免疫抑制的

The effect of the specific inhibitor cibacron blue of GSTs and antiparasitic drugs albendazole, praziquantel and artesunate on the activities of recombinant GSTM, GST1 and GST2 was evaluated.

研究目的解析三个胞质GSTs的基因结构及其特点，克隆三个胞质GSTs基因，鉴定原核表达的重组GSTs的免疫反应性、免疫原性、催化活性及其免疫定位和抑制剂、常用抗寄生虫药对催化活性的影响。

BACKGROUND: It has been indicated that neuro-immuno-modulation peptide,α-melanophore-stimulating hormone, can play an effective role in anti-inflammation, antibiosis, defervescence and immunological regulation through inhibiting the release of proinflammatory factor, improving the vigor of lymphocyte and other ways, so that it has a good prospect in the prevention and treatment of systemic inflammatory response syndrome.

背景：研究表明，神经免疫调节肽α-黑素细胞刺激素(α-melanophorestimulating hormone，α-MSH)可通过抑制促炎因子释放、改善淋巴细胞活力等途径发挥其抗炎、抗菌、退热和免疫调节作用，在防治全身炎性反应综合征中可能有良好的应用前景。

Methods The stablishment of lymphoblast cell lines was by EBV-immortalization and subtyping of the cell lines by cell fusion, mytomycin C inhibition analysis and/or immunoprecipitation and Westemn blot.

方法将我国3例FA患者外周血细胞用EB病毒活化法建立原始B-淋巴细胞系，采用丝裂霉素生长抑制试验和细胞融合后MMC抑制试验的互补试验进行分型；利用单克隆抗体免疫沉淀法和Western blot法进行分型。

At pre-operation, post-operation 6 h, 3 d and 7 d detect the leave of plasm prethrombotic state molecular marker tissue factor, tissue factor pass inhibitory, thrombus precursor protein, plasminogen activator inhibitory-1(PAI-1), P-Selectin, Thrombin-Antithrombin complexes, D-dimer with ELISA, transmission immunity nephelometer. Results Malignant tumor patients, the levels of plasma TF, TpP, D-D in 6 h and 3 d of post-operation rose to peak value.

分别于术前、术后6 h3、d和7 d用ELISA、透射免疫比浊法检测其血浆血栓前状态分子标志物D-二聚体(D-dimer， D-D)、血栓前体蛋白(thrombus precursor protein， TpP)、凝血酶抗凝血酶复合物(thrombin-antithrombin complexes， TAT)、组织因子(tissue factor， TF)、P选择素(P-Selectin， P-S)、组织因子途径抑制物(tissue factor pass inhibitory， TFPI)、纤溶酶原激活物抑制物1(plasminogen activator inhibitory-1， PAI-1)的水平。

The blood IgG and IgA level of new soldiers is significantly lower than that of control,But the IgM level is higher than that of control.Conclusion It suggest that old soldiers' paratroop stress is normal,the high stress can be lessen by training.

新兵在跳伞应激状态下免疫功能受抑制，但老兵免疫能力没有下降，某些免疫指标还有增高，表明老兵跳伞应激的反应是适度的，严重的跳伞应激可通过多次的训练而得以减轻。

Allabove indicated that the more antitumor ability of PELs was not theirmount,perhaps,but their quality.

以上这些说明微环境中一定水平IL-2的存在能使肿瘤的细胞免疫应答速度加快，免疫细胞获得杀伤能力所需时间短并伤百分率高，从而使在这种微环境中肿瘤细胞的生长明显受到抑制，同时也说明mIL-2〓诱导的PEL抗肿瘤能力，并非是通过免疫细胞数量上的增加来实现。

More recent evidence suggests that antimicrobial peptides are effective adjuvants, are synergistic with other immune effectors, initiate the adaptive response, support wound healing, induce or modulate of chemokine and cytokine production, alterate of gene expression in host cells, and inhibit of proinflammatory responses of host cells.

近来，越来越多的证据表明抗菌肽是有效的免疫辅助因子，能够与其他的众多免疫效应子协同作用，从而起始适应性免疫，促进伤口愈合，抑制前炎症反应以及诱导和调节细胞因子和趋化因子的产生。

Epidermal growth factor has an important positively influence on cytotrophoblast invasion, while Transform growth factor-β〓 has a negative influence.

如表皮生长因子为一种强的促有丝分裂因子，对滋养细胞侵蚀有促进作用；而转化生长因子-β为免疫细胞抑制因子，对滋养细胞侵蚀有抑制作用。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

With the methods of molecular biology, in situ hybridization, immunohistochemistry, immunohistochemistry, radioimmunodetection, Electrophysiology, we have studied the depressant effect for hypermyotonia of experimental cerebral infarction rat and its the gamma-aminobutyric acid receptor mechanisms first time when we simulated the GB 34 with electric acupuncture.

本课题以大鼠实验性脑梗死动物模型为研究对象，采用分子生物学原位杂交技术、免疫组织化学染色法、放射免疫检测技术、神经电生理记录方法，首次较系统研究了电针阳陵泉对脑卒中动物肢体肌张力增高的抑制作用及其GABA受体机制。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。