内酯化

Mission:"equality and mutual benefit, reputation first, unity and cooperation and friendship between the long-term" supply products: ethylenediamine; diethylamide; triethylamine; Diethylenetriamine; three ethylene diamine; three ethylene amines 40; 40 Five ethylene amines; five ethylene amines 6; caprolactam; DMF; allyl amine; N, N dimethylaniline; propylamine; are butylamine; are TOA; 3 Poly Cyanamide; 1,2 c diamine; ethanolamine; diethanolamine, triethanolamine; potassium iodide, potassium hydroxide, potassium permanganate, toluene, xylene, toluene of chlorine ; Acetone, butanone; acetylacetone; ethyl acetate, butyl acetate; Y-butyrolactone; DMC; acetyl of methyl acetate; Sanfu acetyl acid; Sanfu acetyl B Ethyl; methanol, ethanol, isopropanol; propylene glycol; glycerol; propargyl alcohol; 1.3 propylene glycol; xylitol; acetic acid; have acid; mercaptoacetic acid; vary Bitterness; adipic acid; trifluoroacetic acid; oxalic acid, the amino acid; o-amygdalin acid; DL-Acid; anhydrous piperazine; six non-piperazine, furfural, castor oil, ethylene Aldehyde; glutaraldehyde, multi-POM; isopropyl ether; anisole; tetrahydropyrrole; pure pyridine; 1.2 dichloroethane; methylene chloride, chloroform, carbon tetrachloride; hydrazine hydrate; Nonylphenol;-m-cresol; Se phenol; phenol; the tert-butyl phenol; Titanium Dioxide; iron; full Tangfen; Bisphenol A; azo two different nitrile; sodium azide; sodium carbonate ; Sodium chloride; iron oxide; cuprous chloride; thionyl chloride; D4; sodium bicarbonate; ammonia, potassium chloride; anhydrous sodium sulphite; ammonium persulfate; glycol Dingmi; B Glycol ether; calcium chloride; cyclohexanone; cyclohexane, methyl tertiary butyl ether, potassium carbonate, ferric chloride, potassium nitrate; Linsuansanna; zinc oxide; sodium nitrite; antimony oxide; Tartrate; OP-10; TX-10; tablets base; AES; sodium benzoate, sodium citrate; partial sodium silicate, sodium perborate, a sodium carbonate, sodium benzene; Asia sodium chlorate; Wuluo Care products; urea; hydrochloric acid, sulfuric acid, lactic acid; amino acid, hydrogen peroxide, ammonium bicarbonate

公司宗旨："平等互利，信誉至上，团结合作，友谊长久"乙二胺；二乙胺；三乙胺；二乙烯三胺；三乙烯二胺；三乙烯四胺；四乙烯五胺；五乙烯六胺；己内酰胺；二甲基甲酰胺；烯丙基胺；N，N二甲基苯胺；正丙胺；正丁胺；正辛胺；三聚氰胺；1，2丙二胺；一乙醇胺；二乙醇胺；三乙醇胺；碘化钾；氢氧化钾；高锰酸钾；甲苯；二甲苯；对氯甲苯；丙酮；丁酮；乙酰丙酮；醋酸乙酯；醋酸丁酯；Y-丁内酯；碳酸二甲酯；乙酰乙酸甲酯；三伏乙酰乙酸；三伏乙酰乙酸乙酯；甲醇；无水乙醇；异丙醇；丙二醇；丙三醇；丙炔醇；1.3丙二醇；木糖醇；冰醋酸；己醛酸；巯基乙酸；异辛酸；己二酸；三氟乙酸；乙二酸；对氨基苯乙酸；邻氯苦杏仁酸；DL-扁桃酸；无水哌嗪；六无哌嗪；糠醛；蓖麻油；乙二醛；戊二醛；多聚甲醛；异丙醚；苯甲醚；四氢吡咯；纯吡啶；1.2二氯乙烷；二氯甲烷；三氯甲烷；四氯化碳；水合肼；壬基酚；纯间甲酚；硒酚；苯酚；对叔丁基苯酚；钛白粉；铁粉；全糖粉；双酚A；偶氮二异丁腈；叠氮化钠；碳酸钠；氯化钠；三氧化二铁；氯化亚铜；氯化亚砜；D4；碳酸氢钠；氨水；氯化钾；无水亚硫酸钠；过硫酸铵；乙二醇丁醚；乙二醇乙醚；氯化钙；环己酮；环己烷；甲基叔丁基醚；碳酸钾；三氯化铁；硝酸钾；磷酸三钠；氧化锌；亚硝酸钠；氧化锑；酒石酸；OP-10；TX-10；粒碱；AES；苯甲酸钠；柠檬酸钠；偏硅酸钠；过硼酸钠；过碳酸钠；苯磺酸钠；亚氯酸钠；乌洛托品；尿素；盐酸；硫酸；乳酸；氨基磺酸；双氧水；碳酸氢铵

