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Vascular endothelial growth factor is a major angiogenic factor involved in physiological as well as pathological angiogenesis.

生理和病理性血管生成中,血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)是主要的血管生成因子。

Its bioactivities, such as antitumor angiogenic activity, apoptosis induction of tumor cells and endothelial cells, have made it to be a hot research spot.

它强大的抗肿瘤新生血管生成、诱导肿瘤细胞和内皮细胞凋亡等生物活性,使其成为近年来的研究热点。

Vascular endothelial growth factor is an angiogenic factor that promotes the growth of solid tumor by inducing angiogenesis.

实质固态的肿瘤细胞生长可藉由血管内皮生长因子激活血管的形成。

These angiogenic factors promote endothelial cell division and growth of capillary sprouting.

这些血管生成因子促进血管内皮细胞分裂和毛细血管出芽生长。

In addition, by activating transcription of the vascular endothelial growth factor gene, HIF-1α is considered to be a central initiator of angiogenic activity in tumors.

另外,HIF-1能激活血管内皮生长因子基因的转录活性,因而HIF-1被认为是肿瘤血管生成的重要起始因子。

Hyperlipoidemia with diabetes can raise the level of plasma endothelin and cause or worsen angiopathy.

糖尿病合并的血脂升高可提高血浆内皮素水平,引起或加重血管病变。

Objective To search for an effective approach to prevent the formation of restenosis after angioplasty.

目的 寻找抑制血管损伤后血管内皮增生的有效方法以预防介入治疗后再狭窄的发生。

I do not see atypia in the endothelial lining to suspect angiosarcoma.

没有看到内皮细胞的非典型性,因此不能怀疑为血管肉瘤。

According to the above results, we discuss the effective mechanism of Wenxin capsule anti- atherosclerosis atherosis in detail which is protecting vessel endolethial cell, regulating angiotasis, anti-platleo aggregation and inhibiting proliferation of smooth muscle cell.

依据上述结果对温心胶囊抗动脉粥样硬化作用机理进行了详细论述,认为其作用主要是通过保护血管内皮细胞、调节血管张力、抗血小板聚集及抑制平滑肌细胞增殖而实现的。

It is showed that the mechanism of XSTM was association with inhibiting expression of cell adhesion molecules of endothelium and inflammatory cell infiltrating into vessel wall, promoting fibrinolytic activity,inhibiting platelet adhesion and aggregation, regulating angiotasis, protecting the normal endothelium structure and function, inhibiting collagen hyperplasia and maintaining elasticity of vascular wall.

实验结果表明:消栓通脉颗粒剂具有显著抑制细胞黏附分子——P-选择素的表达,抑制炎性细胞的浸润,促进纤溶活性,抑制血小板黏附、聚集,调节血管张力,保护血管内皮细胞功能,抑制胶原纤维增生,维持静脉壁弹性等治疗作用。

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