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Objective: To investigate immunostimulatory activity of CpG ODN against immunosuppression mice, aged mice, pregnant mice and their newly born mice; To screen a CpG ODN that its immunostimulatory activity against human cord blood lymphocytes is stronger than others; To observe immunostimulatory activity of CpG ODN against premature infants cord blood lymphocytes and to observe its cytolysis against Kse2 cells.

摘要目的:探讨CpG ODN对免疫抑制小鼠、老年鼠、孕鼠及其新生小鼠的免疫刺激作用;筛选对人脐血淋巴细胞免疫刺激作用较强的一种CpG ODN;观察其对早产儿脐血淋巴细胞的免疫刺激作用及刺激NK细胞对K_(562)细胞的杀伤活性,为开发适合人类新型疫苗佐剂奠定基础。

At present there is no POCT instrument using TRFIA technique at home and abroad, so the time-resolved fluorometer based on immunochromatography described in this paper is developed on the basis of time-resolved fluorometers and it has the advantages of both the immunochromatography and TRFIA.

针对目前国内外尚无采用时间分辨技术的POCT(Point-of-Care Testing)分析仪的现状,本论文将时间分辨荧光免疫分析和免疫层析两种技术的优点相结合,研制了一种基于免疫层析技术的时间分辨荧光免疫分析仪。

It is characterized by malignant unusual hyperplasia and soading of cells in medulla ossium and other tissues, which can damage the normal hemopoiesis function and the mechanism of blood coagulation fibrinolysis and immunology.

机体的免疫功能与肿瘤的发生和发展有密切关系,当宿主免疫功能与肿瘤的发生和发展有密切关系,当宿主免疫功能低下或受抑制时,肿瘤发病率增高,而在肿瘤进行性生长时,患者的免疫功能进一步受到抑制。

Although powerful immunosuppressant drugs such as CsA and FK506 can suppress rejection, their side effects such as hyperpiesia, hepatorenal toxicity, severe infection, malignant degeneration limit their long time usage. Nowadays the key method to avoid or alleviate these side effects is induction of immune tolerance or specific low immunoreaction state with simultaneous maintenance of immune response against other antigens (including anticancer, anti-infection and so on).

尽管CsA和FK506等强有力的免疫抑制剂己被应用,但由其所产生的肝肾毒性、严重感染和致肿瘤性等副作用仍然未能解决,因此造成宿主对移植抗原处于免疫耐受状态或低免疫反应状态,又不影响机体对其他抗原的正常免疫应答能力,是目前器官移植术后解决排斥反应的根本途径。

The neutralization antibody titres of pCIL2gD or pCIL6gD were about equal to that of inactivated vaccine group and were higher significantly than that of pcDD group.

在首免和加强免疫后,pCIL2gD或pCIL6gD免疫组的仔猪产生的中和抗体滴度均显著高于pcDD免疫组,达到全病毒灭活疫苗免疫组的抗体水平。

Objective To Investigate the immunologic syrup on the immunologic function of neutrophil in normal and immunosuppressed mice.

目的 探讨免疫口服液对正常小鼠和免疫抑制小鼠中性粒细胞免疫功能的影响。

The lumbar spinal cord in normal rat was immunohistochemically stained with ABC method using HAP1B antibody. Under light microscope, it was observed that HAP1 immunoreactants is mainly distributed in the pericaryon and neuropil in superficial lamella of the gray nucleus with little or no expression in other layers of the spinal horn. The substantia alba show no HAP1B immunoreactants.

对正常大鼠腰段脊髓进行HAP1B的ABC法免疫组织化学染色,光镜下观察显示,HAP1免疫反应产物主要分布在脊髓灰质背角浅层神经元胞体和神经毡内,灰质其他各层无或极少HAP1B表达,白质内未见明显HAP1B免疫反应产物。

Wistar rats were randomly divided into normal group, sham-operation group, 4 weeks diabetes mellitus model group (M4), 6 weeks diabetes mellitus model group (M6) and 8 weeks diabetes mellitus model group (M8). Behaviour was tested with Morris water maze and shuttle box test.

穿梭箱实验、Morris水迷宫实验检测大鼠认知行为学改变,免疫组织化学法、免疫印迹法、RT-PCR和酶联免疫吸附法检测BACE1;ELISA法检测Aβ在糖尿病大鼠脑组织中的表达,用图像分析仪测定吸光度值。

Adoptive immunotherapy is to sensitized lymphocytes, or the product of sensitized lymphocytes (such as transfer factor and immune RNA, etc.) lost to cellular immune function, to obtain anti-tumor immunity ...

过继免疫是把致敏淋巴细胞或致敏淋巴细胞的产物(例如转移因子和免疫核糖核酸等)输给细胞免疫功能低下者,使其获得抗肿瘤免疫力。。。。

ResultsIn the immune deficit mice ,1.33g/kg Naoshu capsule could enhance the phagocytic activity of monocytes, 0.67g/kg and 1.33g/kg Naoshu capsule could increase content of haemolysin antibody,and decrease footpad swelling induced by cyclophosphamide.

结果1.33g/kg脑舒胶囊能提高免疫低下小鼠单核巨噬细胞吞噬功能;0.67g/kg和1.33g/kg脑舒胶囊能增加免疫低下小鼠溶血素抗体生成,并拮抗环磷酰胺诱导的免疫低下小鼠足垫肿胀度减轻。

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