Water,propylene glycol,butylene glycol,glyceryl polymethacrylate,peg-7 glyceryl cocoate,biosaccharide gum-1,phenoxyethanol,hydroxyethylcellulose,ppg-26-buteth-26,chondrus crispus,peg-40 hydrogenated castor oil,sodium hydroxide,methylparaben,benzophenone-4,disodium edta,citrus aurantium dulcisoil,sorbic acid,butylparaben,ruscus aculeatus root extract,glycyrrhiza glabraroot extract,aesculus hippocastanumseed extract,pentadecalactone,iris germanica root extract,rentinyl palmitate,tocopheryl acetate,sodium hyaluronate,citrus aurantium amaraoil,sorbitol,propylparaben,ethylparaben,limonene,linalool,yellow 5,red 4,red 33

水，丙二醇，丁二醇，甘油聚甲基丙烯酸酯，PEG-7 椰子油酸单甘酯，多醣物质，苯氧乙醇，羟乙基纤维素，PPG-26-丁醇聚醚-26，卡拉胶，PEG-40氢化蓖麻油，氢氧化钠，羟苯甲酯，二苯酮-4，乙酸乙二胺二钠，甜橙油，山梨酸，羟苯丁酯，假叶树根萃取，甘草根萃取，欧洲七叶树籽萃取，环十五内酯，鸢尾花根萃取，维他命A酯，醋酸盐维他命E ，透明质酸钠，苦橙油，山梨醇，羟苯丙酯，羟苯乙酯，柠檬精油，芳樟醇，黄5，红4，红33水：几乎所有护肤品成分第一位都是水。丁二醇：保湿剂及溶剂，质地温和

Water,butylene glycol,biosaccharide gum-1,ppg-26-buteth-26,panthenol,peg-40 hydrogenated caster oil,hydroxyethylcellulose,imidazolidinyl urea,saccharide isomerate,benzophenone-4,phenoxyethanol,triethanolamine,citrus aurantium dulcisoil,pentadecalactone,methylparaben,sodium hyaluronate,citric acid,butylparaben,ethylparaben,citrus aurantium amaraoil,propylparaben,methylchloroisothiazolinone,methylisothiazolinone,red 4,yellow 5,red 33,limonene,linalool

水，丁二醇，多醣物质，PPG-26-丁醇聚醚-26，维生素B5，PEG-40氢化蓖麻油，羟乙基纤维素，尿素醛，天然异构寡糖，二苯甲酮- 4，苯氧乙醇，三乙醇胺，甜橙油，环十五内酯，羟苯甲酯，透明质酸钠，柠檬酸，羟苯丁酯，羟苯乙酯，苦橙油，羟苯丙酯，甲基氯异塞唑晽酮，甲基异噻唑啉酮，红4，黄5，红33，柠檬精油，芳樟醇

Water,butylene glycol,glycerin,glyceryl polymethacrylate,triethanolamine,carbomer,ppg-26-bueth-26,chondrus crispus,peg-40 hydrogenated castor oil,phenoxyethanol,imidazolidinyl urea,propylene glycol,benzophenone-4,retinyl palmitate,citrus aurantiudulcisoil,phospholipids,methylparaben,tocopheryl acetate,c12-23 alkyl lactate,disodium EDTA,centella asiatica extract,iris germanica root extract,pentadecalactone,aloe barbadensis leaf juice,mimosa tenuiflora bark extract,sodium hyaluronate,menthol,biosaccharide gum-1,citrus aurantium amara oil,propylparaben,methylchloroisothiazolinone,sodium benzoate,potassium sorbate,citric acid,calcium sorbate,methylisothiazolinone,butylparaben,ethylparaben,yellow 5(CI 19140),limonene,linalool

水，丁二醇，甘油，甘油聚甲基丙烯酸酯，三乙醇胺，卡波姆，PPG-26-丁醇聚醚-26，鹿角菜胶，PEG-40 氢化蓖麻油，苯氧乙醇，尿素醛，丙二醇，二苯酮-4，维他命A酯，甜橙油，磷脂质，羟苯甲酯，醋酸盐维他命E，C12-13 烷醇乳酸酯，乙二胺四乙基二钠，雷公根萃取，鸢尾花根萃取，环十五内酯，吉拉索芦荟叶汁，含羞草萃取，透明质酸钠，薄荷脑，多醣物质，苦橙油，羟苯丙酯，甲基氯异塞唑晽酮，苯甲酸钠，山梨酸钾，柠檬酸，山梨酸钙，甲基异噻唑啉酮，羟苯丁酯，羟苯乙酯，柠檬黄，柠檬精油，沈香醇水：几乎所有护肤品成分第一位都是水。丁二醇：保湿剂及溶剂，质地温和

