其类似物

The efficacy of lamivudine, the first nucleoside analogue available, is limited by the high incidence of resistance.

拉米夫定的有效性，获得了第一个核苷类似物抗病毒药物，但其局限性在于具有较高的药物抵抗的发生率。

In order to study its structure function relation, seven peptide segments and five analogues were designed and synthesized.

为进一步研究其结构与活性的关系，设计并合成了它的7个肽片段和5个类似物。

The present paper take the purine synonym kui zuo lin as a parent nucleus, separately in its 4 and 7 introduction structure diverse substituted benzene amino and the flexible side chain, designed a series of 4- substitution anilino-- 6- methoxy - 7-(2- hydroxyl to substitute for third oxygen radical) kui zuo lin a kind of compound.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。

This Mets-analysis demonstrates that SSAs are effective in treatment of Graves ophthalmopathy and in reduction of proptosis, and it is equally effctive as glucocorticoid.

生长抑素类似物治疗Graves眼病有效，能减轻突眼的程度，其疗效与糖皮质激素的作用相当。

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Then, a series of saponin analogues were designed and synthesized as the major work in this dissertation.

重点设计并合成了一系列皂苷类似物，并对其进行了体外活性研究。

The Chandra data show the shape and extent of the high-energy emission in the central region. By studying W28 and others like it, astronomers hope to better understand the complexities involved when a star explodes in a crowded neighborhood.

钱德拉的数据同时也展现了中心高能发射物形状和程度，通过研究W82和其类似天体，天文学家希望能更好的理解当一颗处于拥挤环境中的恒星爆炸时的复杂性

First, two chiral glycerol derivatives were synthesized in twelve steps of reactions from natural tartaric acid.

据此，本论文确定ω-氨基溶血磷脂酸为和载体相连的LPA类似物，并尝试性地对其进行了合成。

However, poly analogs cannot be obtained through the polymerization of the obvious parent molecule, vinyl amine, because vinyl amine is unstable with respect to its imine tautomer, ethylimine.

然而，聚类似物不能获得通过聚合明显的母公司分子，乙烯胺，因为乙烯胺是不稳定与尊重其亚胺互变异构体， ethylimine 。

A soluble polymer analogue was realized by using a 1,2,4,5-tetralkoxy benzene in the place of dialkyl benzenes, and its properties are compared to a nonfluorinated analogue.

一种可溶性聚合物模拟实现用1，2，4，5- tetralkoxy苯取代烷基苯，其性能相对于非氟类似物。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失