免疫抑制的

Most are chemotherapeutic agents, immunosuppressive medications, or cytotoxic treatments for malignant neoplasms or immunologically based conditions.

大多是为治疗恶性肿瘤或免疫系统疾病而使用的化疗药物、免疫抑制剂、细胞毒性药物。

Objective: To investigate the cellular signal transudation pathway of vascular smooth muscle cell proliferation and cytokins secretion stimulated by oxidized low density lipoprotein and insulin-like growth factor-1 (IGF-1) and the intervention effect of HMGcoA reductase inhibitor, atovastatin and immune supppressor, rapamycin.

目的：探讨氧化低密度脂蛋白，胰岛素样生长因子-1(IGF-1)促血管平滑肌细胞增殖及分泌功能改变的细胞内信号转导机制及三羟基三甲基戊二酰辅酶A抑制剂阿托伐他汀与免疫抑制剂雷帕霉素干预作用。

Objective: To investigate the cellular signal transudation pathway of vascular smooth muscle cell proliferation and cytokins secretion stimulated by oxidized low density lipoprotein and insulin-like growth factor-1(IGF-1) and the intervention effect of HMG-coA reductase inhibitor, atovastatin and immune supppressor .rapamycin.

目的：探讨氧化低密度脂蛋白，胰岛素样生长因子-1(IGF-1)促血管平滑肌细胞增殖及分泌功能改变的细胞内信号转导机制及三羟基三甲基戊二酰辅酶A抑制剂阿托伐他汀与免疫抑制剂雷帕霉素干预作用。

Results: 1. The value of all experimental indexes decreased significantly after heat stress, and reached the lowest at the time 2-8 hours after heat stress. This indicates that the immunity of the mice is damaged to the largest extent at 2-8 hours after heat stress. 2. L-arginine supplementation with appropriate dose could remit the acute atrophying of thymus and spleen tissue caused by heat stress. 3. After L-arginine supplementation with appropriate dose, the lymphocyte proliferation, the level of concentration of IL-2 and * expression of IL-2R raised in the group with room temperature; in the heat stress group the level of three indexs decrease significantly. Furthermore, the decrease of the group given 1 .Smglg.bw L-arginine is the smallest. This result indicates that the concentration of 1 .Smglg.bw L-arginine supplementation could remit the depressment of the immunity caused by heat stress. 4. The [Ca2~] in activated thymocytes of the group with L-arginine -2- supplementation is significantly higher than that of the group with water supplementation. This indicates that L-arginine supplementation could protect thymoeytes of mouse under heat stress. We also found that the fluorescence intensity of [Ca2~] in activated thymocytes of the group given 1 .Smglg.bw L-arginine is the highest.

结果：1、热应激后小鼠的各项免疫指标均有显著性下降，其中在2.8小时降到最低，提示在这个时间段小鼠的免疫功能受到最大损害；2、适量补充精氨酸有助于缓解热应激导致小鼠胸腺和脾脏的急性萎缩；3、常温组，补充适量精氨酸后小鼠淋巴细胞增殖活性、IL-2的浓度及IL-2R的表达均有显著性上升，而热应激后三指标均显著降低，其中在精氨酸给予浓度为1.5mg/g.bw时三指标的降低程度最少，提示该浓度可最大程度缓解热应激对小鼠免疫功能的抑制；4、补充精氨酸组的活化胸腺细胞［Ca~(2+)］较给水组有显著性上升，说明精氨酸对热应激小鼠胸腺细胞具有保护作用，并发现在精氨酸给予浓度为1.5mg/g.bw时活化胸腺细胞的胞浆钙离子荧光强度达到最大；5、热应激后小鼠血清NO的浓度均有不同程度的上升，补充精氨酸后血清NO上升更加明显，但并非随精氨酸给予浓度的增加而增加。

Supercharging the immune system while the immune suppressors are still at work is a little like revving a car engine without releasing the emergency brake: in both cases, you're not going anywhere.

如果在免疫抑制仍然在发挥作用的情况下增强人体免疫系统，这有点像一边踩油门一边踩刹车，无论怎么做，都得不到效果。

OBJECTIVE: To build an immunosuppressive mouse model, primarily screen and evaluate the immunotoxicity of medical heat vulcanizing silicone rubber.

目的：建立免疫抑制毒性小鼠模型，并针对医用热硫化硅橡胶的免疫毒性进行初筛和评价。

For metabolites of strain SIPI-800, three active compounds were found, named as SIPI-800-1, 2 and 3 respectively, moreover SIPI-800-1 was new compound showing immunosuppressant activity and moderate anti- anaerobic activity; 2 and 3 were isoflavones with estrogenic activity, attracting activity to fungal zoospores, inhibiting alcohol dehydrogenase and aldehyde dehydrogenase I activities.

对SIPI-800菌株的代谢产物研究，分离出3个活性化合物，分别命名为：SIPI-800-1、2和3，其中1化合物为文献没有报道的新化合物，具有免疫抑制活性（1ug/ml浓度抑制NK细胞88.9%的活性）和弱的抗厌氧菌活性；2和3为异黄酮化合物，分别为Daidzein和Genisten的7甲基化衍生物，具有雌激素活性、强吸引真菌游动孢子、抑制乙醇或醛脱氢酶等活性。

Using a model of the muscle pouch of bone graft, the effects of the systemic and local administration of IL-4 plus IL-10 on bone xenograft rejection were studied through the determination of lymphocyte responses from the mixed lymphocyte culture , subsets of lymphocyte, cytokines and histology in 1, 2, 4, and 6 weeks after implantation.

分别于术后1、2、4、6周取材，进行淋巴细胞刺激增殖实验、淋巴细胞亚群分析、细胞因子检测及组织学检查，了解移植免疫特点，并观察经腹腔和局部注射IL-4和IL-10后产生的免疫抑制作用。

Methods: Twenty four BALB/c mice were equally randomized into 2 groups: immunocompetent group and immunocompromised group.

24只BALB/c小鼠，随机均分为免疫抑制组（腹腔注射200 mg/kg的环磷酰胺）和未抑制组。

According to correlative literatures, the diagnosis and treatment of bronchiolitis obliterans syndrome in three patients with hematological malignancies after allo-HSCT were analyzed. The function of haematopoiesis re-established successfully. The acute graft versus host disease did not occur in these patients except one patient occurred grade Ⅱ aGVHD, and the chronic graft versus host disease occurred in the 5th, 6th and 6th months after allo-HSCT respectively, but the cGVHD was recrudescent after treatment. The bronchiolitis obliterans syndrome occurred in the 9th, 7th and 11th months after allo-HSCT respectively, and they received the treatment of immunosuppressive, immune human serum globulin, azithromycin and to breathe in β2 receptor agonist and budesonide.

结合相关文献，对3例恶性血液病患者异基因造血干细胞移植后发生闭塞性细支气管炎综合征的临床特点和诊断治疗进行分析。3例患者移植后造血功能均顺利重建，2例未发生急性移植物抗宿主病，1例发生II度急性移植物抗宿主病；3例患者分别于移植后5，6，6个月发生广泛型慢性移植物抗宿主病，经治疗后病情仍有反复；3例患者分别于移植后9，7，11个月发生闭塞性细支气管炎综合征，给予免疫抑制剂、静脉免疫球蛋白、阿奇霉素及局部使用β2受体激动剂及布地奈德吸入治疗，2例在治疗4周后病情有所改善，另1例病情无改善。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。