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This paper reviewed the principle of electrokinetic in situ remediation of contaminated groundwater and soils by electrokinetics and its newest advances in research and applications, expatiated on the advantages of this technology over other technologies, pointed out the obstacles to overcome in using this technology, and discussed the possibilities in full-scale commercial applications.

综述了电动力学修复技术原理及近几年来其在重金属修复中的最新研究进展,阐述了电动力学修复技术相对于其它修复技术的优势,并指出了电动修复技术中需要克服的技术障碍,探讨了其大规模商业应用的可行性。

Analysis of nuclear extracts of human cells has indicated a similar excision repair mechanism for nick-directed mismatch correction in higher cells, and several reconstituted systems that rely on purified human proteins have been described, such as hMutSα、hMutSβ、hMutLα. Recently, scientists discovered that nickel could be inhibitors of DNA repair. Nickel can greatly enhance the mutagenicity and genotoxicity of compounds in cigarette by inhibiting the nucleotide excision repair pathway in human cells. We have confirmed that nickel could inhibit MMR of E. coli and human and presumed that nickel inhibited repair before MutH incision of the MMR in E. coli. However, there is no evidence of mechanism of nickel inhibiting MMR in human cells.

镍是存在於香菸中的微量金属,近年来有学者发现镍是DNA修复反应的抑制剂,长期抽烟的人会容易因为香菸中化合物攻击DNA而引起突变,进而引起肺癌,而镍会抑制核苷酸移除修复系统(nucleotide excision repair;NER),所以使得体内的DNA损伤无法修复;过去实验室已经证实大肠杆菌的核酸配对错误修复系统会受到镍等重金属的抑制,并且推测出镍的抑制反应是抑制在修复反应的上游nicking的步骤;另外,也证实了人类的核酸配对错误修复系统也会受到镍的抑制,然而还没研究证实会抑制在核酸配对错误修复反应的哪个步骤。

In this study the composites were applied to repair the rabbits'mandibular defects and implanted at the surface as onlay grafts that was fixed with dental implants. The ability of the composites repairing maxillofacial defects was evaluated with general observation, radiological and histological examination and compared with autogenous bone and coral.

本研究通过观察rhBMP-2、胶原、珊瑚复合骨修复兔下颌骨缺损,加高狗下颌骨骨面及与牙种植体结合,并与新鲜自体骨和珊瑚的修复作用比较,(1)应用复合骨修复兔下颌骨缺损,1、2、3个月取材,(2)将复合骨植于狗下颌骨体部颊侧骨膜下,采用钛种植体固定,1.5、3个月取材,通过体视及测量,X线片,组织学等观测指标,分析rhBMP-2、胶原、珊瑚复合骨修复骨缺损特点和体内降解特点。

Results Followed-up for 25~37 months (average 27.5 months), the fisrt signs of reinnerveation of suprascapular nerve appeared at 5~12 months,average 9.94±3.26 months,that of axillary nerve appeared at 9~15months, average12.60±3.08 months;The results in patients with suprascapular nerve as recipient(upper partial 57.08±21.16°, total 40.71±14.27°) were significantly better than that in patients with axillary nerve as recipient(upper partial 31.25±20.97°, total 18.75±7.50°). And the muscular function in upper, middle and lower portions of trapezius are affected due to nerve transfer.

结果 随访25~37个月(平均27.5个月),来院随访18例;副神经移位修复肩胛上神经术后功能恢复征象最早出现在5~12个月,平均9.94±3.26个月,修复腋神经最早出现在9~15个月,平均12.60±3.08个月;修复肩胛上神经肩外展恢复结果(上臂丛神经损伤57.08±21.16°,全臂丛损伤40.71±14.27°)优于修复腋神经的恢复结果(上臂丛神经损伤31.25±20.97°,全臂丛损伤18.75±7.50°),P.05;副神经移位后斜方肌各部功能丧失明显。

RESULTS: During 10 - 12 weeks, in cuntrol group: The defect area was repaired by white and soft tissue that had no resistance to press. The repaired tissue was still lower than the surrounding articular surface with clear boundary. By histological observation, it was found that the defect was repaired by the mechanism similar to inflammatory reaction and the defect is ultimately filled by the hyperplasia of hyaline degenerative fibrous tissues. In filling group: the defect was repaired by semi-transparent, smooth, textured tissues with polish that had resistance to press as well as elasticity. The repaired tissue was almost similar to the shape of the surrounding cartilage,difficult to be distinguished. After histological observation, it was found that there was no inflammatory reaction, but active hyperplasia of inner bonetissue and cartilage tissues; a lot of osteoid tissues and trabeculation were found. Newlborn cartilage was fused with surrounding cartilage tissue and connected with surrounding tissues.

