突变体中都是稳定的大量产生的。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。