免疫发生

"Might disturbances in the microbial balance of human intestines trigger an immune system response that leads to metabolic disease?" Marden and Schilder asked.

Marden和Schilder提出了这样一个问题："有没有可能人类肠道中的微生物种群失衡触发免疫系统发生反应而导致代谢性疾病的发生呢？"

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin，Caspase3 及MTA1的表达情况。结果（1）结肠癌组织中Livin的阳性表达率显著高于癌旁组织，且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（2）结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织，且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。（3）结肠癌组织中MTA1的阳性表达率显著高于癌旁组织，且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（4）Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论（1）Livin在结肠癌组织中过表达，它可能是促进结肠癌发生的重要因素之一。（2）Caspase3蛋白在结肠癌组织中表达被抑制而降低，且与Livin的表达呈负相关。因此，抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。（3）MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

Objective To study the relationship between DNA fragments in ENV gene of SIVmac and viral replicating ability. Methods Reciprocal recombinants were constructed by replacing the clonable DNA fragments of ENV region of the nonpathogenic SIVmac142 clone with the pathogenic SIVmac 239 clone.

猴免疫缺陷病毒(simian immunodeficiency viruses SIV)是一组在致病性和毒力方面具有多样性的灵长类动物病毒，其中，SIVmac239克隆感染的猴表现为与人类AIDS相似的疾病，称之为致病株，而SIVmac142克隆仅引起猴发生病毒血症，不发生临床综合征，称之为非致病株〔1〕。

Change of T-lymˉphocyte subsets may play an important role in DU,and immune function of the patients with DU is nearly associated with the pathophsiology of DU.

T淋巴细胞亚群的变化可能在DU的发生、发展中发挥了重要作用，DU的发生、发展及预后与机体免疫功能状态密切相关。

Some skin cancers are doing PUVA, arsenic occurs after treatment, or coated with coal tar, pine oil distillation system after the application of immunosuppressive drugs, and some had no apparent incentive.

有的 皮肤癌是在进行PUVA、砷剂治疗后发生或在外涂煤焦油、松馏油和系统应用免疫抑制剂后发生的，有的则无明显诱因。

The cloning and identification of these genes are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis.

发现并研究精子发育不同阶段表达的基因及其调控因子，深入研究它们在精子发生中的作用，将有助于阐明精子发生的机理，为探索不育机理和寻找免疫避孕的新途径奠定理论基础。

The cloning and identification of these genes are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis. Such study can also provide foundation and cues to investigate the mechanism of infertility and immunocontraception.

发现并研究精子发育不同阶段表达的基因及其调控因子，深入研究它们在精子发生中的作用，将有助于阐明精子发生的机理，为探索不育机理和寻找免疫避孕的新途径奠定理论基础。

After observation of the clinic symptoms, chicks were killed on day 7 and day 14, then weighed, measured the index of the immune organs and the antibody level of Newcastle disease. The experiment has observed the pathologic lesions and histopathological changes and evaluated the effect of sulfaquinoxaline on chicks.

结果］雏鸡饮用0.2%磺胺喹恶啉连用1周是安全的，连用2周发生轻度中毒的表现；雏鸡饮用0.5%磺胺喹恶啉很快发生中毒表现，磺胺喹恶啉中毒可使雏鸡出现严重临床症状，机体免建机能下降，免疫器官发育受阻，抗体水平降低，肌肉出血，肝、肾等实质器官变性种胀。

Repeated corneal perforation occurred in nine eyes, with primary diseases of herpes simplex keratitis (HSK; four eyes), Mooren ulcer, necrotizing keratitis and scleratitis, bacterial keratitis, and alkali burn. Corneal grafts perforated in 31 eyes, resulting from recurrent HSK, implant autoproteolysis, bacterial infections, recurrent Mooren ulcer, immunologic rejection, trauma, and fungal recurrence.

本研究中有9只眼发生了反复的角膜穿孔，其原发疾病分别为单疱病毒性角膜炎（HSK，4只眼），蚕食性角膜溃疡（2只眼），坏死性角巩膜炎（1只眼），细菌性角膜炎（1只眼）和碱烧伤（1只眼）。31只眼发生了角膜植片穿孔，分别由单疱病毒性角膜炎复发（8只眼），角膜植片自溶（7只眼），细菌感染（6只眼），蚕食性角膜溃疡复发（4只眼），免疫排斥反应（3只眼），外伤（2只眼）和真菌复发（1只眼）引起。

Objective To investigate the expression and significance of basophilic fibroblast growth factor during hepatocarcinigenesis in the rats.

目的 探讨碱性成纤维细胞生长因子(basic fibroblast growth factor，bFGF)在肝癌发生过程中的表达及意义方法采用免疫组织化学ABC法对二乙基亚硝胺诱发大鼠肝癌发生过程中碱性成纤维细胞生长因子表达情况进行观察。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。