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TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

. This is the first study to compare employment status following Patellofemoral, Unicompartmental knee and Total Knee Replacement.

这是第一个进行髌骨关节置换、单髁关节置换及全膝关节置换后就业情况的研究。

Measurement of patellofemoral alignment according to the surface of cartilage was more accurately than that of osseous contour.

通过MRI测量髌股关节软骨面的对合，能使髌股关节紊乱的诊断和治疗得以有效地进行。

A retrospective study of a consecutive cohort of 109 patients, under the age of 60, who had either a Patellofemoral replacement, Unicompartmental replacement or a Total knee replacement.

这是一个回顾性队列研究。患者109名，年龄60岁以下，进行过髌骨关节置换或单髁关节置换或全膝关节置换。

The geometry and anatomy of the surface of the cartilage and corresponding subchondral osseous contours of patellofemoral joint were different.

根据髌股关节的软骨来测量各种数据能更客观准确地评估髌股关节对合的情况。

Objective To determine the expression of advanced glycation end products binding proteins on human joint synovial cells for elucidating the pathobiological effects of β2m modified with AGE(AGE-β2m) on joint resident cells.

摘 要：目的进一步探讨晚期糖基化终产物修饰的β2微球蛋白(AGE-β2m)对关节固有细胞的生物学作用，确定人类关节滑膜细胞是否表达对AGE特异的受体。

Methods Fractures of tibial plateau in 42 cases were treated with open reduction.In addition,the stripped and lifted parts of articular cartilage were reposited and fixed with silk thread or thin wire,and the cartilage-uncovered articular surface due to defect of cartilage was covered with the bone morphogenetic protein-fibrin sealant or repaired with the pediculated periosteum flap,respectively.

对42例胫骨平台骨折除重视骨折复位外，对部分剥脱、掀起的关节软骨予以复位并采用丝线或细钢丝抽出缝合修复，对缺如软骨裸露关节面，根据其大小、深浅分别用骨形成蛋白-纤维蛋白粘合剂复合片或附以带蒂骨膜瓣翻转修复。

By observing and analyzing the test results for the clinical application of acupuncture to provide some theoretical basis and experimental data,as well as the treatment of periarthritis of shoulder to provide more simple and effective ideas and approaches to treatment.

通过对试验结果的观察分析，为针灸治疗肩关节周围炎的临床应用提供一些理论依据和实验数据，也为肩关节周围炎的治疗提供更简捷有效的思路和治疗方法。

In this research project, 60 scapulohumeral periarthritis patients were divided into 2 groups: thermoacupuncture group and acupuncture group.

本研究将临床60例肩周炎患者分为温针组和针刺组，通过对两组病例治疗前后的肩关节运动功能、疼痛评定、肩关节活动度以及临床疗效的观察，以对温针治疗肩周炎的临床疗效作出客观的评价。

The main reser-vation about manipulation is the potential risk of uncontrolled articular and periarticular damage.

主要保留，操作是未管制的关节和关节周围的损伤潜在的风险。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。