内皮

It is reported that histone deacetylase 6, which is abbreviated as HDAC6, is involved in cell migration.

本文中选用血管内皮细胞为材料，研究HDAC6在血管内皮细胞迁移中的作用，并就其中的分子机制进行初步的探讨。

We observed that EPCs can regenerate damaged endothelial cells in vascular grafts in apoE-deficient mice, and that abundant vascular progenitor cells are present in the adventitia of the vessel wall.

我们的研究发现，内皮祖细胞可修复apoE缺陷小鼠血管移植物中的损伤内皮并且在动脉血管外膜中存在大量的血管祖细胞。

The positive expression rates of Tissue Inhibitors of Metalloproteinase-2 protein in the cases of involuting groups were significantly higher than those in proliferating group and vascular malformation groups and normal skin group (P.05). Its difference was significant. Conclusions: Matrix MetallProtinase-2 and Tissue Inhibitors of Metalloproteinase-2 may play an important role in the pathogenesis of hemangiomas through angiogenesis. They may have no effect on vascular malformation and normal skin

血管瘤退化期，TIMP-2表达明显升高，说明 TIMP-2与血管瘤纤维化、消退有关，其机制可能是一方面通过抑制MMP-2介导的基底膜降解而在内皮细胞迁移、聚集中起作用，另一方面直接抑制内皮细胞的增殖及迁移，使内皮细胞高频率调亡，细胞外基质增多，组织出现纤维化，最终导致血管瘤的退化。2、血管畸形和正常皮肤小血管中MMP-2和TIMP-2不表达或表达较弱，说明血管畸形和正常皮肤小血管中并不存在异常的血管生成，据此可以对血管性疾病进行分型、分期，并指导临床治疗。

It is found to relate to atherosclerosis, increasing tension of coronary artery, coronary vasospasm, coronary thromboses and vascular restenosis after percutaneous transluminal coronary angioplasty that endothelium reduce generation and re lesae of EDRF/NO.

随着内皮分泌功能的发现，人们逐渐认识到内皮不仅仅是具有单纯弥散屏障作用的细胞成份，它还有：1、调节血管舒缩；2、防止血栓形成；3、大范围的激素调节；4、促使或抑制内皮本身和血管平滑肌细胞的增生；5、调节儿茶酚胺、血小板产物的代谢和失活等作用。

The rationals of anti-angiogenesis are the following: the therapeutic target is tumor endothelial cells which are more genetically stable, more homogeneous, and with lower mutation rate; the anti-angiogenesis drugs can contact endothelial cells directly, with higher potency and lower drug barriers and side effects; the aim of anti-angiogenesis therapy is to block the oxygen and nutrition supply from vessels, instead of killing tumor r ells per se; the aim of anti-angiogenesis is to reduce tumor size instead of eradicate tumor which are different from traditional chemotherapy.

使用抗血管新生疗法根据的理论基础为以肿瘤血管的内皮细胞为治疗药物的攻击标的；肿瘤血管的内皮细胞基因比较稳定、同质性高、而且突变率低；投与的药物可以直接接触内皮细胞，减少投与药物屏障，因此增加有效投与药物的能力及减少药物副作用；以截断供应肿瘤氧气养分的血管为目标：以减小肿瘤的体积大小为目的，与传统化学疗法以根除肿瘤的目标不同。

Blood-brain barrier in tumors and peritumoral oedematous regions had the same variations in ultrastructure.

瘤体和瘤周水肿区血脑屏障超微结构变化无明显差异，内皮肿胀，毛细血管腔狭小，胶面有稀疏的绒毛样突起，内皮为无孔型，胞质内胞饮泡较多，内皮紧密连接增长，细胞连接间隙增宽，基膜完整，胶质膜缺损。

Results:Berberine inhibited HUVEC adhesion for lymphocyte when pretreated HUVEC and antagonised IL-1 and TNF-induced upregulation of HUVEC adhesion for lymphocyte.Meanwhile,IL-1-stimulated lymphocyte adhesion to HUVEC was diminished in the presence of berberine.The main molecular mechanism of berberine's function may be downregulating the expression of ICAM-1 on the HUVEC .

结果：小檗碱能抑制静息的及IL-1、TNF激活的内皮细胞与淋巴细胞间的粘附，其主要分子机制为下调内皮细胞表面粘附分子ICAM-1的表达；小檗碱能抑制IL-1激活的淋巴细胞与内皮细胞的粘附，对淋巴细胞表面粘附分子CD18的表达无影响。

The thoracic duct endothelia in vitro could remain their biological properties, and could be made a tool for studing their functions and cancer metastasis mechanism by lymphatics. The positive expression of VEGF-C in cancer cells was correlated with cancer development, it seem to be that VEGF-C induce lymphoangiogenesis through its receptor Flt-4. The Flt-4 expression of lymphatics in cancer tissues was assosiated with cancer development, it is considered that there are new lymphatics in cancer tissues.

体外培养的大鼠胸导管内皮细胞可以保持体内淋巴管内皮细胞的生物学特性，可作为研究大鼠淋巴管内皮细胞功能和进一步研究癌转移机制的体外实验材料；大鼠大肠癌组织腺体的VEGF-C表达与肿瘤进展有关，推测其通过受体Flt-4诱导淋巴管生成；Flt-4在淋巴管的阳性表达随肿瘤进展增多，推测在癌组织内存在淋巴管的新生。

Methods The rat thoracic duct endothelia were cultured and the morphology observed and identified by TEM and Factor Ⅷ-related antigen immunohistochemically. Wistar rats were used to make the animal model of primary colorectal cancer, the cancer type were appraised by HE staining and PAS Reaction. The expression of VEGF-C and its receptor Flt-4 and ICAM-1 in the cancer tissues were carried through immunohistochemistry staining and In situ hybridization.

通过体外培养大鼠胸导管内皮细胞和构建大鼠原发性大肠癌动物模型，观察内皮细胞的形态和生长状态，用透射电镜和Ⅷ因子相关抗原进行鉴定，用HE染色和过碘酸雪夫氏反应区别癌组织的类型和期别，用免疫组织化学方法和原位杂交方法研究内皮细胞和大肠癌组织的VEGF-C及其受体Flt-4和ICAM-1的表达。

Vascular endothelial cell growth factoris a kind of glucoprotein ,which has separated by culturing stellate cells of bovine glandula pituitaria in vitro by Ferrara etc. in 1989.lt can express that anxo-act vascular endothelial cell growth specificly and induce vasotropic growth ,so it is called VEGF.

血管内皮细胞生长因子(Vascular endothelial cell growth factor)是1989年Ferrara等牛垂体星状细胞体外培养分离出的一种糖蛋白，其在体内外都表现出特异性地促进血管内皮细胞的生长并诱导血管生成作用，故此称为血管内皮细胞生长因子。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。