内原

AIM: To investigate the expression and role of Smad5 protein in mediating transforming growth factor-β superfamily signaling transduction in human dental papillae cells.

目的：观察Smad5蛋白在体外原代培养的人牙乳头细胞内的表达及其在转化生长因子-β超家族信号转导中的作用。

Derma in experimental group became thinner,elastic fibers of papillar layer became hypertrophic,vessel density under skin was significantly greater than that of normal group,and collagen fibers of derma were bulky and lined like wave.

2实验组真皮变薄，乳头层弹力纤维大量增生，皮下血管网密度明显大于对照组，真皮网状层、真皮内胶原纤维粗大呈波浪状排列。

Background and Objective: Intracerebral hemorrhage is non- traumatic and cerebral parenchymal haemorrhage accounting for 5%-30% in all stroke.

背景与目的：ICH是指原发于脑实质内的、非创伤性出血，占所有卒中的5%～30%。

Methods］Systemic injection of KA results in forming animal model of epileptic susceptibility, at the same time, treated them with SVHRP,observed the epileptic behavioral processes according Racine seizure stage, and investigated the expression of PENK mRNA by means of RT-PCR.

方法］大鼠颈部皮下注射红藻氨酸，制备癫痫敏感性动物模型后，给予蝎毒耐热蛋白（scorpion venom heat resistant protein，SVHRP）进行干预。通过观察癫痫行为学表现检测SVHRP对癫痫敏感性形成的影响，同时应用RT-PCR技术检测不同处理组大鼠海马内前脑啡肽原表达的变化。

Compounds were identified by means of physic-chemical property and spectral data including three new compounds: platyphyllin A (1), neochlorgeniclatone (2),(2E,6Z)-2,6-dimethyl-8-O-β-D-glucosyl-2,6-octadienoic acid (3). The known compounds included cyclic diarylheptanoids, phenylic acid, ect.

从白桦叶的水提取物中，利用各种色谱分离手段(硅胶柱色谱、聚酰胺柱色谱、凝胶柱色谱及制备薄层色谱等)，分离得到28个化合物，通过理化性质及各种波谱数据(NMR，MS，IR，etc)鉴定了23个化合物的结构，其中新化合物三个：platyphyllin A(1)，新绿原酸内酯(neochlorgeniclatone，2)，(2E，6Z)-2，6-二甲基-8-O--2，6-辛二烯酸(2E，6Z-2，6-dimethyl-8-O-β-D-glucosyl-2，6-octadienoic acid，3。

Erve growth factor can combine with its" receptor (one of tyrosine protein kinase receptor coded by proto - oncogene tyrosine kinase, TrkA), Causing the molecule of receptors to gather on the cell surface, and the tyrosine protein in cytoplasmic domain may be activated, three tyrosine base in the kinase domain of its" receptor and two tyrosine base at other domain be phosphated, thus, phosphated tyrosine receptor kinase became the bracket which absorb all kinds of connective proteins and kinases.

GF与其酪氨酸受体激酶受体(由原癌基因trk编码的一种酪氨酸蛋白激酶受体，TrkA)相结合，引起受体分子在细胞表面发生二聚体化，然后受体细胞内结构上酪氨酸活性被激活，使受体自身结构中位于激酶结构域的三个酪氨酸残基及在此结构域外的两个酪氨酸残基发生自身磷酸化，这样，磷酸化的酪氨酸受体激酶A便成为吸收各种连接蛋白质和酶的支架。

objective to study the changes of t-pa and t-pa inhibitorduring the acute stage of cor pulmonale.methods to measure the plasmatic activity of t-pa and pai by chrom-substrate in60cases of cor pulmonale,compared with the corresponding index of55cases in the control group.results pai was significantly higher in acute stage than in remission stage of corpulmonale,and t-pa was lower in remission stage than in acute stage.the difference was significant（p.01）.conclusion the unbalance between t-pa and pai can promote the formation of micro-thrombus and further exacerbate high pulmonary pressure.

目的 探讨血浆组织型纤溶酶原激活物及t-pa抑制物在肺心病急性加重期的变化。方法用发色底物法测定60例肺心病急性加重期的血浆t-pa及pai的活性，并与对照组55例肺心病缓解期的相应指标作比较。结果肺心病急性加重期患者pai显著高于肺心病缓解期，而t-pa低于肺心病缓解期，其差异具有非常显著性（p.01）。结论 t-pa及pai关系失衡，有助于动脉内微血栓形成，促进或加重肺动脉高压的形成。

86 hypertensive patients with ischemic stroke . 85 hypertensive patients without ischemic stroke and 90 healthy blood donors were randomly enrolled in this trial . p-fibrinogen gene -455G/A polymorphy was analyzed from all subjects by polymerase chain reaction with restrictive enzyme HaeIII(PCR-RFLP method).

随机抽取住院高血压脑梗死病人86例，高血压非脑梗死病人85例，健康老年人90例，β-纤维蛋白原基因启动子区域-455G／A的多态性分析用多聚酶链反应加HaeⅢ内切酶检测。

Result: Porosis and inflammatory cell infiltration in the spinal cord, rupture of muscle bundles, hypertrophia and over growth of muscle cells and collagens, and inflammatory cell infiltration in the bladder wall could been seen under HE dyeing. Nissal dyeing showed the decrease of neurons at the injured segment, upper and lower segments of the spinal cord. Result of immunohistochemistry showed there were caspase-3 positive expression in all the segments. The injured spinal cord and bladder expressed significantly more caspase-3 positive results (P.0l), upper and lower segments were lower than the injured segments (P.01), but higher than the control team (P.0l).

结果：HE染色发现脊髓损伤后脊髓内空洞形成、炎性细胞浸润等病理学变化，膀胱壁中可见到肌束断裂、肌细胞肥大增生、胶原增生、炎性细胞浸润等病理学改变；Nissal染色显示脊髓损伤后损伤节段及其上、下节段均出现神经元数量的减少；免疫组化结果表明3组均有不同程度的caspase-3表达，损伤组脊髓和膀胱内膜caspase-3表达较正常组显著增加(P.01)，损伤上段及下段caspase-3表达较损伤节段为少(P.01)，但均高于正常对照组(P.01)。

In male, FSH and LH immunopositive substance was distributed in the right and left part of procerebrum at flying stage.

本研究首次证实白蚁婚飞行为与其前脑部神经活动有密切关系；原癌基因c一fos在调节与性行为有关的前脑神经细胞核内基因表达方面有重要作用。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。