关节病理学

Objective To aid at the histological evaluation of hyaline cartilage and bone, we provide a simple and rapid method of tissue preparation for articular joint histology. Methods A defect 3 mm in diameter and 4 mm in depth, penetrating the subchondral bone plate, was created on the medial femoral condyle of rabbit knee using a stainless-steel electric drill.

目的：探索一种简单、快速的制作兔膝关节骨组织石蜡切片的方法，观察关节软骨和骨组织微观结构，为制备高质量骨组织石蜡切片和组织病理学研究提供实验基础。

Objective: 1）Observe the feasibility of the model of egg protein induced leporid rheumatoid arthritis. 2）By pathology observation of pathological synovium, find out the transformation of AIA leporid arthral synovium after urea injection and the infection to local and general disease. 3）Find out if urea has obvious side-effect to arthral cartilage. 4）Mensurate the VEGF expression of synovium, investigate the effect of VEGF on rheumatoid arthritis and the effect of urea on VEGF expression.

研究目的：（1）观察鸡卵蛋白诱导性兔类风湿性关节炎模型实验方法的可行性；（2）通过病变滑膜组织病理学观察，了解注射尿素后AIA兔关节滑膜病理形态的变化；以及对局部及全身病情的影响；（3）观察尿素对关节软骨是否有明显毒副作用；（4）测定滑膜VEGF表达，初步探讨VEGF在RA病变发展中的作用及注射尿素对VEGF表达的影响。

Results Both dosages of 153 Sm have an initial pro-i nflammatory effects during one week after injection,and then resulted in reducti on of joint diameter and skin surface temperature.153Sm (3.7×107 Bq) s howed a more alleviation than 153 Sm (1.85×107 Bq) in respect of macr oscopic and histologic changes.

注射153Sm(1.85×107Bq)导致一过性炎症反应，7 d后肿胀和局部发热缓解，并持续36 d.153Sm(3.7×107Bq)同样有一过性炎症反应，7 d后缓解，关节直径和皮肤温度较对侧关节有差异(P＜0.05)，并一直持续至处死前未改变。而大体形态学和病理学可见滑膜炎减轻，其指标与对侧相比差异有显著性(P＜0.05)。

Objective To furnish an experimental basis of the early effects of rheumatoid arthritis on the temporomandibular joint by observing the histopathological changes of TMJ in the early stage of polyarthritis rats.

目的 观察大鼠多发性关节炎（polyarthritis，PA）早期颞下颌关节(temporomandibular joint，TMJ)的组织病理学变化，为研究类风湿关节炎（rheumatoid arthritis，RA）早期对TMJ的影响提供实验依据。

Anti-CCII antibody level was higher in experiment group than that in the normal group by ELISA(P.001). Besides, typical arthritis pathology was showed by roentgenography and histopathology.

与正常对照组相比，实验组大鼠脚踝与脚趾均有明显的肿胀；ELISA结果显示：实验组大鼠血清中抗CCII抗体水平较正常对照组明显高(P.001)； X线摄片结果和病理学分析结果显示，实验组大鼠的关节呈现典型的RA关节样病变和病理组织学特征。

The pathological findings showed that ZBT could alliviate the synovial tissues inflammatory congestion, edema, remit the inflammatory cell infiltration and inhibit the proliferation of synovial cells, therefore reduce the degree of destruction of the articular cartilage and subcartilaginous bone tissue. Inhibited the disablement of the woulded limbs.

结果：止痹痛药酒能轻模型鼠关节肿胀度，对免疫注射后继发病变具有良好的治疗作用，说明该药具有抗炎免疫作用，病理学观察证实该药能减轻关节滑膜的充血水肿和炎细胞浸润、抑制滑膜细胞增生，减轻关节软骨和软骨下骨组织的破坏程度，抑制模型鼠患肢的致残。

The comparative observation of pathology of chicken gout and duck gout revealed that chicken gout was chronic disease , consisting of visceral and articular gout simultaneously , which developed into a significant amount of gouty tophus in the kidney area .

通过对鸡痛风和鸭痛风病例的病理学变化观察发现，鸡痛风是以内脏型和关节型同时发生的一种痛风，并且在肾脏形成大量痛风结节，呈现慢性经过；鸭痛风是一种内脏型痛风，呈亚急性痛风，并且在肾脏和脾脏形成少量痛风结节。

Hemarthrosis and destruction of the disc played an important role in the pathogenesis of traumatic diseases in TMJs. Part 3 A comparative study of the histological changes in the TMJ after different treatment of unilateral fractures in the lambs The histological changes were recorded in the TMJ after different treatment of unilateral fractures.

实验三 创伤后应用不同方法治疗单侧髁状突骨折后TMJ组织病理学改变的比较研究本实验采用颏部撞击法造成幼年山羊的双侧TMJ损伤后，在左侧髁颈部切断髁状突，模拟单侧髁状突骨折，并应用不同的治疗方法进行处理，观察其关节结构的变化情况。

OA was caused in the rabbit by resecting the cartilage between diaphsis and condyle of proximal tibia.

针对临床中大量的继发性膝关节OA病例，孟和教授强调了生物力学在病因学、病理学及治疗学中的重要地位：&尽管有酶类及免疫反应的参予降低了关节软骨的屈服强度，但要磨损到骨质外露却离不开应力的作用&。

Atment rabbit knee joint to be straight, from the biological mechanics and the pathology angle discussion massage regarding the Knee joint osteoarthritis rabbits ligament, the articular cartilage performance function, builds the foundation for the further thorough research.

采用推拿手法治疗，从生物力学和病理学的角度探讨推拿对于膝关节骨性关节炎兔的关节活动度、髌韧带、关节软骨性能的作用，为进一步的深入研究打下基础。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。