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OPN Immuno-electron microscopy show the gold markers in thecraniopharyngioma cell of the ameloblast type be located on the endoplasmicreticulum that the swollen oncocyte afterbirth strach, from endoplasmic reticulumcreation behind secrete the outside of the afterbirth; But didnt see the gold markers inthe craniopharyngioma cell of the squamous type.

OPN免疫电镜显示成釉细胞型颅咽管瘤中金标OPN颗粒的产生位于肿瘤细胞胞浆的内质网上,由内质网产生后分泌到胞外;而在鳞状细胞型颅咽管瘤细胞中未见金标OPN颗粒,少量可见颗粒仅见于肿瘤间质中的血管内皮细胞上。

We detected the expression of VEGF mRNA by in situ hybridization and Ki 67 protein by immune histochemistry.

原位杂交法检测瘤组织血管内皮生长因子mRNA表达;免疫组化法检测瘤组织中细胞增殖核抗原Ki 67的表达。

Objective:To explore the relationship of Survivin and VEGF expression in Colonic Adenomatous polyp and Colon Cancer.

目的 探讨非家族性大肠腺瘤性息肉及腺癌中生存素及血管内皮生长因子的表达,为预测腺瘤性息肉癌变提供理论基础。

Most endothelial cells fell off, elastic fibre autolyze; the number of SMC decreased, some SMC nucleus contracted completely or depressed, typical apoptosis body were seen in later stage, muscle silk autolyzed and disappeared mostly; in outer layer saw much collagenic fiber, arranged unorderly; inflammation cells were seen in the aneurysm wall(hypertrophy cell et al.).

多数瘤壁的内皮细胞溶解脱落,不连续,弹力纤维自溶;动脉瘤血管壁均可见SMC明显减少,较多SMC染色质边聚、固缩,部分SMC核全部固缩或出现不规则凹陷,SMC核胞浆或胞核部分出现脱落或裂解成碎片,晚期可见典型的凋亡小体出现,肌丝大都自溶消失:外膜可见大量的胶原纤维,排列较紊乱;瘤壁还可见炎性细胞浸润。

Fig.3 The astrocytes in the area of gliosis around the anaplastic astrocytoma displayed Fas expression.

在多形性胶质母细胞瘤中内增生的血管内皮旦Fas强阳性,瘤细胞变为Fas阳性

RESULTS A variable degree of vascular hyalinization and glioma intercellular with enhanced tenascin immunostaining was observed.Expression of tenascin and cell proliferation in gliomas correlated positively with each other and increased with the degree of tumor malignancy.

结果 胶质瘤与其增生血管内皮细胞均表达Tenascin,Tenascin基因表达与肿瘤细胞增殖指数呈显著正相关,随胶质瘤恶性程度提高,Tenascin和Ki-67表达均增强。

The distribution of PA I-1 protein was mainly in tumor cells of high-grade astrocytomas, particularly abundant in areas of vascular proliferation and in tumor cells surrounding necr otic foci, whereas it was only weekly expressed in low-grade astrocytomas.

PAI-1蛋白主要分布在高级别星形细胞瘤的瘤细胞和内皮细胞,尤以血管增殖部位和坏死灶周围较为显著,低级别星形细胞瘤呈低表达。

Transmission electron microscope results revealed vascular endothelial cells with normal morphology in the control group and tumor cells with apparent nucleoli in the Ad-GFP group, while in the Ad-aMMP-2 group, some vascular endothelial cells exhibited chromatin pycnosis in the nucleus, forming apoptotic bodies.

透射电镜观察对组血管内皮细胞形态正常;Ad-GFP组瘤细胞大,核仁明显;Ad-aMMP-2组部分血管内皮细胞核内染色质固缩,聚积成团块状形成凋亡小体。

Recombinant endostatin is a specific inhibitor of chick chorioallantoic membrane angiogenesis and human vitelline vein endothelial cell ECV-304 proliferation. The recombinant endostatin regressed established syngeneic B16 melanoma tumor in mice.

重组内皮抑素能够抑制鸡胚尿囊膜血管生成和人脐静脉内皮细胞ECV-304的增殖,在小鼠体内实验中对黑色素瘤产生良好的抑瘤效果(P<0.01)。

Some cell dropped into the cavity and became free. Thrombosis or part organization could be seen. The internal elastic layer became thin, disappear or broken. In internal and middle layer existed fibroblasts, fibrocytes and collagen. Some of the wall indicated hyaline change, soomth muscle cell decreased greatly. The massive inflammatory cells invaded the middle and external layer. There were many foam cells in the capsule tissue. Cytoplasm was filled with fatty tissue and cholesterol. some cavities were full of thrombosis. Some thrombosis was fibrosis, the bottom was organization. The surface of the thrombosis existed red blood cell and librae.(2)Elatic fibrila staining: the internal elastic menbrane almost completely disappeared, the intact internal elastic menbran could be seen in the new small vessels.

动脉瘤管壁厚薄明显不均,全层或局部区域显著变薄向外膨出,内皮细胞空泡变性或坏死脱落,部分内皮细胞剥离并突入管腔成游离状,可见血栓形成及部分血栓机化;内弹力板变薄、消失或突然中断;在内膜及中膜部位主要为纤维母细胞、纤维细胞和大片胶原;部分动脉瘤壁呈均质状玻璃样变,平滑肌细胞明显减少;中膜和外膜可见大量的炎性细胞浸润;瘤壁组织有纤维母细胞、纤维细胞、大片胶原成分及较多泡沫细胞,胞浆内充满脂类物质及胆固醇结晶;部分动脉瘤腔内充满血栓,有的血拴已经纤维化,血栓基部机化,血栓表面有红细胞和纤维素。

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