内皮细胞

Part Two: The effect of fruit extract on CRL-2606 production of PGE2 Effect of anthocyanin rich fruit extracts on endothelial cells'PGE2 production Epidemical experiment shows that phenolics in fruits and vegetables may prevent the occurrence of chronicle cardiovascular heart disease. To investigate the activity of fruit extracts on artery blood vessel cells, we chose CRL-2606 cell line, a normal iliac artery endothelia cells. Using indomethacin as control, we investigate the effect of blueberry extracts, blackcurrant extracts, chokeberry extracts, cyanidin3-glucoside, and malvidin3-glucoside on the PGE2 production of CRL-2606 cells.

第二部分水果提取物对人体细胞系CRL-2606产生PGE2的影响水果提取物对血管内皮细胞释放PGE2的影响流行病学调查表明，蔬菜水果中的多酚类物质具有预防慢性心血管疾病的作用，为研究水果提取物对血管细胞的作用，我们选择回肠动脉内皮细胞CRL-2606细胞系作为研究对象，以indomethacin为对照，研究了blueberry，blackcurrant，chokeberry提取物及cyanidin3-glucoside，和malvidin3-glucoside对血管内皮细胞释放PGE2的影响。

Endothelial progenitor cells are precursor cell of endothelial cells, and involved in the vascular endothelial cells repair process.

内皮祖细胞是内皮细胞的前体细胞，参与了血管内皮细胞修复过程。

Results:Expression of elastase mRNA has been found in the endothelial cells,the medial smooth muscle cells and the adventitial fibroblasts of the abdominal aorta,the lymphocytes,monocytes in blood,the tracheal hyaline cartilaginous cells,the glandular cells of the pancreas,the epithelial cells of the parotid gland and submaxillary gland,the hepatoeytes,the endothelial cells of the liver sinusoid wall,the goblet cells of the mucous membrane of the small intestine,the cardiac myocytes,the renal interstitial fibroblasts,the alveolar epithelial cells,the cerebral glial cells,the fibroblasts of the dermis oorium of the skin,the primary spermaocytes,the secondary spermaocytes and sperm in the seminfferous tubule of the testis,the lymphocytes in the spleen and thymus.

结果正常大鼠腹主动脉的内皮细胞、中膜平滑肌细胞以及血管外膜成纤维细胞，血液细胞中的淋巴细胞、单核细胞，气管透明软骨细胞，胰腺的腺细胞、腮腺、颔下腺上皮细胞，肝细胞、肝窦壁的内皮细胞，小肠黏膜杯状细胞，心肌细胞，肾间质的纤维母细胞，肺泡上皮细胞，大脑胶质细胞，皮肤真皮纤维母细胞，睾丸曲精细管内的初级精母细胞、次级精母细胞以及精子，脾脏以及胸腺的淋巴细胞等，均有弹力蛋白酶mRNA的表达。

The transter and expression of endostatin gene was analyzed by PCR, the effects of inhibition on proliferation of endothelial cell by endostatin in vitro by MTT method, and the effects on the growth of LoVo、 SGC-7901 in vitro was surveyed, and the growth of expressing endostatin LoVo、SGC-7901 cell line_in subcutaneously of nude mice was also measured.

用MTT法检测内皮抑素对内皮细胞体外增殖的抑制作用，并观察其对LoVo细胞和SGC-7901细胞体外生长的影响，观察表达内皮抑素基因的LoVo和SGC-7901细胞在裸鼠皮下种植的生长。

In this study, after incubating cultured human umb ilical vein endothelial cells with TNF-α for different time, we employed RT-PCR to assay IL-8 mRNA expression and immunocytochemical stain ing to detect NF-κB activation in HUVECs.

本文用TNF-α孵育培养的人脐静脉内皮细胞不同时间后，用RT-PCR法检测内皮细胞内IL-8 mRNA的表达，并用免疫细胞化学染色法检测内皮细胞内NF-κB的激活。

Angiogenesie and vasculogenesis comprise the mechanisms that responsible for the development of new blood vessels. Vasculogenesis is the process of in situ formation of blood vessels from endothelial progenitor cells or angioblast. Angiogenesis involves extension of the already formed primitive vasculature by the sprouting of new capillaries through migration and proliferation of previously differentiated ECs.

新血管形成的机制有血管生成和血管新生，前者是血管内皮前体细胞或成血管母细胞在原位分化为内皮细胞并形成血管的过程，后者则是已经分化的成熟内皮细胞移行并增生使原有血管延伸。

In the recent 20 years,evidences have proved that endothelial cell barrier function and vascular permeability depend on the endothelial morphologic changes and the formation of intercellular gap. It is thought that change of endothelial contractility is the last congenerous pathway of different signal transduction in permeability changes.

近二十多年来从细胞学水平的研究已证明，内皮细胞形态变化和细胞间缝隙的形成决定了内皮细胞的屏障功能和血管的通透性，内皮细胞收缩性的改变被认为是不同的信号机制导致通透性变化的最后共同通路。

By culturing human brain microvascular endothelial cells and glioma cells separatedly and simutaneously ,and then analyzing their pre- and post-cultune FasL levels, we study the effect of the grouth of glioma cells upon FasL level of human brain microvascular endothelial cells.

我们通过将人脑毛细血管内皮细胞与胶质瘤细胞分别培养及共同培养，对培养前后人脑毛细血管内皮细胞与胶质瘤细胞FasL表达水平的分析，来探讨胶质瘤细胞的生长对人脑毛细血管内皮细胞FasL表达的影响。

However, higher concentration of CRP may increase the expression of protein and mRNA of inflammatory factor in endothelial cells; 2 Higher concentration of CRP may participate in the development of inflammatory process in endothelium by the mechanism that CRP induce cells apoptosis and activate signal pathway involved in cell proliferation. 3 CRP is the member of pentraxins family, in which two faces of pentamer form a special bi-phase structure: one face is ligand recognition phase; the other face is effector phase.

总结： 1CRP是一种保守蛋白，在正常生理水平下对内皮细胞没有明显的诱导炎症发生的作用，仅在高浓度条件下有可能诱导细胞炎症相关蛋白及mRNA的表达； 2高于生理水平的CRP对内皮细胞的致炎作用主要通过诱导细胞凋亡及激活细胞增殖相关蛋白信号通路的表达； 3CRP是一种双面五聚体蛋白，结构具有特殊的二相性，能够分别结合内皮细胞和E-LDL。

Von willebrand factor is one glycosylated protein synthesized by blood vessel endothelial cell.Thrombomodulin is one glucoprotein which exists in blood vessel endothelial cell surface.Both of their levels are increased obviously when endotheliocyte is damaged,so they could be considered as the molecular markers reflecting endothelial injury.

血管性假血友病因子是血管内皮细胞合成的一种糖基化蛋白，血栓调节蛋白是位于血管内皮细胞表面的糖蛋白，内皮细胞损伤时，二者水平均显著升高，因此它们作为反映内皮损伤的分子标记物。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