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内皮细胞

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Therefore, CRP could mediate E-LDL participating in the early stage of atherogenesis. CRP is an ancient conserved protein whose initial role as a pattern recognition molecule may have been to defend against bacterial infections, but whose present biological role appears quite complex. CRP is protective against a variety of bacterial infections and inflammatory stimuli as an opsonin. It is likely that the activity of CRP in humans is either pro- or anti-inflammatory is dependent on the context in which it is acting.

由于CRP的识别相可以结合被暴露出磷酸胆碱结构的E-LDL,形成E-LDL/CRP复合体,而内皮细胞表面能以高亲和力识别CRP的配体相,从而CRP-相性结构具有结合E-LDL,被内皮细胞捕获,引起脂质沉积和激活补体、触发炎症反应的可能性,这样可以解释早期动脉粥样硬化为何同时存在E-LDL、CRP、补体,而这三种物质在同时、同地出现绝非一个巧合。

The results indicate that using VG solution to prepare for artery bypass grafting maximally preserves endothelium. In contrast, papaverine impairs endothelium.

VG液作为血管移植过程中的保存液可以最大限度的减少内皮细胞损伤,相反用盐酸罂粟碱溶液可造成内皮细胞的明显损伤。

Seiler C, Pohl T, Wustmann K, et al. Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease: a randomized, double-blind, placebo-controlled study [J].

在体外实验以及动物实验中G-CSF能够通过激活血管内皮细胞的受体促进血管内皮细胞的迁移和增殖[18],增加心肌梗死边缘的毛细血管的密度,改善微循环,促进侧支循环的生成。

In addition, human recombinant K1-5 potently inhibited endothelial cell proliferation with no inhibition on non-endothelial cells.

MTT实验结果显示,重组人K1-5特异地抑制内皮细胞的增殖,而对非内皮细胞无抑制作用。

The relation between organ preference of tumour metastasis and heterogeneity of vascular endothelium is well known.

目前文献上对大血管内皮细胞生物学特性研究的较多,而从异质性的角度研究相对较少,有关微血管内皮细胞异质性的研究则更少。

RESULTS:(1)NO production and iNOS mRNA expression induced by LPS and TNF α was blocked by pyrrolidine dithiocarbamate or N-acetylcysteine.(2)LPS and TNF α triggered the activation and translocation of NF κ B, and PDTC or NAC inhibited the activation of NF κ B induced by LPS and TNF α.

结果:抗氧化剂可阻断内皮细胞培养体系LPS和TNFα诱导的NO生成及iNOS mRNA的表达;LPS和TNFα可诱导大鼠肺微血管内皮细胞NFκB的激活并可被抗氧化剂阻断。

It may because of no considering of the effects of blood flow shear stress.

静态条件下联合培养的内皮细胞的形态及功能特性与在体条件下均有差异,这可能是没有血流切应力对内皮细胞直接作用的结果。

The effect of magnesium on protecting cells from oxidative stress was probably related to its action on heat shock gene expression.

本研究以人脐静脉内皮细胞为研究对象,观察Mg2 +对H2 O2 诱导的热休克基因表达的影响,旨在揭示镁对内皮细胞过氧化损伤的保护作

In this study, we will use tonometry to study the effects of supplement of L-arginine on endothelial function.

本研究利用动脉波动测量仪来测量内皮细胞功能,研究补充精胺酸对内皮细胞功能改善的效果。

The results show that after lone- term load swimming training, the CEC was increased, the plasma ET content was increased and serum NO content was desreased; endothelium ultrastructure was damaged; tragacanth makes the CEC was decreased After large load exercise, the plasma ET content was decreased and serum NO was content was insreased; endothelium ultrastructure was improved.

结果表明:①大运动量运动训练后,大鼠CEC增多,血桨ET含量上升,血清NO含量下降;内皮细胞结构受损。②黄芪使大鼠大运动量训练后CEC减少,血浆ET下降,血清NO含量升高;内皮细胞超微结构改善。

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