免疫抑制的

Objective: To investigate immunostimulatory activity of CpG ODN against immunosuppression mice, aged mice, pregnant mice and their newly born mice; To screen a CpG ODN that its immunostimulatory activity against human cord blood lymphocytes is stronger than others; To observe immunostimulatory activity of CpG ODN against premature infants cord blood lymphocytes and to observe its cytolysis against Kse2 cells.

摘要目的：探讨CpG ODN对免疫抑制小鼠、老年鼠、孕鼠及其新生小鼠的免疫刺激作用；筛选对人脐血淋巴细胞免疫刺激作用较强的一种CpG ODN；观察其对早产儿脐血淋巴细胞的免疫刺激作用及刺激NK细胞对K_(562)细胞的杀伤活性，为开发适合人类新型疫苗佐剂奠定基础。

However, large amount of immunosuppressants can cause not only the side-effects, such as hyperpiesia and hepatorenal toxity, but also severe infection and malignant carcinoma, especially in a long run.

然而，长期使用免疫抑制剂除了会引起免疫抑制剂本身的毒副作用（诸如升高血压、肝肾毒性等不良反应）外，也可引起严重感染、恶性肿瘤的发生，从而影响器官移植的成功率和受者的长期存活率。

Although powerful immunosuppressant drugs such as CsA and FK506 can suppress rejection, their side effects such as hyperpiesia, hepatorenal toxicity, severe infection, malignant degeneration limit their long time usage. Nowadays the key method to avoid or alleviate these side effects is induction of immune tolerance or specific low immunoreaction state with simultaneous maintenance of immune response against other antigens (including anticancer, anti-infection and so on).

尽管CsA和FK506等强有力的免疫抑制剂己被应用，但由其所产生的肝肾毒性、严重感染和致肿瘤性等副作用仍然未能解决，因此造成宿主对移植抗原处于免疫耐受状态或低免疫反应状态，又不影响机体对其他抗原的正常免疫应答能力，是目前器官移植术后解决排斥反应的根本途径。

The second patient, a 29-year-old male, suffered from a seriously disfiguring facial tumor in the middle and lower parts of his face, classified as a neurofibroma. On January 21, 2007, he underwent the transplantation surgery at the Henri Mondor Hospital of Creteil, France, and was subsequently administered drugs to suppress immune rejection.

第二个病例是一个 29岁的男性患者，她的脸中部和下部患有一种严重的毁容性肿瘤——神经纤维瘤。2007年1月21日，他在法国Creteil的Henri Mondor医院接受了面部移植手术，随后接受了旨在抑制免疫排斥的免疫抑制剂治疗。

The immune level tested in different time after injection with ginkgolic acids in sensitization mode showed that the expression of CD3〓 and CD4〓T lymphocytes increased, but CD8〓 was restrained, while the B lymphocytes was also increased. The results suggested that sensitivity was approved and T lymphocytes proliferation was induced, which strength cell immunity responsion, at the same time B lymphocytes was differentiated to IgE antibody-producing cells when contacted with ginkgolic acids as allergen.

大鼠经致敏方式接触银杏酸后，在不同时间的细胞免疫水平与体液免疫水平的研究结果表明，大鼠CD3〓及CD4〓T淋巴细胞的表达增加，而CD8〓T淋巴细胞的表达受到明显抑制，同时参与体液免疫的B淋巴细胞百分率呈增高趋势，提示银杏酸可能作为变应原使机体敏感性增强，诱导T细胞分裂增殖，增强细胞免疫应答，同时促进B细胞增殖分化成IgE抗体产生细胞。

Pioneering work by Cohen and coworkers about T cell vaccination in the experimental autoimmune disease, has showed that the establishment of immune response against T cell vaccine, such as anti-idiotype T cells or anti -idiotype antibody, by the way of the upregulation of immune networks, and subsequently functional depression of autoimmune to self-antigen were made by vaccining mice or rate with the attenuated autoreactive T cells .

从研究TCV在防治自身免疫性疾病中的作用机制表明，人为的TCV免疫，建立了拮抗T细胞的免疫应答，使免疫网络产生上调作用，抑制了原有的或即将出现的相关T细胞的功能，由此推测，是否能够把同种反应性T细胞作为TCV，来建立抗同种免疫反应的内环境，诱导抗原特异性的同种免疫耐受或免疫低反应性。

The experiments may contribute not only to investigating the mechanism of interaction between ldiotype and anti -idiotype T cells by which immune network are up-regulated, but also to analysing the suppressive effect of anti -idiotypic T cell or antibodies against the antigens on the activated T cells in the allo-responsiveness.

本课题选用小鼠耳后心肌移植模型，用同种抗原特异的活化T淋巴细胞免疫同系小鼠的方法，诱导免疫小鼠同种心肌移植物存活时间的延长，以此探讨免疫网络中独特型-抗独特型相互作用机理，着重分析在同种抗原诱导的免疫应答中，抗独特型T细胞和抗活化T淋巴细胞抗原抗体对同种免疫反应的抑制作用。

When stratifying by immunosuppressive treatment, patients on methylprednisolone therapy had fewer CD14+CD16+ monocytes than patients not receiving MP.

对免疫抑制治疗方案进行分组，采用包含甲强龙的免疫抑制方案的患者CD14+CD16+少于那些不采用甲强龙的患者。

General condition, wound area, and histological characters were observed, as well as the proliferation of T and B lymphocyte by MTT assay, phagocytosis of Mφ in abdominal cavity by neural red assay were investigated respectively.

结果如下： 1 整体试验 1.1 免疫抑制复合皮肤伤口模型的复制-阳虚型愈合迟缓性皮肤伤口以氢化考的松处理小鼠造成免疫抑制状态，用特制打孔器在鼠背打一圆孔，采取全厚皮切除术，复制ISW模型。

Objective To Investigate the immunologic syrup on the immunologic function of neutrophil in normal and immunosuppressed mice.

目的 探讨免疫口服液对正常小鼠和免疫抑制小鼠中性粒细胞免疫功能的影响。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。