全身关节炎

Objective: 1）Observe the feasibility of the model of egg protein induced leporid rheumatoid arthritis. 2）By pathology observation of pathological synovium, find out the transformation of AIA leporid arthral synovium after urea injection and the infection to local and general disease. 3）Find out if urea has obvious side-effect to arthral cartilage. 4）Mensurate the VEGF expression of synovium, investigate the effect of VEGF on rheumatoid arthritis and the effect of urea on VEGF expression.

研究目的：（1）观察鸡卵蛋白诱导性兔类风湿性关节炎模型实验方法的可行性；（2）通过病变滑膜组织病理学观察，了解注射尿素后AIA兔关节滑膜病理形态的变化；以及对局部及全身病情的影响；（3）观察尿素对关节软骨是否有明显毒副作用；（4）测定滑膜VEGF表达，初步探讨VEGF在RA病变发展中的作用及注射尿素对VEGF表达的影响。

Polyarthritis model was induced by Freund's complete adjuvant in rats. The edema degree of the inflamed paws general affection T lymphocyte proliferation function, IL-1 activity secreted by celiac macrophage, peroxide lipid and SOD-1 in serum were detected.

用弗氏完全佐剂造成大鼠多发性关节炎，观察足跖肿胀程度、全身病变、脾脏T淋巴细胞增殖功能、腹腔巨噬细胞白介素 1(IL-1)分泌活性、血清脂质过氧化和超氧化物歧化酶(SOD-1)活性。

TWHF is a celastraceae vine climber, and is a Chinese herb used to treat rheumatoid arthritis and systemic lupus erythematosus, and functions as an anti-inflammatory, immunosuppressor and antitumor.

是一种卫矛科的攀缘性藤本植物，可作为中草药，治疗类风湿性关节炎、全身红斑性狼疮，并有抗发炎、免疫抑制、抗肿瘤等幼纂A是具有开发潜力之中草药。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

The result showed: The positive rate in systemic juvenile rheumatoid arthritis was much higher than polyarticular and pauciarticular JRA, which was 59.3%,28.6%, 9.1% respectively.

结果表明：幼年类风湿关节炎病人全身型该抗体的阳性率要明显高于多关节型和少关节型，分别为59.3％，28.6％，9.1％。

Patients with polyarticular course JIA (19 females, three males; mean age 13.9 years; mean disease duration 6.3 years; 15 with polyarticular onset, seven with systemic onset, one with residual systemic activity; eight rheumatoid factor positive; eight with erosive disease) were treated with etanercept for up to 24 months.

22名多关节幼年型类风湿关节炎患者(19 例女性， 3例男性；平均年龄 13.9 年；平均病程 6.3 年； 15例现有多关节症状， 7例有全身症状， 1例有残余的全身症状； 8例RF阳性； 8例有骨关节侵蚀)使用etanercept治疗超过24 个月。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失