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However, excessive or aberrant ER stress results in cell injury or death.

过度的内质网应激将导致细胞损害和死亡。

These data indicate that GLAST in supporting cells is responsible for transmitter uptake at IHC afferent synapses.

这些试验数据表明,GLAST在支持细胞负责内毛细胞传入突触中摄取递质的功能。

Results Pulmonary carcinosarcoma and blastoma both were found to be rare malignant tumors, and both epithelial and mesenchymal elements can be seen under the microscopy with different characteristic features.

结果 肺癌肉瘤及肺母细胞瘤均为肺内罕见的恶性肿瘤,镜下均可见上皮及间质两种成分,但又有其不同之处,手术前很难确诊。

Forty-five (78%) of the hemangiomas showed homogenous centripetal filling within 180 seconds.

45例(78%)肝血管瘤在180秒内表现为均质的向心性填充。

To study the expression of endoplasmic reticulum molecular chaperon in gastric mucosa infected with Helicobacter pylori.

目的探讨内质网分子伴侣家族成员Grp94、Grp78和PDI在幽门螺杆菌感染者胃黏膜组织中的表达及意义。

The former, intracranially complements patients some factors, most frequently with TH gene to compensate scanty of intrastriatal DA and improve the symptoms of the patients, while have little resistance to the progressive degeneration of dopaminergic neurons; The latter provide variety of neurotrophic factors, most specific being the glial cell-line derived neurotrophic factor , to protect the residual DA neurons in the nigrostriatal system from further pathogenic injuries, while have little benefit to those DA neurons with irreversible damage, and them cannot offset the already-existing symptoms.

前者是给宿主脑内补充某些因子,主要是DA合成过程中的限速酶TH基因,以补充纹状体内DA含量的不足,减轻患者的症状,但对DA能神经元的进行性退变没有治疗效果;后者则是提供各种神经营养因子其中最具特异性的为GDNF,以保护黑质一纹状体系统内剩余的DA能经元免受病因的继续损害但对已发生不可逆性损害的DA能神经元并无拯救作用,无法消除已出现的症状。

ER is well characterized as a mobilizable calcium store that sequesters excess cytosolic calcium and a reservoir for calcium signaling to maintain intracellular Ca2+ homeostasis.

2钙离子的检测 1、细胞内质网是[Ca~(2+)]_i的主要储存场所,以及[Ca~(2+)]_i在细胞凋亡的信号转导通路中所具有的重要作用,本实验研究了SfaMNPV诱导SL-1细胞凋亡过程中细胞内[Ca~(2+)]_i的变化以及[Ca~(2+)]_i可能在凋亡信号转导通路中的意义。

The serum levels of TChE and SOD and CAT in hippocampus of mice in Cold group was also significantly higher than those in the Control group and Warm group(P 0.05或P 0.01),while the serum level of MDA in the Control group and Warm group were higher than that in the Cold group(P 0.05或P 0.01). Conclusion:(1)Long proper winter swimming could improve learning and memory abilities of mice.(2) Winter swimming could improve the ability of learning and memory by coordinate the content of acetylcholinesterase (3) This effect may be related to the decreased activity of TChE and the increased activity of anti-oxidatio.

1长期适量的冬泳运动可以促进小鼠学习记忆能力。2冬泳运动可以通过增加小鼠脑内海马组织中ACh的含量而影响TChE的活力。3冬泳运动促进学习记忆的机制可能是:3.1冬泳运动通过冷应激引起的神经内分泌系统的反应,来改变中枢神经系统的功能,使小鼠脑内乙酰胆碱的代谢增强、含量增加,从而促进学习记忆能力。3.2冬泳运动通过增强机体清除自由基的能力,来减轻脂质过氧化的程度,对小鼠的脑损伤起到保护作用,从而促进学习记忆能力。

Results: in contrast with model group, SSM can (1) increase the survival rate of ARF in rats, cut down Scr and BUN at 24hr, improve renal function, slightly surpass Vp in its therapeutic effect;(2) mitigate the extent of renal pathologicchanges, decrease the numbers of renal tubule necroses and casts;(3) protect renal ultrastructure such as microvilli, mitochondria, endoplasmic reticulum of TEC, podocytic process of glomerulus epithelial cell,endothelial cell etc, better than Vp;(4) enhance SOD activity, lower MDA contents in renal cortex;(5) enhance NO contents in serum, reduce ET levels in plasma;(6) evidently cut down TNF- a contents in serum, superior to Vp;(7) antagonize calcium overload in TEC;(8) alleviate renal pathological changes in ARF metaphase (at 3d), advance regeneration and recovery of TEC, restore renal structure in ARF convalescence (at 5d), and better than Vp;(9) increase the expression of TEC PCNA and prepro EGFmRNA in ARF metaphase.

结果:与模型组相比,SSM能(1)提高ARF大鼠的存活率,降低24hr时Scr及BUN,改善肾功能,其疗效略优于维拉帕米;(2)减轻ARF肾脏病变程度,减少24hr肾小管坏死数及管腔内管型数;(3)对肾脏的超微结构如肾小管上皮细胞微绒毛、线粒体、内质网、肾小球上皮细胞足突、内皮细胞等形态结构均有一定的保护作用,其疗效略优于维拉帕米;(4)提高肾皮质SOD活性,降低MDA含量;(5)提高血清NO水平,同时降低血浆ET含量;(6)显著降低血清TNF-α的水平,疗效明显优于维拉帕米;(7)拮抗小管上皮细胞[Ca~(2+)]_i的升高;(8)使ARF中期(第3d时)肾组织病变较同期其它两组明显减轻,并使肾小管细胞再生修复提前,至ARF恢复期(第5d时)肾组织结构恢复重建良好;作用明显优于维拉帕米;(9)促进ARF中期肾小管上皮细胞PCNA的表达及EGF前体mRNA的合成,从而增加EGF的合成释放,而维拉帕米无此作用。

With the assistance of the chaperons such as calnexin、calreticulin and tapasin,the molecular heavy chain andβ2 micro globulin of the major histocompatibility complexare assembled together to form the steady complex which is further transported to the surface of the APC through the Golgi body.

在calnexin、calreticulin、tapasin等分子伴侣的协助下,内质网腔内的主要相容性复合体(major histocompatibilitycomplex,MHC)Ⅰ类分子重链、β2微球蛋白以及相应多肽片段聚集成较为稳定的复合物,经高尔基体被进一步转运到APC表面;MHCⅠ类分子与抗原肽的有效结合是特异性细胞免疫应答的重要的环节。

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The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。