免疫抑制的

Mel coule promote the proliferation of PBL and prohibite the apoptosis of PBL from type 2 DM patients, and its effect varied with its concentration; Mel took its greatest influence at the pharmacological concentration, probably due to Mel could regulate the function of immune system and have effect of antioxidation.

Mel有促进2型DM患者外周血淋巴细胞的增殖反应并有效抑制其凋亡的作用，可能与Mel的免疫调节和抗氧化作用有关，为临床应用Mel作为2型DM的辅助用药奠定基础；4。

METHODS:After the treatment of TRAIL or LPS at different doses,we tested the nuclear translocation of NF-κB by cell immunohistochemical staining and electrophoretic mobility shift assay,and evaluated the level of IκB by RT-PCR under pyrrolidine dithiocarbamatetreatment.

当不同浓度的TRAIL和LPS作用于细胞后，我们通过细胞免疫组化染色和凝胶电泳迁移试验来检测NF-κB核转位的情况。并通过RT-PCR的方法粗略评定二硫代氨基甲酸吡咯烷对抑制蛋白IκB的影响。

It was neither the crossed immune respons,resulted from being infected with Rinderpest virus or Febris catarrhalis infectiosa canun virus which were closely relative to morbillous viruw,nor was interfered with by the non-specificity agglutinin and the there was the possibility that the production or the substance was resulted from being infected with morbillous virus.

在本地猪群血液中所检出的麻疹血凝抑制抗体样物质，并非由于猪感染与麻疹病毒有近缘关系的牛瘟病毒或犬瘟病毒而出现的一种交叉免疫反应，也不是非特异性凝集素的干扰，对猪感染麻疹病毒所致的可能性尚找不出理由排除。

The ELISA titre was 1:2000.By cell fusion, 46 hybridoma cell lines were screened,and 10 lines were cloned with limited dilution method.16 lines secreting anti-bFGF monoclonal antibody were been developed, and 2 lines targeted fusion protein. Sensitive ELISA and dot-ELISA for bFGF was developed with this mAb. The detection limit of them were 0.1 ng/well and 0.5 ng/well. The expression level of anti-bFGF mAb by different rebuilt engineering cells were identified by western blot and to direct rebuild recombiment engineering cell. The dose and character of anti-bFGF mAb inhibiting bFGF biology activity were searched by 3T3 cell line. Searching 20 tissue of liver cancer, liver cancer cell lines and general tissue of liver, finding bFGF were highly expressed in tissues of liver cancer and liver cancer cell lines. Affinity chromatography purifying bFGF was set up by mAb binging CNBr-pepharose 4B, and the purification was 95%. We found that the titer of anti-bFGF antibody was very high in serum of neuropathic amyotrophia.

应用细胞融合制备46株杂交瘤，对其中10株进行克隆化，获得bFGF特异单抗16株，2株针对融合蛋白；应用该单抗建立了0.1ng/孔灵敏度的ELISA，0.5ng/孔敏度的斑点ELISA；用Western-blotting鉴别了经改造不同工程菌蛋白表达，指导重组工程菌改造；用3T3细胞培养研究了单抗抑制bFGF生物学活性的剂量和特点；合作研究了20例肝癌、肝癌细胞株和正常肝组织，发现前者bFGF高表达；应用单抗偶联CNBr-sepharose 4B建立了小量免疫亲和层析纯化bFGF，纯度达到95%；发现神经性肌萎缩患者血清中含有高滴度的bFGF抗体，已有10多家单位引用单抗或进行合作。

The most convincing evidence of this view came from Aotus monkey trial in which immunization of the monkeys with native PtMSP 1 isolated from cultured falciparum malaria parasites provided partial to complete protection against the challenge of homologious strain.

用纯化的MSP1天然蛋白免疫的夜猴能部分或完全保护后来同种疟原虫的攻击感染。MSP1特异单抗或多抗能在体外有效抑制疟原虫的生长。

Crocin could inhibit the growth of BALB/c xenograft tumor. The morphology changes of cell apoptosis were observed. Bcl-2, Cyclin D1 and survivin expressions determined by immunohistochemical staining were down-regulated after treatment with Bax expression up-regulated.

Crocin对人膀胱癌裸鼠移植瘤的生长具有抑制作用，电镜观察可见细胞凋亡的形态学改变，免疫组化结果显示，经Crocin处理后Bcl-2， survivin，Cyclin D1的表达下调，而Bax的表达上调。

In order to reach this goal,the primary basic research work is to clone,evaluate and analyse the function of the genes that support or impact the development of malaria parasites in the mosquito vecter and the study on the mechanisms of innative immune defence responses against Plasmodium infection.

于上世纪九十年代，WHO提出了基因操纵蚊媒的新策略，而寻找支持或抑制疟原虫在蚊体内发育的相关基因，克隆、鉴定及分析其功能，以及研究按蚊抗疟原虫感染的先天性免疫反应机制是实现这一策略的重要前提。

It is a fungus parasitic on the larvae of Lepidopteral . A broad spectrum of its pharmacological functions in hepatic function, renal function, cardiovascular function, immunomodulation, endocrine and steroid system, nervous system, and anticancer activity has been reported.

许多研究报告指出其药理作用的范围，包括了肝、肾、心血管功能，并可影响神经及内分泌系统，且对於免疫力的调控及抑制癌症有相当的功效；其中认为最值得探讨的就是调控免疫系统以对抗癌症发生的能力。

Results After screening, 59 subtracted library clones were isolated which were specific for strain VIB72, and the DNA sequences of these clones were determined. Seventeen fragments showed high homology to the genes of known functions in other bacteria. This includes soluble lytic murein transglycosylase, mobilization protein, transposase (IS66), resistance-related protein (metallo-beta-lactamase and acetyltransferase family), toxin protein (DT-201 and alveicin A immunity protein), ATP-dependent endonuclease of OLD family like protein, SocE and GTP-binding protein HflX (high frequency of lysogenization).

通过对差减文库筛选，分离到59个对菌株VIB72的克隆，并对这些克隆的DNA序列进行了测定。17个基因片断与其它细菌的已知功能的基因有较高的同源性，其中包括可溶性溶胞壁质转糖基酶、转移蛋白MobA和MobC、转座子IS66、抑制相关蛋白（金属β-内酰胺酶和乙酰转移酶家族）、毒素蛋白（DT-201和alveicin A免疫蛋白）、与OLD 家族相似的ATP依赖性核酸内切酶以及SocE 和GTP结合蛋白HflX。

In vitro, their effects are also dramatically different from one another with only beta androstenetriol potentiating the cellular response by increasing lymphocyte activation and counteracting hydrocortisone immune-suppressive activity.

在体外，它们的作用也是彼此明显不同的，唯有雄甾烯三醇对淋巴细胞有强有力的细胞应答，并且抵消氢化考地松抑制免疫的活动。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。