内皮

The transform of phenotype of VSMC: The mRNA expressions of SM22α-a notate gene of contractile VSM-were all detected on normal aortas,but decreased normally when the aortas were destroyed and cultured in vitro for 10 days,especially in the serum groups,whose SM22αmRNA could not be detected by RT-PCR.Here,BQ123 can increased their expressions.This demonstrated that serum culture and the secretion of ET-1 can produce the transform of phenotype from contractile to synthesize type.

血管平滑肌表型的转化：RT-PCR检测发现，血管平滑肌收缩表型标志基因SM22α在正常血管平滑肌中都有表达，但在内皮损伤后体外培养10天的血管表达明显减弱，其中血清培养组血管基本不表达，加内皮素受体阻断剂BQ123后，各组SM22α的表达均有所上调，这表明内皮素分泌和血清培养促进了血管平滑肌的表型由收缩型向分泌型的转化。

HA increased level of NO by activating NOS after combining with H〓 and H〓 receptors; and on the one hand 5-HT caused brain microvessel endothelial cells constracting strongly, made the tight joint opening, increased the permeability of BBB, and on the other hand 5-HT increased the quantity of pinocytosis vesicle in endothelial cells and enhance the permeability of BBB after comining with 5-HT〓 receptor.

HA与H〓和H〓受体结合，激活NO合成酶，使NO含量增多而诱发BBB通透性增加；5-HT与5-HT〓受体结合，一方面引起脑微血管内皮细胞强烈收缩，使内皮细胞间的紧密连接开放，BBB通透性增高，另一方面可引起内皮细胞转运小泡增加，BBB通透性增高。

Endothelial progenitor cells are precursor cell of endothelial cells, and involved in the vascular endothelial cells repair process.

内皮祖细胞是内皮细胞的前体细胞，参与了血管内皮细胞修复过程。

Preliminary study revealed the devascular effect of PYM correlated with the inhibitory of vascular endothelial cells.

一、PYM抑制人脐静脉内皮细胞生长的体外研究目的通过体外实验观察PYM对人脐静脉内皮细胞株一一一石CV304细胞生长、增殖和凋亡的影响，以证实PYM对血管内皮细胞的抑制作用及了解相关的影响因素。

Results ec was cultured and subcultured successfully. vascular endothelial cells show slabstone appearance enchased arrange under phase contrast microscope. the growth appearance was showed under sem. some dispersive high electron density of rod type weible palade body were seen under tem.

结果 培养出血管内皮细胞并传代，倒置显微镜下血管内皮细胞呈"鹅卵石"形态，扫描电镜显示"铺路石"样生长，透射电镜可见内皮细胞特征性w p小体，免疫组织化学鉴定ⅷ因子。

The transter and expression of endostatin gene was analyzed by PCR, the effects of inhibition on proliferation of endothelial cell by endostatin in vitro by MTT method, and the effects on the growth of LoVo、 SGC-7901 in vitro was surveyed, and the growth of expressing endostatin LoVo、SGC-7901 cell line_in subcutaneously of nude mice was also measured.

用MTT法检测内皮抑素对内皮细胞体外增殖的抑制作用，并观察其对LoVo细胞和SGC-7901细胞体外生长的影响，观察表达内皮抑素基因的LoVo和SGC-7901细胞在裸鼠皮下种植的生长。

In this study, after incubating cultured human umb ilical vein endothelial cells with TNF-α for different time, we employed RT-PCR to assay IL-8 mRNA expression and immunocytochemical stain ing to detect NF-κB activation in HUVECs.

本文用TNF-α孵育培养的人脐静脉内皮细胞不同时间后，用RT-PCR法检测内皮细胞内IL-8 mRNA的表达，并用免疫细胞化学染色法检测内皮细胞内NF-κB的激活。

BACKGROUND: The structural and functional impairment of endothelium cells were mainly presented by lowered endothelium activity, reduced nitrogen monoxide production, as well as increased endothelium vasoconstrictor peptide.

背景：内皮细胞发生结构损伤和功能障碍的主要特征为内皮细胞活性降低或释放的一氧化氮减少，内皮缩血管肽产生增加。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

Angiogenesie and vasculogenesis comprise the mechanisms that responsible for the development of new blood vessels. Vasculogenesis is the process of in situ formation of blood vessels from endothelial progenitor cells or angioblast. Angiogenesis involves extension of the already formed primitive vasculature by the sprouting of new capillaries through migration and proliferation of previously differentiated ECs.

新血管形成的机制有血管生成和血管新生，前者是血管内皮前体细胞或成血管母细胞在原位分化为内皮细胞并形成血管的过程，后者则是已经分化的成熟内皮细胞移行并增生使原有血管延伸。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。