内分泌病

Results and Conclusions: The polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome is a rare multisystemic disorder associated with plasma cell dyscrasia.

结果和结论：POEMS综合徵是以进行性多神经病变、脏器肿大、内分泌病、M蛋白血症和皮肤改变以及浆细胞恶性增生为特徵的一种较少见的系统性疾病。

Results In addition to the typical characteristics of polyneuropathy (100%), organomegaly (92%), endocrinopathy (86%), monoclonal plasmaproliferative disorder (100%) and skin changes (86%), the patients of POEMS syndrome also have other important features including extravascular volume overload (97%), papilledema (57%) and bone lesions (25%).

结果 POEMS综合征患者除了具有多发性神经病(100%)、器官肿大(92%)、内分泌病(86%)、单克隆浆细胞增生(100%)和皮肤病变(86%)的典型临床特征外，还常常表现为血管外容量过负荷(97%)、视乳头水肿(57%)和骨病变(25%)。

Clinical and molecular profile of a new series of patients with immune dysregulation, poly endocrinopathy, enteropathy, and X-linked syndrome: Inconsistent correlation between forkhead box protein 3 (FOXP3) expression and disease severity.

一组患有免疫失调节，多内分泌病，肠病，以及X-连锁综合征的患者的临床状况及分子基础：疾病严重性与FOXP3蛋白表达水平不一致。

These diseases can occur together in defined syndromes with distinct pathophysiology and characteristics: autoimmune polyendocrine syndrome I, autoimmune polyendocrine syndrome II, and the immunodysregulation polyendocrinopathy enteropathy X-linked syndrome.

这些疾病可以与一些有不同病生理和特征的确定的综合症一起发生：多发性自身免疫性内分泌综合征1型，多发性自身免疫性内分泌综合征2型，免疫调节不能性多发性内分泌腺X-连锁肠病综合征。

The results showed that LRK could significantly inhibit the mammary hyperplasia caused by estrin, reduce the content of serum 〓, raise P level, promote the production of DA in hypothalamus and mammary tissue, decrease the release of 5-HT, inhibit the secretion of serum PRL, reduce the sensitivity of mammary tissue to estrin and progestogen, prevent the expression of mammary tissue on PCNA, the effect was equal to triphenylamine oxide, obviously superior to the control group of Ru Zeng Ning.

通过实验研究，建立了具有肾虚肝郁证侯群的乳腺增生病理模型，利用免疫组化技术、图像分析系统、荧光分光光度法、放射免疫法等现代医学研究方法，从病理形态学、医用体视学、神经内分泌学、阴道细胞学等方面，观察了利乳康口服液对模型动物整体状态、乳腺组织病理形态、血清激素、神经递质以及卵巢功能的影响，结果表明利乳康口服液能明显抑制雌激素引起的乳腺组织增生，降低血清E〓含量，升高P水平，促进下丘脑及乳腺组织中DA的产生，减少5-HT释放，抑制血清PRL分泌，降低乳腺组织对雌、孕激素的敏感性，阻止乳腺组织PCNA的表达，其效应与三苯氧胺相当，明显优于乳增宁对照组；另外，利乳康口服液还能缓解模型动物肾虚肝郁证侯群，增加其体重，调节其整体状况，改善模型动物不规则动情周期，减轻其子宫及卵巢的病变，抑制子宫内膜的过度增长，调节卵巢功能，揭示了中药利乳康口服液对神经内分泌和卵巢功能的整体调控作用，以及对本病发生、发展的预防作用

Not only it impairs patients" genital health and Quality of life, but also is associated with an increased risk of type 2 diabetes, endometrial carcinoma, hyperlipemia, hyperpiesia, cardiovascular and cerebrovascular events. Up to now, precise pathogenesy of PCOS is yet unknown. The modern medicine indicates the etiopathogenisis of PCOS related to hereditism, endocrinology, immunology, metabolism and so on. The main features are hyperandrogenism and hyperinsulinemia, the correlation and between the above factors and how they inference PCOS are still unclear. In the view point of Traditional Chinese Medicine ,PCOS classifies to "menopathy","infertility" and "Zhengjia , its occurrence exists a close relationship with dysfunction of liver, kidney, spleen and further inducing deficiency, sputum, sluggish stagnant and fire. Many scholars insist that pathogenesis of PCOS is a renal deficiency plus phlegmatic hygrosis. However, after many years clinical observation.

