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While the β-catenin homologus Aardvark of Dictyostelium is absent, adherent junctions are lost. Aar also has a function in cell signaling and regulates expression of pre-spore gene.

盘基网柄菌β-连环蛋白同源物Aardvark的缺乏使细胞间失去粘著连接,Apr也有信号转导功能,调控了前抱子细胞基因的表达。

These results suggest that inositol 1, 3, 4-trisphosphate 5/6-kinase or its analogs may be involved in the osmotic stress response in Arabidopsis in stress signaling pathways dependent on and/or independent of abscisic acid.

这些结果表明,编码1,3,4-三磷酸肌醇5/6-激酶类似物的拟南芥基因家族的不同成员可能参与了依赖于ABA和不依赖于ABA的胁迫信号传递途径。

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用,PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化,从而减少脂质的异位沉积,进一步改善损伤的胰岛素信号转导通路,逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体;脂肪酸代谢;胰岛素抵抗

It is postulated that IP induces the release of endogenous protective molecules that interact with cognate receptors to activate PLC through mediation of the chincough virus sensitive proteins. PLC hydrolyzes membrane phospholipid and produces diacylglyccerol,that,by working together with calcium hydronium,translocates PKC from cytoplasm to cell membrane and activates PKC.

推测缺血预处理细胞保护作用机制是:缺血预处理引起内源性保护物质释放,作用于细胞膜上的相应受体,通过百日咳病毒敏感性G蛋白的介导而激活磷脂酶,磷脂酶水解膜磷脂,产生二酰基甘油(diacylglyccerol,DAG),DAG和Ca2+协同作用于PKC,使其从胞浆转位到细胞膜并且被活化,PKC在膜上使底物蛋白磷酸化,引发一系列相关信号转导通路的激活,调控保护性基因的表达,从而提高细胞对缺血再灌注损伤的耐受性。

A bar code business card printing and membership card making substrate cohniiand there must be enough to make the colour fastness to numerous bar code scanning, still keep a certain contrast value, obtain reliable input signal.

条形码制卡和会员卡制作承印物必须具有足够的着色牢度以使条形码经多次扫描阅读后,仍保持一定的对比度值,取得可靠的输入信号。

PIAS proteins play roles mainly through two mechanisms: acting as SUMO E3 ligases to promote modifications of some transcriptional factors and cofactors, especially sumoylation, and to regulate their transcriptional activation; acting as structural proteins to offer platforms for protein-protein interactions and to promote the abstraction and recruitment of other regulators in the cellular signal pathway complexes or gene transcriptional complexes, companied by the subnuclear location of target proteins.

PIAS蛋白的调控机制主要有两种:一种是通过其自身所具有的SUMO(small ubiquitin-related modifiers)E3连接酶活性,促进对一些转录因子、转录辅因子的化学修饰,尤其是SUMO化修饰,从而调控它们的转录活性;另一种是作为构架蛋白,为蛋白质之间的相互作用提供平台,促进细胞信号通路复合物或基因转录复合物中其它调节蛋白的去除和募集,并涉及到靶蛋白的亚核定位。

NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.

通过研究,我们提出了初步的NodD操纵子激活模型:第一,四聚体是NodD蛋白的功能单位,它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子;第二,小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体,在我们的模型中,NodD四聚体缩小其V形主体的弯折角,进而缩短其DNA结合功能域的间距;第三,小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用,NodD的构象改变由蛋白质经其双铆钉位点传递给DNA;第四,只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物;第五,不排除NodD与RNA聚合酶可能有直接的相互接触位点,不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物,但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。

The process of the invention envisages using the resulting signal for controlling the application of a deposit-controlling composition.

本发明的方法可以利用所产生的信号控制沉积物控制用的组合物的施加。

Theradar signal,usually in the form of a repetitive train of short pulses,is generated by a transmitter and radiated into space by an Bed / Night Stand or targets intercept and reradiate a portion of the radar signal;asmall amount returns in the direction of the radar and is collected by the antenna.

雷达信号(其形式通常为重复的短脉冲序列)由发射机产生,通过天线发射,反射物拦截并反射部分雷达信号,其中一小部分向雷达方向反射回来,被天线接收。

The very low natural IRSL and GLSL signal levels of about 80-100 photo counts per second, corresponding equivalent dose of less than 1Gy, were presented for most modern samples, and imply that the IRSL and GLSL signal zeroing could be reached during deposition for most of loess and water-laid sediments in North China.

华北地区大多数现代沉积物细颗粒组分的天然IRSL和GLSL信号水平很低,约80-100光子计数/秒,相对应的等效剂量值小于1Gy。这可能表明,华北地区大多数黄土及水沉积物的IRSL和GLSL计时器在沉积过程中可能已基本&回零&。细颗粒IRSL和GLSL的光晒退实验结果也说明这一点。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。

You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?