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As a result, the expression of EL mRNA was decreased too. There was a positive correlativity between them.

人脐静脉内皮细胞的增殖与人脐静脉内皮细胞内皮脂酶mRNA的表达呈正相关。

The present study analysis whether CRP could directly induce inflammation in endothelial cells, analysis what kind of effects CRP provide on cellular signal transduction in endothelial cell by gene array, and isolate LDL by one step of density gradient centrifugation, generate E-LDL by degrading LDL with multiple enzymes, direct fluorescent labeling CRP and LDL, investigate whether CRP play as intermediator in atherosclerosis.

本课题目的在于探讨CRP在脂质参与的动脉粥样硬化形成中是否起到介质作用,主要通过检测直接CRP能否诱导内皮细胞炎症表现,基因芯片分析CRP对内皮系统的细胞信号转导通路的影响,探讨CRP参与调控内皮系统炎症过程的主要机制,并且通过一步法密度梯度离心分离LDL,复合酶处理生成E-LDL,直接荧光标记CRP和LDL,分析CRP介导脂质紊乱尤其是LDL代谢产物参与动脉粥样硬化早期形成的作用。

BACKGROUND: The structural and functional impairment of endothelium cells were mainly presented by lowered endothelium activity, reduced nitrogen monoxide production, as well as increased endothelium vasoconstrictor peptide.

背景:内皮细胞发生结构损伤和功能障碍的主要特征为内皮细胞活性降低或释放的一氧化氮减少,内皮缩血管肽产生增加。

The first passage of YS-MSCs which grew in good condition was obtained, and adipogenic differentiation of YS-MSCs was induced by dexamethasone and insulin, and angioblast was induced by vascular endothelial growth factor and basic fibroblast growth factor.

取生长状态良好的第1代细胞,以地塞米松、胰岛素定向诱导卵黄囊间充质干细胞向脂肪细胞方向分化;以血管内皮生长因子和碱性成纤维细胞生长因子体外诱导其向血管内皮细胞方向分化。

Objective:To observe the effect of butterflybush flower on the anti-proliferation of vascular endothelia cell.

目的 :观察密蒙花对血管内皮细胞增生的抑制作用。方法:制备含中药密蒙花的大鼠血清,将其加入到培养的内皮细胞中,应用流式细胞仪观察细胞增生与凋亡的情况。

VEGF can specifically increase the dividing, proliferation and movement of endotheliocyte, as well as the permeability of tumor vessels, making it a crucial angiogenic factor in research.

血管的生成机制中,血管内皮生长因子(vascular endothelial growth factor,VEGF)是重要的直接作用于血管内皮细胞的生长因子,可以特异性地促进内皮细胞分裂、增殖、移动,增加血管的通透性,在血管形成中起重要作用,是目前特别受重视的血管生成因子之一。

Microarray technique was applied to look into the gene expression profiles. Ox-LDL induced HAEC apoptosis by inducing many redox- and apoptosis-related genes. Sal B prevented the ox-LDL induced endothelial damage and even induced endothelial cell proliferation.

本计划亦探讨丹参酚酸 B 抑制氧化低密度脂蛋白所造成内皮细胞的损伤与细胞附著分子表现的作用机转,亦引入微矩列技术以探讨基因表现差异之谱型,氧化低密度脂蛋白诱导许多氧化还原与细胞凋亡相关基因,丹参酚酸 B 可保护内皮细胞损伤甚至促进其增生。

These include physical characteristics, such as repulsive forces resulting from the electronegative charge of both platelet and endothelial cell membranes, and biochemical attributes, such as the synthesis and release of inhibitors of platelet activation. Platelets respond rapidly to alterations of endothelial cells and to exposure of subendothelial structures by attaching firmly to the site of the lesion.

正常情况下,循环中的血小板与血管壁内皮细胞层紧密接触但不发生黏附,是因为血管内皮细胞具有一定的活性功能,包括一些物理特性如血小板和内皮细胞膜均带有负电荷产生相互排斥作用以及生化作用如合成和释放血小板活化抑制剂。

The effects of vacuolization on the differentiation of vascular endothelial cells were analyzed from a chemical biochemistry genetics perspective using the blastodisc cells differentiation model induced by FGF with the γ-butyrolactones derivative.

从化学遗传学的角度,利用γ-丁内酯衍生物研究了成纤维细胞生长因子(fibroblast growth factor, FGF)诱导鸡胚盘细胞向血管内皮细胞分化过程中,空泡化对血管内皮细胞分化的影响。

The significantly increase of ICAM-1 mRNA expression on alveolar epithelium and pulmonary venular endotheium was also found in asthmatic rats compared with those of normal and sensitized control, but the expression of ICAM-1 mRNA on pulmonary arteriolar endothelium and bronchial epithelium showed a inceasing tendency.

原位杂交结果表明,哮喘组大鼠肺静脉内皮细胞、肺泡上皮细胞ICAM-1 mRNA表达量明显多于对照组;支气管上皮细胞、肺动脉内皮细胞粘附分子表达也有增加的趋势。

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