免疫原性

Only a reaction mice without immunogenicity of substances, called hapten, such as penicillin, sulfa, etc..

只具有反应原性而没有免疫原性的物质，叫做半抗原，如青霉素、磺胺等。

The new chimeric infectious DNA clone and its derived, a virulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position.

所述新型嵌合的传染性DNA克隆及其衍生的有毒力的嵌合病毒是用非致病性PCV1构建的，其中，致病性PCV2的免疫原性ORF基因取代了非致病性PCV1的基因，优选是在相同的位置上取代。

In order to overcome the shortcomings of acellular dermal matrix used as tissue engineering scaffold material, such as bad permeability, low degradation speed, and strong immunogenicity, a new type of collagen scaffold was prepared by applying various chemical, biological and physical comprehensive methods to deal with pigskin. The microstructure of the scaffold was observed under photomicroscope and scanning electron microscopy, and the in vitro degradation time, permeability, tensile-strength, porosity, shrinkage temperature were tested.

为了克服猪脱细胞真皮基质作为组织工程支架材料渗透性差、降解速度过慢、免疫原性较强等缺点，采用多种化学、生物与物理综合方法处理猪皮制备了一种新型天然胶原支架材料，通过光学显微镜、扫描电镜观察以及体外降解时间、透水汽性、拉伸强度、孔隙率、收缩温度等的测定，对其性能进行了研究。

The results showed that the purified serum can recognize MUC1 protein ..proliferation assays of T-cells from spleen of Balb/C inoculated with the positive phages showed that T-cells were markely proliferated in absence of adjuvant during immunization , which demenstrated that phage might be a proper vector for the immunization.

为证实模拟抗原的免疫原性，进一步用展示MUC1抗原模拟表位的噬菌体阳性克隆免疫小鼠，3次免疫小鼠后，血清(1：1000)中能检测到较强的MUC1抗体阳性；以最大OD450值之纯化血清做为一抗行蛋白印迹分析，结果显示：纯化血清可识别MUC1蛋白；小鼠脾脏淋巴细胞增殖率检测结果表明：噬菌体展示肽表位可在无佐剂存在情况下，大大促进小鼠的脾淋巴细胞的增殖，证明噬菌体是一较好的生物载体。

Core protein, which is very conservative, can induce high level of humoral and cellular immunity. For these years, Core antigen was expressed in E.coli successively. But E.coli is uncapable of managing gene expression and protein procession like eukaryotic cell.

HCV核心蛋白高度保守且有很强的免疫原性，可诱发高水平的特异性体液免疫及细胞免疫，是HCV诊断试剂中必不可少的组分之一。

Humulus scandens grass pollen major allergen DNA vaccine pcDNA3.1-LC2 has been successfully constructed. It can be expressed in mice, produces humulus scandens grass pollen allergen specific antibody and has a good immunogenicity.

成功的构建了葎草花粉主要变应原核酸疫苗pcDNA3.1-LC2，pcDNA3.1-LC2可在小鼠体内表达，并能产生葎草花粉变应原特异性抗体，具有良好的免疫原性。

Pallidum-antibody with indirected-ELISA based on the fusion protein. Zealand rabbits were immunized with the fusion protein, antibodies to anti-Gpd in sera were detected with indirected ELISA.

同时用纯化的Gpd重组蛋白免疫新西兰兔，间接ELISA方法检测免疫兔血清中Gpd多克隆抗体的效价，对Gpd重组蛋白的免疫原性进行分析。

Of them 25 cases of oral cancer (G1-2) were randomly divided into trail and control group . The remained 11 cases of nasopharyngeal and maxillary sinus cancer (NPC-MSC, mainly G3-4) were attributed to a third group (1st course: sBRM, then 2nd course: IAC). The order of drug-use of sBRM is: pre-immunomodulation of the reactivity of patient low-dose CTX and PolyI∶C, then in- juring tumor and thereby modulation of its immunogeneity (DDP-PYM regimen , thereafter, reaction enhancement modu- lation [low-dose rhuIL-2, Cimetidine and Indomethacin ] . All drugs, except for CTX, PolyI∶C and Indo, were fractionally delivered in a manner of continously infution in 8-10 hours via a retaining intra-external carotid artery catheter CAVAFIX 335 SPLITTOCAN G14, B.

将其中25例晚期口腔高、中分化鳞癌病人随机分为实验治疗（12例）和对照治疗（13例）两组，实验组采用sBRM疗法，具体用药为：先用小剂量环磷酰胺和聚肌胞对机体反应性作预调变，然后用低剂量DDP-PYM化疗杀伤&致创&癌细胞，使其免疫原性增强并借之诱导肿瘤浸润淋巴细胞，化疗结束后续用小剂量rhuIL-2激活和扩增TIL，特别是其中的T细胞，并借助小剂量西咪替丁、消炎痛调节机体以原发灶为中心的癌受创相关反应。

There are postulations that some positions of GP is the structural basis for some important biologic features of rabies virus, neurotropic, pathogenicity and antigenicity.

狂犬病毒GP基因上某些位点推测是狂犬病毒一些重要生物学特性，如：组织嗜性、致病性和免疫原性等的结构基础，因此这些部位的变异有可能导致这些特性的改变。

A multi-epitope antigen gene pcx was assembled by five highly conserved B-and/or T-cell epitopes, which were selected from C (1-16aa, 132-141aa), E1 (126-135aa), NS3 (139-147aa) and NS5B (768-775aa) protein, as well as a T-cell epitope of tetanus toxin, which was added to enhance T-cell immunity.

针对HCV的高度变异性及免疫特点，在HCV基因产物中优选了5个具有良好免疫原性的高度保守B／T细胞表位，组合成一个多表位抗原基因pcx，这些表位分别来自核心蛋白(1～16aa，132～141aa)，E1(126～135aa)，NS3(139～147aa)及NS5B(768～775aa)，以及破伤风毒素的T细胞表位用以增强T细胞免疫。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。