免疫性

BioMarin Pharmaceutical Inc.(NASDAQ: BMRN) has acquired Huxley Pharmaceuticals, Inc. Huxley Pharmaceuticals, Inc. has rights to a proprietary for of 3,4-diaminopyridine, amifampridine phosphate, for the autoimmune disease Lambert Eaton Myasthenic Syndrome.

拜玛林制药公司（NASDAQ：BMRN）已经收购了赫胥黎制药公司赫胥黎制药公司已3，4 -氨基吡啶的专有权利，amifampridine磷酸盐为自体免疫性疾病朗伯Eaton肌无力综合征。

In this review data on the use of rituximab is presented from 92 studies involving 1197 patients with the following diseases: systemic lupus erythematosus, idiopathic thrombocytopenic purpura, anti-neutrophil cytoplasmic antibody associated vasculitis, Grave's disease, autoimmune hemolytic anemia, pemphigus vulgaris, hemophilia A, cold agglutinin disease, Sjogren's syndrome, graft vs. host disease, thrombotic thrombocytopenic purpura, cryoglobulinemia, IgM mediated neuropathy, multiple sclerosis, neuromyelitis optica, idiopathic membranous nephropathy, dermatomyositis, and opsoclonus myoclonus.

本综述资料总结了92项共1197例患者应用利妥昔的研究，包括系统性红斑狼疮、特发性血栓性血小板减少性紫癜，抗中性粒细胞抗体相关性血管炎、甲状腺功能亢进、自身免疫性溶血性贫血、寻常型天疱疮、甲型血友病、冷凝集素病、干燥综合征、移植抗宿主疾病、血栓性血小板减少性紫癜、IgM介导性神经病、多发性硬化、视神经脊髓炎、特发性膜性肾病、皮肌炎和眼肌阵挛性肌阵挛。

The applications of the immunotherapies in the autoimmune neuropathies （including demyelinating peripheral neuropathy, antibody mediated diseases at myoneural junction, inflammatory disease, stiff-man syndrome and multiple sclerosis） were evaluated.

静脉注射丙种球蛋白、血浆交换和激素治疗神经系统自身免疫性疾病的疗效是肯定的，但是对于具体的疾病选择联合应用还是单独使用、激素的使用剂量和用药时机尚无明确的定论。

Objective To assess the clinical effects of infliximab in experimental immune myositis.

目的 观察英夫利昔对实验性免疫性肌炎的治疗效果。

Objective To study the effects of IFN-γ,TNF-α,IL-10and IL-12on the B7mRNA and protein expression of lymphocyte in experimental autoimmune myositis.

目的 探讨B7在实验性自身免疫性肌炎发病中的作用及γ干扰素、肿瘤坏死因子α、白细胞介素-10(IL-10)、IL-12对其的影响。

Protophase empirical study confirmed that SLT can treat nephritis model of immunity and mesenterium hyperplasy, and can obviously lighten interstitial fibrosis of nephric tubule induced by Adriamycin.

前期实验研究证实，SLT 对大鼠免疫性系膜增生性肾炎模型有治疗作用，能明显减轻阿霉素所诱导的肾小管间质纤维化。

Investigation showed aquaporin-4 played an important role in humoral-mediated immunologic mechanism of neuromyelitis optica.Meanwhile,NMO revealed an autoimmune channel disease,and the study on the immunopathogenesis of NMO was ushered into a new stage.

目前研究发现AQP4还参与视神经脊髓炎的体液免疫机制，揭示了NMO是一种自身免疫性通道病，这一发现使NMO的免疫和病理学研究进入了一个新的阶段。

Thyroid associated ophthalmopathy is an organ special autoimmune disorder, of which the pathogenesis is still unclear.

摘要甲状腺相关眼病是一种器官特异性自身免疫性疾病，确切的发病机制尚不清楚。

Thyroid-associated Ophthalmopathy is the most frequent autoimmune disease in the orbit disease, which is always related to thyroid disease.

甲状腺相关性眼病是眼眶病中最常见的疾病，大部分与甲状腺疾病相关，属于自身免疫性疾病。

Based on relative literatures,this part has included five resesearch aspects as below.1 Fifteen compounds were isolated and purified by extraction,column chromatography,and their structures were determined on the basis of spectral analysis: acteoside(Ⅰ-1),isoacteoside(Ⅰ-2),crenatoside(Ⅰ-3),cistanoside F(Ⅰ-4),sinapoyl-4-O-β-D-glucoside(Ⅰ-5),adenosine(Ⅰ-6),β-siterol(Ⅰ-7),oleanic acid(Ⅰ-8), succinic acid(Ⅰ-9),caffeic acid(Ⅰ-10),protocatechuic aldehyde(Ⅰ-11),p-hydro xybenzyl alcohol(Ⅰ-12),β-daucosterol(Ⅰ-13),D-galacitol(Ⅰ-14),D-mannitol(Ⅰ-15).Ⅰ-4～15 were obtained from this plant for the first time,andⅠ-6,7,9,and 13 were isolated from Orobanche genus for the first time.2 The scavenging test of DPPH showed that most compounds have comparative antioxidant activity as L-ascorbic acid and part of them show better activity such as the O.coerulescens extract and phenylethanoid glycosides.Acteoside showed potent free radical scavenging effects with a median inhibition concentration of 25.6μg/ml.3 The anti-HBV activities of acteoside,isoacteoside and crenatoside were measured,and all of them showed suppressive activity on the expression of HBsAg and HBeAg in the HepG2.2.15 cell line.

本论文在文献调研基础上对紫花列当化学成分及生物活性进行了研究，并从免疫抗病毒角度探讨紫花列当中特征性成分类叶升麻苷的肝保护作用及其机制。1采用大孔树脂、硅胶和Sephadex LH-20等色谱技术对紫花列当进行系统的植物化学研究，从中分离得到19个化合物，利用UV和NMR等波谱手段及理化性质鉴定了其中的15个化合物，分别为类叶升麻苷(Ⅰ-1)、异类叶升麻苷(Ⅰ-2)、crenatoside(Ⅰ-3)、cistanoside F(Ⅰ-4)、sinapoyl-4-O-β-D-glucoside(Ⅰ-5)、腺苷(Ⅰ-6)、β-谷甾醇(Ⅰ-7)、齐墩果酸(Ⅰ-8)、琥珀酸(Ⅰ-9)、咖啡酸(Ⅰ-10)、原儿茶醛(Ⅰ-11)、对羟甲基苯甲酸(Ⅰ-12)、β-胡萝卜苷(Ⅰ-13)、D-半乳糖醇(Ⅰ-14)和甘露醇(Ⅰ-15除化合物Ⅰ-1、Ⅰ-2和Ⅰ-3外，其余化合物均为首次从该植物中分离得到。2)通过大孔树脂富集该药材有效部位苯乙醇总苷，并采用HPLC测得其所含特征性成分类叶升麻苷的含量可达80%以上。3DPPH自由基清除试验显示紫花列当提取物及其所含的苯乙醇苷类化合物均具有较好的抗氧化能力，其清除DPPH自由基能力接近于抗坏血酸。4采用卡介苗整体致敏、脂多糖离体攻击构建大鼠原代肝细胞免疫性损伤模型，在体外观察类叶升麻苷的保肝作用。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。