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In recent years the merged images from immunofluresence microscopy showed that NCAMP-1 and NCCRP-1 are coexpressed on NCC membranes and may participate in innate immunity against bacteria by granule exocytosis during inflammatory responses in teleosts. These membrane proteins are evolutively conserved from teleostean fish to mammalian.

近年来免疫荧光显微镜技术表明NCAMP-1和NCCRP-1两种受体蛋白均表达于NCC膜上,并且这种免疫细胞从鱼类到哺乳动物上的进化是保守的,这些膜蛋白在鱼类炎症反应期可能通过颗粒胞吐途径参与抗菌的先天性免疫

Then we transfected transitorily the recombinant of green fluorescent protein gene and middle molecular weight neurofilament cDNA into wide type N2a (N2a/wt) and N2a/tau40 to observe the effect of tau accumulation on GFP-NFM fusion protein transport in cellular processes in living cells. At last we used an apoptotic inducer, camptothecin (an inhibitor of topoisomerase-1) to treat N2a/wt and N2a/tau40 cell lines, and compared their apoptotic response.

主要结果如下:一、tau蛋白过度表达和聚积对细胞形态的影响:倒置显微镜下观察两种细胞的形态,发现N2a/wt细胞的突起多而长,而N2a/tau40细胞胞体变圆,突起明显缩短;免疫印迹结果显示转染了tau40的细胞内tau的免疫反应约增加14倍,免疫荧光结果显示N2a/tau40细胞胞体内呈现出较强的红色荧光,tau主要分布在核周和突起起始部分的胞质内,而N2a/wt细胞内的荧光很弱。

Objective To screen the protective antigen of G.intestinalis and set the foundation for immune reseach of vaccine. Methods The trophozoite antigens were obtained with in vitro culture system of Giardia lamblia Stile. After further separation, purification and activity verification, the antigens were used to immunize the BALB/C mice divided into different groups,then indexes associated with immunity were determined. Through challenge infection, the most protective antigenic component of G.intestinalis were selected based on its anti-infection ability.

目的 筛选蓝氏贾第鞭毛虫的保护性抗原,免疫疫苗的研制奠定基础方法利用已建立的蓝氏贾第鞭毛虫滋养体体外培养系统,获取滋养体抗原,并进步分离、纯化、活性鉴定;然后分组免疫小鼠,检测相关免疫指标;再行攻击感染试验,视其抗感染能力,筛选出保护性强的抗原组分。

Core protein, which is very conservative, can induce high level of humoral and cellular immunity. For these years, Core antigen was expressed in E.coli successively. But E.coli is uncapable of managing gene expression and protein procession like eukaryotic cell.

HCV核心蛋白高度保守且有很强的免疫原性,可诱发高水平的特异性体液免疫及细胞免疫,是HCV诊断试剂中必不可少的组分之一。

The challenge of achieving improved monitoring of all transplant patients may allow tailoring of immunosupression in a proportion of recipients thereby increasing the opportunities for the induction of specific unresponsiveness to donor alloantigens in the future.

未来的挑战是,对移植患者的免疫系统进行良好的监测,应用个体化的免疫抑制方案,从而增加诱导针对供体同种抗原特异性免疫无反应性的机会。

The clinic of nursing care have documented that large dose injection of gamma globulin can prevent and cure the complication of aeteria coronaria , large dose intravenous drip of gamma globulin,2g/kg,intravenous drip slowly in 8 to 12 hours, gamma globulin has two therapeutic actions including immune vicariousness and immune accommodation. It can improve the patients' IgG level of blood quickly after intravenous drip of gamma globulin.

护理临床已证明大剂量丙种球蛋白注射,可有效防治川崎病时冠状动脉并发症,大剂量丙种球蛋白静脉滴注,2g/kg,于8-12h缓慢输入,丙种球蛋白具有免疫替代和免疫调节双重治疗作用,经静脉输入后,能迅速提高患儿血液中的免疫球蛋白

Previous studies have shown thatlymphocytes from patients with malig-nant disease, when encountering abasic protein fraction isolated fromhuman glioma, display a slowingeffect to macrophage electrophoreticmobility.

对用人脑胶质瘤碱性蛋白免疫的38只豚鼠和23只对照组豚鼠进行了巨噬细胞电泳试验,其巨噬细胞电泳减缓率免疫组为6.13±1.06%,对照组为0.96±0.90%;经统计学处理,两组间有显著区别,表明GBP能激发豚鼠的细胞免疫反应性。

In addition, the volume of milk in the immune substances, such as immunoglobulins, immune cells, lysozyme activity, as well as AKGs (ie alkoxy glycerol, breast milk is the milk AKGs content 10 times) and so on, did not smell and cattle colostrum to enhance your baby's resistance to a similar role in human milk.

此外,人乳中的在量免疫物质,像免疫球蛋白、免疫活性细胞溶菌酶,以及AKGs(即烷氧基甘油,母乳中的AKGs含量是牛奶的10倍)等,未闻及牛初乳对增强孩子的抵抗力有类似人奶的作用。

Through active immunization of Inhibin antige n from porcine seminal plasma and super ovulation of allochthonous purified FSH, the effect of IB active immunization on cow was studied and its mechanism was al so further ascertained by examination of relative hormone concentrations in seru m at different physiological periold.12 Hostein cows and 12 Xiza young cows of 3 -5 years old (postpartum 50 d and above),were selected and divided into the exp e rimental group and control group randomly according to the estrum order.

张志胜 ,田树军,王志刚,桑润滋用猪精液抑制素抗原主动免疫供体母牛,结合外源纯化FSH超排处理,观察了抑制素主动免疫对牛超排效果的影响,并通过检测不同生理时期血液中相关生殖激素的水平,探讨了抑制素免疫影响牛超排效果的机制。

More recent evidence suggests that antimicrobial peptides are effective adjuvants, are synergistic with other immune effectors, initiate the adaptive response, support wound healing, induce or modulate of chemokine and cytokine production, alterate of gene expression in host cells, and inhibit of proinflammatory responses of host cells.

近来,越来越多的证据表明抗菌肽是有效的免疫辅助因子,能够与其他的众多免疫效应子协同作用,从而起始适应性免疫,促进伤口愈合,抑制前炎症反应以及诱导和调节细胞因子和趋化因子的产生。

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