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For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Note that the precise semantics of text mode on the Macintosh depends on the underlying C library being used.

需要注意的是Mactiontosh 平台上的文本模式依赖于其使用的底层C库。

Thus far, if you see 0 or 1, you can't depend on the value having any meaning.

到目前为止，如果你看到0或1，您可以不依赖于价值有任何意义。

Phagocytosis took an important role in the immune protection. Phagocytosis was not related with serum titre in body.

实验证明这两种抗原具有刺激机体产生免疫保护的作用，吞噬能力的增强是免疫保护的一个因素，吞噬能力不依赖于抗体产生的水平。

Davidson's contention is that our ability to understand the utterances of a language can best be explained by reference to a Tarski-style theory of truth. In terms of such a theory, one's ability to understand an utterance is tied to one's knowledge of its truth conditions.

Davidson的论点是：我们有能力理解语言的表达utterances，能被最佳解释，通过引入真之Tarski模式理论，根据这样的理论，某人理解的能力依赖于对真性条件的知识。

To a large extent the development of the state relies on that of education.

国家的发展在很大程度上依赖于教育的发展。

Toboggan algorithm is an important tool to image segmentation,and the result of image segmentation depends on how to compute the gradient image to a great extent if applying toboggan to it.

滑降算法是一种重要的图像分割工具，然而基于滑降算法的图像分割在很大程度上依赖于待分割图像梯度的计算。

Tonality depends on the reflected brightness of the terrain and can be electronically measured.

色调依赖于地质体反射的亮度，利用电子设备可以测量出来。

A new group of autocorrelation topological index (At、Bt、Ct and Dt) was designed and developed based on the vertex degree of molecular topology and autocorrelation function of mathematics. The autocorrelation functions were calculated from the square root of the vertex degree、modified vertex degree and their combination, that is d i、、 and . The matrix description method and the algorithm of computer software have been developed for the new topological index calculation.

针对目前自相关拓扑指数的计算完全依赖于实验参数而存在的问题，以分子拓扑学点价和自相关函数研究为基础，将点价、修正点价及其组合：、、、的平方根分别作为自相关函数中的f，设计开发出一组新的以点价计算为基础的自相关拓扑指数At、Bt、Ct和Dt。

This is dependent on tourism resources and extend out to the main tourist resort tourism real estate.

这是依赖于旅游资源，扩大了主要的旅游度假胜地的旅游房地产。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。