结果:10~12周,对照组:缺损区由白色、质软、按压无阻抗的组织修复,修复组织仍低于周围关节面,边界仍清晰可辨,组织学以类似炎症反应的机制修复缺损,最终以透明变性的纤维组织的增生来填补缺损部位;填充组:缺损区由半透明状、质韧光滑有光泽,按压有阻抗并有弹性的组织修复,修复组织与周围软骨外形上已基本相似,不易区分,组织学未见有炎症反应的过程,内骨组织和软骨组织增生活跃,并可见大量类骨组织和骨小梁形成,新生软骨和周围软骨组织融合,并与周围组织连接。

objective to introduce a method for repair of defects of alae nasi.methods transplantation of whole or partial free auricle composite tissue was designed in reconstruction of alae nasi.partial auricle composite tissue transplantation was used in 14 patients,the area of the graft was 1.0cm×1.5cm~1.9cm×2.5cm.whole auricle composite tissue transplantation was used in 6 patients,the area of the graft was 0.5cm×0.5cm~0.8cm×1.2cm.results all grafts survived.the grafts were dark red or light red in color,there were no blisters on them.follow-up of more than six months showed good results.conclusion in many methods for repair of defects of alae nasi,this method is simple,the appearance of alae nasi is good after operation and there is no new scar on face.

目的 修复鼻翼缺损。方法采用全层或部分耳廓复合组织游离移植的方法修复鼻翼缺损20例,其中以鼻翼残存瘢痕组织翻转作衬里,然后进行部分耳廓复合组织游离移植14例,移植物面积最小1.0cm×1.5cm,最大1.9cm×2.5cm;利用耳廓复合组织全层嵌入游离移植修复鼻翼缺损者6例,移植物面积最小0.5cm×0.5cm,最大0.8cm×1.2cm。结果 20例移植组织全部成活。色泽呈暗红至淡红不等,无水泡。随访半年移植物色泽与鼻组织基本近似,供区隐蔽。结论在诸多鼻翼缺损修复方法中,该方法简便易行、术后鼻翼外形好,面部显著部位不增加新的瘢痕,有独到优越性。

Methods 30 cases of nasal soft tissue de fects were reconstructed by different kinds of local flaps according to modified Burget′s nasal subunit. The Rintala flaps were used above the lowest level of low eyelids; at the area between low eyelids and the alar groove, the dorsal def ects were covered by ax-like local flaps and defects on side wall were reconstru cted by flaps rotated from the contralateral wall covered by skin graft; when it was below the highest level of alar groove, nasolabial flaps with subdermal ped ical were applied to nasal tip defection, and nasolabial local flaps to alar def ects, axial nasodorsum flaps supplied by the lateral nasal artery to defects inv olving columellae.

结合Burget鼻部美学分区,将其再分为三个区域,根据分区选用局部或邻位皮瓣修复鼻部各区软组织缺损30例(鼻根部以Rintala鼻额部局部皮瓣推进3例;鼻中段的鼻背部行双侧斧状局部皮瓣旋转3例;鼻侧壁行对侧壁局部皮瓣转移,供区植皮4例;鼻端部以鼻唇沟皮下蒂岛状瓣转移修复鼻尖部7例;鼻唇沟局部皮瓣旋转修复鼻翼部7例;鼻背轴型皮瓣旋转修复鼻小柱6例)。

In group A, the left musculocutaneous nerve was transected to make the model of biceps brachii denervation and anastomosed to its proximal end 6 weeks later; In group B, the musculocutaneous nerve was transected and the distal end was coapted to the purely motor medial pectoral nerve immediately and the musculocutaneous nerve was separated from the medial pectoral nerve, and reanastomosed to its proximal end 6 weeks later.

随机分为两组( n =8):肌皮神经延期修复组,单纯剪断左侧肌皮神经,造成肱二头肌失神经支配模型,6 周后行肌皮神经修复;神经移位寄养二期肌皮神经修复组,剪断左侧肌皮神经后即刻将胸内侧神经分支的近端移位寄养于肌皮神经的远端,6 周后结束寄养关系行二期神经修复术。

In this paper, the purpose, intension, application approach and long term potential of restoration heat treatment technique is analyzed in detail.

具体分析了修复热处理的技术内涵及应用途径,并对修复热处理的目的及内容进行了概述;重点讨论了材料失效机理和作为修复热处理基本原理的材料自愈合和自修复机理,并对修复热处理的基本方法和应用进行了简单介绍。

There are three suggestions are further proposed by the researcher: investigating the amount of Chinese rare book, their damaged types, and the existing book restoration resources within the country, devising a standard operation for recording the process of Chinese rare book restoration, and improving the education and training of Chinese rare book conservators.

最后,根据研究者在研究过程中对古籍修复作业的观察与了解,加上技术知识保存的研究分析,提出对古籍修复作业及其技术知识保存的建议,包括调查国内古籍数量、损伤情形及现有古籍修复相关资源、撰写古籍修复作业记录与积极培养古籍修复人才。

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