免疫抑制的

The results show that: This tablet can decrease the rat"s footpad swell induced by Freud"s, inhibit the permeability of the blood capillary in inflammatory joint and decrease the 11-2 level in serum while increasing the rat"s body weight,(2) It can lower the rat"s temperature and the permeability of the blood capillary in inflammatory joint induced by collagen and inhibit the delayed type hypersensitivity,It can lower the stickiness of full blood and the accumulation of erythrocyte obviously inblood stasis model rats,lt can inhibit the formation of hemolysin and decrease the index of carbon granule clearance in mice, It can lower the permeability of celiac blood capillary and inhibit the granulomatous hyperplasia by sc cotton ,It can inhibit the pain induced by acetic acid and raise the pain threshold value of heat stimulation.

结果表明：关络通片能明显降低佐剂性关节炎大鼠左右足趾肿胀度，降低大鼠炎症关节的通透性，抑制其IL-2含量，对大鼠体重增长缓慢有一定的改善作用；能改善Ⅱ型胶原诱导性关节炎大鼠的表征指标及炎症关节的通透性，对其迟发型超敏反应有一定的抑制作用；对血瘀模型大鼠，能显著性降低其全血粘度、血浆粘度、红细胞压积；能抑制小鼠的溶血素抗体生成，抑制小鼠网状内皮系统的吞噬能力，具有一定的抑制机体免疫功能的作用，能抑制小鼠腹腔毛细血管通透性增高，抑制大鼠棉球肉芽组织增生，具有一定的抗炎作用；能抑制小鼠醋酸扭体反应、提高小鼠热板痛阈值，具有一定的镇痛作用。

In the aspect of clinical therapy, hormone andimmunosuppressant including cortin, cell toxin, biological preparation are themost of the medicine commonly used in the western medicine to treat NS at theprecent. Due to the biggist toxin and side effect of incretion andimmunosuppressantrelatively looger using drug, and quite quabtitative suffers arenot sensitivity to the therapy.

在临床治疗方面，激素类、免疫抑制剂仍然是目前西药治疗肾病综合征的常用药物，但激素和免疫抑制剂存在较大的毒副作用且用药时间较长。

Objective To explore the ageand gender of mice, the optimal dose of the dexamethasone phosphate and the optimal time of immunosuppression in the mice model applied for C.parvum oocyst infectivity and reproduce.

目的 探索适合隐孢子虫卵囊传代和扩增模型小鼠的性别、日龄、免疫抑制时间和免疫抑制剂地塞米松磷酸钠的最佳剂量。

Results In the aspect of oocyst intensity discharged from mice, femal BABL/C mice were more than the male, the 50 day-old mice(26 g～28 g) were more than the 25 and 75 day-old, mice in 15 mg/L group were more than those in the and mice infected after immunosuppressed for 3 days were more than those infected after immunosuppressed for –6,-3,0,6,9 days.

结果 雌性小鼠排卵囊强度均较同日龄雄性小鼠大，而不同日龄小鼠中又以50日龄(26 g～28g)小鼠排卵囊量最多；各剂量组小鼠中，15 mg/L组排卵囊强度较其他各组大，10 mg/L组小鼠次之；免疫抑制时间各组中，免疫抑制3天后感染的小鼠排卵囊强度较其他组大。

The results indicated that avilamycin has significant effects on the non-specific immunity of Cyprinus carpio.

对鲤投喂适宜浓度(4mg／kg—8mg／kg)的阿维拉霉素，短期内有一定的免疫促进作用，投喂较长时间后会发生免疫抑制；对鲤使用高浓度的阿维拉霉素(≥16mg／kg)时，会迅速发生免疫抑制。

As an immunomodulator NO may play a role like a double-edged sword since it expresses both in immuonchalleged and immunosspresed states. 2. After received external stimulus the morphology of ependyma of SFO could be changed and varied with time course, particularly its cellular apoptosis do occur and earlier than the ordinary areas of the brain. 3. Astrocytes in SFO could express cFos protein induced by LPS, suggesting the cells may maintain homeostasis in the brain in a longer period and modulate immune state of the brain. 4. As a CVO, SFO may sense changes of blood-bearing immunosignals earlier and instantly response to them, thus as one of windows of the brain SFO do take part in immunomodulation within the brain.

通过我们的实验结果我们可以得出这样一些初步的结论：1、一氧化氮作为免疫调质参与了机体免疫，它既能在免疫激发状态下又可在免疫抑制状态下进行表达提示，NO在脑内免疫调节中的作用可能是双向的。2、穹窿下器的室管膜形态在接受外界刺激后，随着时间的变化而不同，扫描电镜下的凋亡形态虽需进一步证实，但室管膜细胞确实发生了凋亡，并且穹窿下器发生的较早。3、穹窿下器内的星形胶质细胞在给予大肠杆菌后确实可以表达c-fos蛋白，并可能通过自身的激活来较长时间的维持体液的动态平衡，调节脑内免疫状态。4、穹窿下器作为感受性室周器官之一，能够较早的感受血携免疫信息的改变并及时作出反应，可能作为外周免疫信息进入脑内的窗口之一来参与脑的免疫调节。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

"Recent studies on the autoimmune origin of vitiligo also emphasize the probable implication of the immunosuppressive action of UV therapy in the repigmentation of vitiliginous plaques," the authors note."acrolimus, a new topical immunosuppressive drug developed for the treatment of atopic dermatitis, has shown some interesting results in treating vitiligo in 2 prospective studies."

研究人员指出，最近对於白斑自体免疫来源的实验，也强调了UV疗法的免疫抑制作用对於白斑再色素化可能的应用；Tacrolimus，一种新的局部免疫抑制药物，被开发用於治疗异位性皮肤炎，已经被两项前瞻性试验受瞩目的结果证实可以治疗白斑。

The key problem for limb , skin or other composite tissues transplantation is to control posttransplantation rejection , which encumbers long term functional survival of transplanted organ and tissues .

作为皮肤复合组织移植的受者，术后出现排斥反应的几率很高，排斥反应发生的程度和频率将直接影响移植组织能否长期存活及功能能否及时恢复，而免疫抑制剂的个体化用药是否合理又直接影响术后免疫排斥反应发生的频率和程度，因此为受者&量体裁衣&制定免疫抑制剂术后个体化给药方案，是保证移植组织或器官有功能性的长期存活的关键因素之一。

MNSFP was a previously identified novel implantation-related factor that needed to be further investigated in our lab, and is a lymphokine produced by suppressor T cell.

MNSFD是本实验室正在研究的另一个新发现的着床相关因子，它是一种由抑制性T细胞合成的具有非特异性免疫抑制作用的淋巴因子，因其能抑制IL-4的分泌和Th2细胞的产生，所以推测其可能与母胎间免疫耐受的形成有关，但有待于研究证实。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。