其类似物

Based on the work of the first part, we studied the possibility of allyl as a protection group in the synthesis of oligonucleotides consisting in some unstable nucleotide analogues, such as nueleoside carbonate and sulfite.

在寡核苷酸的类似物中，碳酸酯及亚硫酸酯在碱性条件下的不稳定性使其在合成上有一定的困难，这限制了对它们的性质作进一步的研究。

Objective: Effect of plant Coleus Forskohlii active monomer ISOF and CF-E on ALI in vitro was studied. Moreover, the mechanism about them was investigated primarily.

目的：从细胞与分子水平上研究滇产毛喉鞘蕊花提取的单体异佛司可林及有效部位(CF-E，主要为佛司可林的类似物)抗急性肺损伤的作用，初步探讨其作用机制。

The sequence specific assay established in the present study can be used for accurate quantitation of GH mRNA in cyprinid species, and contribute to a better understanding of the regulation of GH mRNA expression in teleosts.

这表明：性类固醇激素不能在转录水平上对生长激素基因表达进行调控，但能够加强促性腺激素释放激素类似物在刺激生长激素分泌及调控其基因转录水平方面的作用。

In this study, curcumin and 23 novel analogs were used to screen for inhibition of matrix metalloproteinase-9 (MMP-9) activities, protein and gene expression of highly metastatic HT-1080 human fibrosarcoma cells to explore the mechanisms of action.

本篇研究使用姜黄素及其二十三个结构类似物对於具有高度转移活性的人类纤维肉瘤细胞(HT-1080)进行MMP-9活性、蛋白质及基因表现抑制活性筛选，并探讨其可能机制。

Tenofovir disoproxil fumarate, a congender of adefovir that is used in the treatment of HIV infected patients, has recently been shown to also be effective in patients with lamivudine-resistant HBV infection.

替诺福韦是阿得福韦的类似物，被用于治疗HIV感染的患者，进来发现其也可以有效的治疗拉米夫定抵抗型的HBV感染。

AIM: To design and synthesize a new analogue of salidroside-tyrosol galactoside, observe its protective effects on focal cerebral and cardiac ischemia/reperfusion injuries and compare its protective effects with those of salidroside.

目的： 设计合成一种新的红景天苷(salidroside，SDS)类似物—酪醇半乳糖苷(tyrosol galactoside，TG)，进一步探讨其对心脑的保护作用并与红景天苷的保护作用进行比较。

To explore the differentiation potency of skin analog reconstructed with ES cell-derived epidermal stem cells and dermal analog in hypodermis.

作者：刘爱军，黄锦桃，李海标以ES细胞源性表皮干细胞为种子细胞构建皮肤类似物，探讨其在皮下的分化潜能。

Aim To design and synthesize limonene analogues, and to assess their antitumor activity in vitro.

目的设计并合成柠檬烯类似物，并对其体外抗癌活性进行初步的评价。

The results show that the adsorption capacity of the monolith for the template was found to be much stronger than 2-hydroxybenzoic acid.

吸附等温线表明，印迹整体柱对模板分子的吸附能力比其结构类似物的吸附能力强。

The conclusions were as follows: theνO-H andνC=O IR absorption maxima shifted towards higher wave numbers after imprinting 17β-estradiol on TFMAA-co-TRIM copolymer with the red shift of theνO-H groups being apparent after precipitation polymerization for 16h while that forνC=O groups being observed after polymerization for 24h. A strong interaction between TFMAA and 17β-estradiol was confirmed by the high selectivity for 17β-estradiol, as indicted by the values of the separation factor of isomers of 17β-estradiol/17α-estradiol (2.28) and the imprinted factor (3.01). Particle diameter of TFMAA-co-TRIM polymer was between 300 nm and 1.5μm, which suited well for solid phase sorbent throughout at low column pressure. The recognition of imprinting TFMAA-co-TRIM polymer for sterol molecules was driven by enthalpy eluted with acetronitile, and low temperature was in favor of the separation of sterol structure analogues on imprinting column. TFMAA-co-TRIM polymer possessed of determinate anti-heat stability, with melting point beginning at 255.84℃, Tp=257.40℃, control TFMAA-co-TRIM polymer and imprinting TFMAA-co-TRIM polymer were respectively decompounded at 267.79℃and 343.11℃, and solid micro-extraction noddle prepared by the special polymerization also showed definite recognition for 17β-estradiol by GC/MS detecting at 270℃. By selection of various washing and elution solvents, elution reagents of close polymerization system were of more advantage in template molecules retention and recognition on molecularly imprinted solid phase extraction column. At a certain extent, progesterone, 17α-estradiol, 17β-estradiol and 4-androstene-3, 17-dione could be intercepted on the MISPE column. Especially, MISPE had high selectivity for progesterone, and imprinting TFMAA-co-TRIM polymer could achieve adsorption balance within 50 min by absorption kinetics test for 17β-estradiol. However, MISPE column showed better selectivity and enrichment property for 17β-estradiol than C18 and CSPE columns according to the data from HPLC and GC/MS analyses. Recovery of 17β-estradiol on MISPE column was up to 85.5% while when prime extracting solution of milk powder was sampled, the recovery of CSPE and C18 columns were 43.7% and 30.7%, respectively.

通过研究阐明：紫外聚合产物TFMAA-co-TRIM中的νO-H振动吸收峰在聚合16h后红移，νC=O振动吸收峰在聚合24h后红移；TFMAA-co-TRIM对雌二醇异构体的印迹因子达到了3.01，α为2.28，优于其它功能单体参与得到的聚合物识别特性；TFMAA-co-TRIM聚合物粒径介于300 nm至1.5μm之间，作为色谱固定相具有良好的通量和低的柱压；在乙腈流动相中，TFMAA-co-TRIM分子印迹固定相的分离过程主要被焓驱动，低温有利于分子印迹固定相分离甾醇结构类似物；TFMAA-co-TRIM分子印迹聚合物在255.84℃时开始熔融，Tp=257.40℃，聚合物CP的降解温度在267.79℃，MIP降解温度在343.11℃，制备的固相微萃取头初步经GC/MS 270℃的耐热性测定；不同的洗提溶剂筛选证明了选择接近聚合溶剂的洗脱体系更有利于MISPE发挥识别效应；分子印迹固相萃取柱对孕酮、17α-雌二醇、17β-雌二醇和雄烯二酮都具有不同程度的保留特性，可作为此类化合物的吸附材料，特别对孕酮强保留的富集特性，可作为孕酮的选择性识别吸附剂，其分子印迹聚合物对17β-雌二醇的吸附动力学测定显示在50 min内基本达到吸附平衡，具有作为传感器核心敏感材料的潜力；对比萃取奶粉中17β-雌二醇性能，MISPE柱比非分子印迹固相萃取柱和C18柱具有更高的保留，回收率依次为85.5%，43.7%和30.7%。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了