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Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果:酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间,给药剂量为80μg/kg/d时疗效最显著,达到69.24%,在20μg/kg/d-80μg/kg/d剂量范围内生命延长率为50-70%,给药剂量与荷瘤鼠生存时间呈现一定量效关系;酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长,给药剂量为160μg/kg/d时疗效最显著,抑制率为44.03%,并且在40-320μg/kg/d剂量范围内抑制率为25-50%,给药剂量与肿瘤抑制率呈现一定量效关系;酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用,在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显,其中浓度为100μg/ml时抑制率达19.36%;酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤:体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与效应细胞对照组相比有显著性差异(P<0.05)杀伤率分别达到35.58%、61.2%;体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P 。05),杀伤率分别达到21.39%、47.63%;裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强,与生理盐水对照组相比有显著性差异(P.05),最高杀伤率分别达到32.86%、73.07%;酪丝亮肤能增强单核巨噬细胞系统的吞噬功能,吞噬指数与生理盐水组比较有显著性差异(P.05);酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与效应细胞对照组相比有显著性差异(P.05);酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO,与生理盐水对照组相比有显著性差异(P.05);酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO,IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰,酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能,而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

Base on the statistical data in Hefei in 1986, the researchers calculated that the male and the female population would become"the ageing one"in 1995 and in 1991 respectively and the latter group was four years earlier than fath of the former one.

根据合肥市1986年死亡资料的数据进行预测,男性约1995年进入"老年人口型",女性约1991年比男性提前4年;在生育水平不变条件下,40岁以上各年龄组死亡率明显降低(如降低50%)对人口老化有促进作用,可提前1年左右。

Problems such as unimplemented construction plans, lowquality construction and poor sanitary conditions in rural roads are found in the course of investigation and research in 26 villages of 20 towns and townships of Baota District, Yanan City. These are because of the weak economic basis on the one hand and the poor administration work in construction planning on the other.

近十多年来,延安市宝塔区的村镇建设,特别是农民住宅、公共建筑和生产建筑的建设基本上适应了农村改革、开放的需要,这对调整农村产业结构、发展商品经济、改善农民的居住条件起到了重要的促进作用,并取得了一定的成绩,积累了丰富的经验。

Their chaperone function is independent of and has promoting effects on the enzyme activities for the formation of disulfide bonds.

它们的分子伴侣功能独立于二硫键形成酶的活性并且对二硫键形成酶活性具有明显的促进作用

The research work of ADP methods is in a primary stage. The works in the dissertation will be helpful to the research of ADP and its applications, as well as its development.

近似动态规划方法的研究还处于初始阶段,本文的工作丰富了这类方法的理论和应用实现,相信将会对于其进一步研究和发展起到有益的促进作用

Methods The milk volume, morphology of mammary gland, serum prolactin level and pituitary acidophil number in lactation rats and the growth improvement in suckling mice were observed after administrating various dosages of Maidang Rutong Granules to lactation rats by gastric gavage .

方法哺乳期大鼠灌胃给予不同剂量的麦当乳通颗粒后,观察其泌乳量、乳腺组织形态、血清泌乳素水平和垂体嗜酸性细胞数量的变化,以及对乳鼠生长的促进作用

Objective It is to explore the promotion effect of integrated traditional Chinese and western medicine therapy on immune function of the patients infected with Coxsackie virus recover.

目的探索中西医结合疗法对柯萨基病毒感染者免疫功能恢复的促进作用

Therefore, F.C.U was not only an educational organs which made historical contributions to contemporary and modern education in Fukien, even in China, but also she was a garden of coordinating Chinese culture with western culture, promoting the Chinas social development and the progress of human society.

因此,福建协和大学不仅是一所教育机关,为福建近现代教育乃至中国近现代教育做出了应有的历史性贡献,更是一所中西文化&协和&的园地,对中国社会的发展和人类社会的进步产生了积极而重大的促进作用

Inthe paper the dynamics of bubble collapse is used to explain the noise spectra of NACA foil.

作者希望本文的工作会对国内空化噪声机理研究起到一定的促进作用

The rate enhancement in homogeneous Suzuki reaction by Lewis acid has been investigated.

研究了Lewis酸在Suzuki反应中的促进作用,考察了Lewis酸、溶剂及碱性试剂对目的产物收率的影响,并优化了反应条件。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力