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General symptoms such as purpure in mucous membrance and skin, bleeding of internal organs, decreasing of weight and bad mental state caused by modeling were well improved in four control groups (Chinese traditional medicine group, western medicine group, PG original formula group and PG major formula group), the peripheral PLT was increased, spleen weight and its action of phagocytosis and damage to PLT were both decreased, morrow megakaryocytes differentiation and maturation were improved and hyperplasia descended, which showed significant differences compared with the model group. Differences among the four control groups were not significant. The optimal dose ratio of PG major formula was finded out with homogeneous design software UST3.0 and multiple regression: Astragalus root 48g, Rhubarb 15g, peach kernel 1Og, Agrimony 24g.

结果:模型建立成功;中、西药对照组、紫癜颗粒核心方组与原方组小鼠对于免疫法造模所引起的皮肤粘膜紫癜、内脏出血、体重减轻、精神状态差等一般症状均有较好的改善;小鼠的外周血小板计数得到提高;脾脏均重及对血小板的吞噬破坏降低;骨髓巨核细胞分化成熟程度增高,增生活跃度降低,与模型组相比较,均有显著性差异,四个对照组之间无显著性差异,利用均匀设计UST3.0统计软件分析,进行多元逐步回归处理,筛选出紫癜颗粒核心方的最佳剂量配比为黄芪48g,大黄15g,桃仁10g,仙鹤草24g。

Malignant melanoma can occur from skin, or any internal organs, among which skin melanoma is more frequently seen, especially in the skin of legs, cunnus, and crissum. However they have been rarely reported. Malignant melanomas of the internal organs can be easily diagnosed with its specitic MRI features, while the non-melanin contained melanoma which has no imageological specific feature are more difficult to be diagnosed. Because CT examination has no specific feature, MRI should be the first choice, for the suspect patient of malignant melanoma.

恶性黑色素瘤多发生于皮肤、内脏各种组织器官,其中皮肤恶性黑色素瘤多见,以下肢、外阴、肛周最多,鲜有影像报道;发生于内脏的恶性黑色素瘤多因具备特征性的MRI信号得以诊断,而不含黑色素的恶性黑色素瘤影像表现无特征性,诊断困难;CT检查不具备特征性,对于怀疑恶性黑色素瘤的患者,应首选MRI检查。

Medication during early pregnancy can cause fetal spina bifida, cleft palate, clubfoot, small limbs, Phocomelia, umbilical prominent cheek transverse fissure, cerebral meningocele, cerebral spinal cord dysfunction, osteogenesis imperfecta and fetal death. 2, prednisone: big neat administration during early pregnancy can cause stillbirth, streaming, no brains infants, small ectopic kidney, one-eyed, cleft palate, bone deformities, such as. 3, 6-8 weeks pregnant villus chromosome examination; pregnant 16-20 weeks to do the amniotic fluid puncture in amniotic fluid cell chromosome examination; At the same time, dynamic observation of maternal alpha-fetoprotein content; attention fetal B-track general shape and structural abnormalities offal.

妊娠早期用药可致胎儿脊柱裂,腭裂,畸形足,小肢,短肢畸形,脐突出,颊横裂,脑脊膜膨出,脑脊髓功能障碍,成骨发育不全及胎儿死亡。2、强的松:妊娠早期大齐整给药可引起死产、流、无脑儿、小异位肾、独眼、腭裂、骨畸形等。3、孕6-8周取绒毛组织进行染色体检查;孕16-20周行羊水穿刺做羊水细胞的染色体检查;同时,动态观察母血中的甲胎蛋白含量;注意B超跟踪胎儿大体形态和内脏结构是否异常。

Neuroscience 2001;104:523-538.[12]Ma WL, Zhang WB, Zhang YF. Projection of the calbindin D-28k neurons receiving visceral nociceptive information from interstitial nucleus of the spinal trigeminal tract to nucleus of the solitary tract in the rat. Acta Anat Sin 2003;34:(in Chinese with English abstract).

表明CB同样存在于经INV至PB的伤害性信息传导径路内,且传递内脏伤害性信息的CB神经元多于传递躯体伤害性信息的神经元,提示含CB的神经元可能也参与了经INV中继的外周伤害性信息向PB的传递。

They did it by taking ten-week-old mice that had been bred to be free of germs and colonising their guts by feeding them with human faeces.

他们通过给初生的老鼠喂食无菌的食物,然后在他们长到10周大的时候通过给它们喂食人类排泄物在其内脏植入人类细菌。

Results The body weight, visceral fat and body weight ration, as well as the levels of blood glucose, insulin, triglyceride, total cholesterol, LDL, and total FFA, were significantly lower in high fat-fed group than in control group (P.01). The aortic tunica intima was intact, the number of foam cells was decreased, and inflammatory cells infiltrated into the med-intima smooth muscle of the n-3 PUFA group. However, with no such changes were observed in control and n-3 PUFAs groups.

结果 n-3脂肪酸组大鼠体重第1~11周均明显降低,空腹血糖、血清胰岛素、TG、TC、LDL-C、总FFA和内脏脂肪占体重百分比均明显低于HF组,HDL-C则明显高于HF组,与对照组无明显差别;n-3脂肪酸组大鼠主动脉主动脉内膜完整无内皮细胞脱落现象,内膜下泡沫细胞及炎细胞浸润减少,内膜的NF-κB呈弱阳性表达,IκBα呈阳性表达,ICAM-1和MCP-1均呈阴性或弱阳性表达。

The aortic tunica intima was intact, the number of foam cells was decreased, and inflammatory cells infiltrated into the med-intima smooth muscle of the n-3 PUFA group. However, with no such changes were observed in control and n-3 PUFAs groups. Little or no expression of NF-κB, ICAM-1 and MCP-1, and a high expression level of IκBα were detected in aortic tunica intima of the n-3 PUFA and control groups, while high expression levels of NF-κB, ICAM-1 and MCP-1, and little expression of IκBα were detected in aortic tunica intima of the high fat-fed group.

结果 n-3脂肪酸组大鼠体重第1~11周均明显降低,空腹血糖、血清胰岛素、TG、TC、LDL-C、总FFA和内脏脂肪占体重百分比均明显低于HF组,HDL-C则明显高于HF组,与对照组无明显差别;n-3脂肪酸组大鼠主动脉主动脉内膜完整无内皮细胞脱落现象,内膜下泡沫细胞及炎细胞浸润减少,内膜的NF-κB呈弱阳性表达,IκBα呈阳性表达,ICAM-1和MCP-1均呈阴性或弱阳性表达。

Fulwiler CE, Saper CP. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brian Res 1984;319:229-259.[2]Herbert H, Moga MM, Saper CB. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 1990;293:540-580.[3]Slugg RM, Light R.

三叉神经脊束间质核(interstitial nucleus of the spinal trigeminal tract, INV)为位于延髓闩平面附近三叉神经脊束内及其周围的一些核团,由中、小型梭形、圆形或卵圆形细胞组成,经三叉神经的分支和迷走、舌咽神经接受外周内脏和躯体感觉信息[6,7]。

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在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。

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