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AIM: To study the effects of paecilomyces cicadidae total polysaccharides on the immune function and free radical scavenging of tissue, in immunosuppressed rats.

目的:观察蝉拟青霉总多糖对免疫抑制大鼠组织器官免疫功能调节和自由基代谢的影响,探讨其对免疫抑制大鼠组织器官的免疫调节和抗衰老作用。

AIM: To study the effects of paecilomyces cicadidae total polysaccharides on the immune function and free radical scavenging of tissues in immunosuppressed rats.

目的:观察蝉拟青霉总多糖对免疫抑制大鼠组织器官免疫功能调节和自由基代谢的影响,探讨其对免疫抑制大鼠组织器官的免疫调节和抗衰老作用。

The slow and constant HBV infection has distinct connection with the identification, responsion and endurance of HBV antigen by human immune systems.

HBV感染的慢性化和持续感染与免疫系统对HBV抗原的识别、应答和耐受明显相关,因此HBV特异性免疫应答对决定慢性乙肝病毒感染者的病程、病理和转归有极重要的意义,是什么因素导致了机体免疫系统一系列的免疫异常进而导致对HBV感染的持续无应答状态和疾病的慢性化过程?

The immune level tested in different time after injection with ginkgolic acids in sensitization mode showed that the expression of CD3〓 and CD4〓T lymphocytes increased, but CD8〓 was restrained, while the B lymphocytes was also increased. The results suggested that sensitivity was approved and T lymphocytes proliferation was induced, which strength cell immunity responsion, at the same time B lymphocytes was differentiated to IgE antibody-producing cells when contacted with ginkgolic acids as allergen.

大鼠经致敏方式接触银杏酸后,在不同时间的细胞免疫水平与体液免疫水平的研究结果表明,大鼠CD3〓及CD4〓T淋巴细胞的表达增加,而CD8〓T淋巴细胞的表达受到明显抑制,同时参与体液免疫的B淋巴细胞百分率呈增高趋势,提示银杏酸可能作为变应原使机体敏感性增强,诱导T细胞分裂增殖,增强细胞免疫应答,同时促进B细胞增殖分化成IgE抗体产生细胞。

This paper was to observe the revaccination effect of domestic yeast-derived recombinant hepatitis B vaccine to children who were born to HBsAg and HBeAg negative mothers and had been immunized with full course of blood-derived hepatitis B vaccine 4 years ago at their birth.

为了观察用国产重组酵母乙型肝炎疫苗,对已经血源乙肝疫苗初免的儿童再免疫的效果,以乙肝表面抗原和乙肝e抗原阴性母亲所生的、出生时全程接种血源乙肝疫苗后已4年的儿童为对象,用5μg重组酵母乙肝疫苗进行再免疫,同时用10μg血源乙肝疫苗再免疫作对照,观察2种疫苗再免疫后1、12、24个月乙肝表面抗体反应。

The treated group was revaccinated with 5μg YRHBV while the control group with 10μg blood-derived HB vaccine, their anti-HBs response was determined 1,12,24 months after revaccination.

结果显示:用5μg重组酵母乙肝疫苗进行再免疫能取得良好的抗-HBs应答,不论再免疫前抗-HBs水平高低,再免疫后能呈现免疫回忆反应。

ELISA showed that antibody responses induced by propolis vaccine were faster than that of oil-emulsion vaccines and aluminum hydroxide vaccines;antibody responses induced by oil-emulsion vaccines were longer in duration than that of propolis vaccines and aluminum hydroxide vaccines;the maximum antibody responses induced by oil-emulsion vaccines and propolis vaccines were higher than that of aluminum hydroxide vaccines;Antibody levels were all significantly boosted by revaccination of these vaccines and in addition to this,oil-emulsion vaccines showed longer antibody duration.

这七种疫苗在抗体产生速度方面以蜂胶苗较快,而油剂苗和铝胶苗免疫后抗体上升速度较慢;在抗体水平的维持能力方面,油剂苗较蜂胶苗和铝胶苗更强;在产生最高抗体水平方面,油剂苗和蜂胶苗能力相当且较铝胶苗为高;在加强免疫的效果方面,这些疫苗二次免疫所产生的抗体水平均较一次免疫更高,蜂胶苗和铝胶苗在第93天时的二免抗体水平已降至同一免相当,但此时油剂苗有着较一免更高的二免抗体水平。

Autoimmunity hypothesis of schizophrenia figures schizophrene has a certain degree of immunological functional disturbance,Hypothalmu- pituitary- adrenal axis can produceimmunosuppression. Hydrocortisone,the production of HPA axis,serve as important medium of immunosuppression, so we presume that hydrocortisone possibly induce immunological dysfunction of schizophrene.

精神分裂症的自身免疫假说认为精神分裂症患者存在一定程度的免疫功能低下,而下丘脑-垂体-肾上腺轴功能紊乱被认为是引起免疫抑制作用的主要机制之一,其中皮质醇是免疫抑制作用的重要介质,因此我们推测精神分裂症患者可能存在有皮质醇含量增高有关。

With rarefied the albumen after is vaccine of oily emulsion of immune former preparation immune egg chicken, the result makes clear, CCK albumen can cause immune reaction inside gallinaceous body, tenability of antibody of the CCK in serum of chicken of the egg after strengthening immunity and yolk is in higher level.

以纯化后的蛋白为免疫原制备油乳剂疫苗免疫蛋鸡,结果表明,CCK蛋白可在鸡体内引起免疫反应,加强免疫后蛋鸡血清和卵黄中CCK抗体可维持在较高水平。

Serum immunoglobulin of Amur sturgeon Acipenser schrenckii, Chinese sturgeon Acipenser sinesis and Huso sturgeon Huso dauricus which were healthy and unimmuned, was first time respectively purified by using saturation ammonium sulfate precipitation followed by Sephadex G-200 gel column chromatography. Molecular weight and partial characterization of Ig and heavy chain and light chain of Ig were measured by polyacrylamide gel electrophoresis, SDS polyacrylamide gel electrophoresis, Western blotting and Ouchterlony method.

采用饱和硫酸氨分步沉淀和Sephadex G-200凝胶层析的方法,首次分别纯化制备了健康非免疫状态下中华鲟、史氏鲟和达氏鳇的血清免疫球蛋白,并采用聚丙烯酰胺凝胶电泳、SDS-聚丙烯酰胺凝胶电泳、蛋白免疫印迹及免疫琼扩实验等方法对其Ig及Ig亚单位的分子量和部分特性进行了分析。

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