Water,propylene glycol,butylene glycol,glyceryl polymethacrylate,ascorbic acid,peg-7 glyceryl cocoate,biosaccharide gum-1,peg-40 hydrogenated castor oil,ppg-26-buteth-26,phenoxyethanol,hydroxyethylcellulose,xanthan gum,methylparaben,pentadecalactone,citrus aurantium dulcisoil,disodium edta,sorbic acid,tocopheryl acetate,butylparaben,retinyl palmitate,iris germanica root extract,sodium hyaluronate,ethylparaben,propylparaben,citrus aurantium amara oil,limonene,linalool

水，丙二醇，丁二醇，甘油聚甲基丙烯酸酯，维生素C衍生物，PEG-7 椰子油酸单甘酯，多醣物质，PEG-40氢化蓖麻油，PPG-26-丁醇聚醚-26，苯氧乙醇，羟乙基纤维素，山羊胶，羟苯甲酯，环十五内酯，甜橙油，乙酸乙二胺二钠，山梨酸，醋酸盐维他命E，羟苯丁酯，维他命A酯，鸢尾花根萃取，透明质酸钠，羟苯乙酯，羟苯丙酯，苦橙油，柠檬精油，芳樟醇

Other methyl nucleophiles includingMeMgBr, MeCeCl2, MeTiCl3, Me3Al, Me3ZnMgCl, MeMnClwere tried, but in all these cases no detectable amount of exo-C8-methylated product was obtained. Although protecting C3-carbonyl as 1,3-dioxolanes could be achieved, the serious enolization of C8-carbonyl was still problematic. Converting C9-furan ring to α,β-butenolide did depress the enolization, but desired C8-methylation was completely replaced by migration of the double bond of the butenolide.

在本论文的早期阶段，主要着眼于解决二环[3.2.1]-C8-羰基加成甲基所遇到的C9-呋喃环差向异构化和C3与C8两个羰基之间化学选择性的问题：通过引入不同金属降低甲基试剂的碱性并没有取得甲基化的成功；通过不同的方法将C3-羰基掩蔽，但是C8-羰基的烯醇化依然无法抑制；虽然通过将呋喃环转化为α，β-不饱和-γ-丁内酯可以抑制烯醇化，但内酯环上的双键迁移又成了新的竞争反应。

Then the cyclocarbonylation of propargylic alcohols under the catalysis of Pd 〓 with CuBr〓 and BQ was studied. Due to the high activity the yields of -α-bromoalkylidene-β-lactones were lower than that of -α-chloroalkylidene-β-lactones while the coupling reaction of -α-bromoalkylidene-β-1actones (i. e. Sonogashira and Suzuki coupling reaction) was quite smooth to afford the products in high yields.

接着我们研究了炔丙醇在Pd〓-CuBr〓-BQ催化体系下的羰基插入环化反应，由于-α-溴代亚烷基-β-内酯环化合物的活性高于-α-氯代亚烷基-β-内酯环化合物，导致反应收率偏低，而同样基于此原因，-α-溴代亚烷基-β-内酯环化合物的偶联反应进行得很顺利，而且收率很高。

The p-tert-butyl calix arene (n=4,6,8) were synthesized by p-tert-butyl phenol, formaldehyde aqueous solution as raw materials. Six kinds of calixarene oligomeric surfactants were prepared by etherification of the calix arene with 1,3-propane sultone and 1,4-butane sultone.

以对叔丁基苯酚、甲醛为主要原料合成杯芳烃母体对叔丁基杯芳烃(n=4，6，8)；以1，3-丙烷磺内酯、1，4-丁烷磺内酯为醚化试剂，经Williamson醚化反应，合成出6种杯芳烃基低聚表面活性剂。

Starting from the hydroxylamine (dimethyl amino ethanol, triethanolamine) and 1, 3-propane sultone, a series of hydroxyl and sulfonyl dual-functionalized zwitterionic salts were synthesized. Then dual-functionalized ionic liquids containing both hydroxyl and sulfonyl functional groups were produced successfully by zwitterionic salts and three kinds of strong acids (p-toluene sulfonic acid, trifluoromethanesulfonic acid, methanesulfonic acid) respectively. The structure of zwitterionic salts and dual-functional ionic liquids were confirmed by the 1H NMR and IR.

以羟基有机胺(N，N-二甲基乙醇胺，三乙醇胺)为原料与1，3-磺酸内酯反应合成了一系列含有羟基和磺酸基双官能团的内盐，并将所得到的内盐分别与三种强酸(对甲苯磺酸，三氟磺酸，甲磺酸)反应，成功地合成了双功能化室温离子液体，并通过红外光谱、核磁氢谱测定，证实了内盐和双功能化离子液体的结构。

The experiment is optimized by single factor method, and the preferable condition is obtained. The yield of ketopantolactone is 71.8%, and the conversion of ketopantolactone is 99.0%. The DL-pantolactone is resoluted with carbamidine, which is a simple method.

文中通过单因素优化实验，找到了较佳的反应条件，酮基泛内酯的收率为71.8％，催化氢化酮基泛内酯的转化率为99％，DL-泛内酯采用胍作为拆分剂，简单实用。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！