随着研究的不断深入，PCOS日益显示出其复杂性和重要性；他不仅影响到患者的生殖健康及生存质量，而且其异常的激素环境使该类患者对子宫内膜癌、高血压、高血脂及心脑血管意外等病发生危险明显增加；但目前该病的确切发病机制尚不十分清楚，现代医学认为其病因涉及到遗传、内分泌、免疫、代谢等多个方面，以高雄激素血症与高胰岛素血症为主要特征，二者在PCOS发病中的确切作用，目前尚不清楚；PCOS相当于祖国医学的"月经病""不孕""癥瘕"等范畴，本病的发生与肝、肾、脾功能失调导致虚、痰、瘀、火有关。

With the development of molecular biology,a lot of genes for the inherited endocrine and metabolic diseases have been reported.Meanwhile,more and more endocrine and metabolic diseases caused by monogenic mutations have been discovered.

随着分子生物学技术的发展，相当多的遗传性内分泌代谢病的致病基因相继被报道；同时，越来越多的单基因突变所致的内分泌代谢疾病被发现。

Patient's age was young,34.22±5.07 years(14～64).The female:male ratio was 1.6:1,while in foreign countries the corresponding figures were 58±14 years (18～87);and 2.7:1 2.The outstanding bony change was cystic osteitis fibrosa,found in 78.7% of the cases(8%～44% in foreigners). 3.37.5% of the cases showed a normal serum calcium level,wh...

收集我国1949~1975年文献报告共得48例，而在国外则常数以百计〔""。1963年我们开始临床内分泌外科工作曾作过初步报道，截至1984年共收治47例，观察有关本病的某些特点，加以总结并进一步报道，以期加深对本病的

Not only it impairs patients" genital health and Quality of life, but also is associated with an increased risk of type 2 diabetes, endometrial carcinoma, hyperlipemia, hyperpiesia, cardiovascular and cerebrovascular events. Up to now, precise pathogenesy of PCOS is yet unknown. The modern medicine indicates the etiopathogenisis of PCOS related to hereditism, endocrinology, immunology, metabolism and so on. The main features are hyperandrogenism and hyperinsulinemia, the correlation and between the above factors and how they inference PCOS are still unclear. In the view point of Traditional Chinese Medicine ,PCOS classifies to "menopathy","infertility" and "Zhengjia , its occurrence exists a close relationship with dysfunction of liver, kidney, spleen and further inducing deficiency, sputum, sluggish stagnant and fire. Many scholars insist that pathogenesis of PCOS is a renal deficiency plus phlegmatic hygrosis. However, after many years clinical observation.

随着研究的不断深入，PCOS日益显示出其复杂性和重要性；他不仅影响到患者的生殖健康及生存质量，而且其异常的激素环境使该类患者对子宫内膜癌、高血压、高血脂及心脑血管意外等病发生危险明显增加；但目前该病的确切发病机制尚不十分清楚，现代医学认为其病因涉及到遗传、内分泌、免疫、代谢等多个方面，以高雄激素血症与高胰岛素血症为主要特征，二者在PCOS发病中的确切作用，目前尚不清楚；PCOS相当于祖国医学的&月经病&&不孕&&癥瘕&等范畴，本病的发生与肝、肾、脾功能失调导致虚、痰、瘀、火有关。

We should keep this diagnosis in mind when a patient presents with combined ophthalmologic, neurological or neuroendocrinological complaints.

当病患有眼睛，神经症状及神经内分泌方面的问题时，我们必须考虑到神经性类肉瘤病。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。