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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

All the thoughts and experience of the world have etched and molded there, in that which they have of power to refine and make expressive the outward form, the animalism of Greece, the lust of Rome, the mysticism of the middle ages with its spiritual ambition and imaginative loves, the return of the Pagan world, the sins of the Borgias.

世上所有思想和全部经验都蚀刻、浇铸般地应用于此了，她外在的形中，希腊的兽性，罗马的肉欲，中世纪神秘主义的精神的志向与爱的热望，异教的回归和波吉亚兄妹的罪恶，无不表现得精美优雅，淋漓尽致。

This system is a self-designed and realized interactive animation software system.

这是一个全部由我们自己开发的动画系统。

In three-dimensional computer animation we can use software constraints to force all or some of the motion within arcs.

在三维立体电脑动画，我们可以使用软件的限制，迫使全部或部分的议案，内弧。

For a ghastly moment I thought he might be planning a soundtrack full of l960s pop hits — that black hole compounded of Cliff Richard, Paul Anka, Liberace, Lonnie Donegan — but Nick said no, he wanted to know what I and my schoolmates really listened to.

在一个极令人不快的时刻，我认为他正在计画一个全部是六十年代的流行音乐的电影配乐——由Cliff Richard、Paul Anka、Liberace和Lonnie Donegan的音乐混合而成的黑洞——但是Nick说不是的，他想要知道我和我的同学们实际上听什麽。

Results All patients were followed up in a short time without osteomyelitis or other syndrome except one The functions of knee joint and anklebone recover very well .

结果平均随访11个月，骨折固定稳定可靠，除1例骨折不愈合经植骨Ⅱ期愈合外全部愈合，愈合时间短，无骨髓炎、断钉等并发症，膝踝关节功能恢复良好。

However, the price cannot be represented all, the lever of the market is at the beginning of November fadein action, because the market is hot, businessman hasten benefit, the log that accelerated rosewood of Vietnam chrysanthemum pear, flocculus imports an amount, together with price is exorbitant, exceeded the purchasing power that buys the home, still have the factor such as the adjustment of the stock market, annatto price produced a few change in November.

然而，价格不能代表全部，市场的杠杆在十一月初渐显功能，因为市场热，商家趋利，加快了越南黄花梨、小叶紫檀的原木进口量，加之价格过高，超过了买家的购买力，还有股市的调节等因素，十一月红木价格产生了一些变化。

I do love my job. But it should never annex my life.

我热爱我的工作，但它不应该成为我生活的全部。

Your goal is the complete annihilation of your enemy.

你的目标是你的敌人被全部干掉。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。