使成熟

Then she put upon her the white frock that Tess had worn at the clubwalking, the airy fullness of which, supplementing her enlarged coiffure, imparted to her developing figure an amplitude which belied her age, and might cause her to be estimated as woman when she was not much more than a child.

苔丝一头蓬松的头发，配上身上穿的宽大袍子，使她正在发育的身体透露出一种成熟来，让人看不出她的实际年龄，也许会错误地把她当成一个成熟的妇人，而其实她比一个孩子大不了多少。

Being a microcosm himself, he discovers — and it is a true discovery, and he is the man to make it — that the world has been eating green apples; to his eyes, in fact, the globe itself is a great green apple, which there is danger awful to think of that the children of men will nibble before it is ripe; and straightway his drastic philanthropy seeks out the Esquimaux (16) and the Patagonian,(17) and embraces the populous Indian and Chinese villages; and thus, by a few years of philanthropic activity, the powers in the meanwhile using him for their own ends, no doubt, he cures himself of his dyspepsia, the globe acquires a faint blush on one or both of its cheeks, as if it were beginning to be ripe, and life loses its crudity and is once more sweet and wholesome to live.

他是大千世界里的一个缩影，他发现，这是一个真正的发现，而且是他发现的，——世界在吃着青苹果；在他的眼中，地球本身便是一只庞大的青苹果，想起来这却很可怕，人类的孩子如果在苹果还没有成熟的时候就去噬食它，那是很危险的；可是他那狂暴的慈善事业使他径直去找了爱斯基摩人、巴塔哥尼亚人，还拥抱了人口众多的印度和中国的村落；就这样由于他几年的慈善活动，有权有势者还利用了他来达到他们的目的，无疑他治好了自己的消化不良症，地球的一颊或双颊也染上了红晕，好像它开始成熟起来了，而生命也失去了它的粗野，再一次变得又新鲜又健康，更值得生活了。

Vg could be detected in haemolmph of the water—fed female at 48h after eclosion, too.

用10％的蜂蜜和清水分别饲喂两组成虫(简称"蜜组"和"水组")，以研究成虫期的营养对Vg发生和卵巢发育的影响，结果显示，成虫期营养对于Vg的启动合成并不起关键的决定性作用，两组成虫均可以在羽化的48小时检测到Vg，且水组中的血淋巴水平并不低于蜜组对照，但绝大多数水组个体的卵巢发育停留在卵黄沉积的某一时期，此时在血淋巴中也检测不到，只有约20％的饲水个体卵巢可以发育成熟，出少量卵；用高剂量的ZR515于羽化当日点滴处理饲水个体，可以使所有接受处理的饲水个体的卵巢发育成熟，但是产卵〓依旧低于对照组的，不能恢复正常；这说明成虫期营养对卵巢中全体卵母细胞的成熟是必需的，其作用的产生是通过内分泌系统途径实现的。

The development of innovation is the process from juvenility to mature through the activity about learning, hunting and selecting.

创新的发展过程总是由不成熟到成熟，通过创新者与用户交互作用下的学习、搜寻和选择活动，不断改善，使之趋于成熟。

If passion is converted, wife can become mother. If a letch is surpassed, sex can become love. Only sexual energy can mature into the power of love. But we make humans full of hostility toward sex. As a result, love cannot develop from sex.

如果热情被转变，妻子可以变成母亲，如果色欲被超越，性可以变成爱，只有性能量可以成熟而转变成爱的力量，但是我们使人充满了对性的敌意，结果爱变得无法成熟发展。

The porine is the polyembryony animal, many obtains the ovocyte from the porine ovary although but the maturity quite to be low; Because the ROSI technology is does not have to grow the mature sole round sperm cell to pour into directly completely in the ovicell nature, jumped over the spermatozoon in to pass through the physiology and the biochemistry, if the ovicell nature mature or the activation degree were insufficient, added the round immature sperm cell maturity quite inferior reason, very possibly Causes the ROSI micro fertilization defeat.

猪是多胎动物，从猪卵巢上获得的卵母细胞数量虽然较多，但成熟度比较低；由于ROSI技术是将没有完全发育成熟的单一圆形精细胞直接注入卵胞质内，跳越了精子在穿过透明带和卵质膜等过程中所发生的生理和生化反应；如果卵胞质成熟或活化程度不够，加之圆形未成熟精细胞成熟度比较差等原因，很可能造成ROSI受精的卵母细胞内部激活因子蓄积减少和生成不足，引起精核解聚困难、精圆核不能形成、第二极体不能排出、卵母细胞孤雌发育率增加等，使ROSI显微受精失败。

Until recently, the convergence of the Rosen"s arithmetic has been proved. The projection gradient method is the generalization of Steepest decent method to constraint problem. So it does have a faster convergence speed that the fastest decent method . To solve the problem, many researchers have generalizat the well-developed optimization with unconstraint to the Rosen"s gradient method. The conjugate gradient method is one of success to solve the problem.

投影梯度法是最速下降法对约束问题的推广，因此没有较快的收敛速度，为了解决这个问题很多中外学者把发展得比较成熟的无约束最优化算法作类似的推广，其中共轭梯度方法是近年发展的很成熟的方法，它具有计算简单，算法结构好，计算量少，具有良好的收敛性等优点，而Rosen投影梯度法的提出使寻找下降方向变得简单。

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

Methods: Adherent cells were isolated from peripherial blood samples in asthmatic patients in remission and in healthy volunteers by Ficoll and noncontinuous density gradient centrifugation and were cultured with GM-CSF and IL-4 as immature DC.

分别取缓解期哮喘患者和正常人外周血经Ficoll和不连续密度梯度离心法获取贴壁细胞，经GM CSF和IL 4体外培养为不成熟DC ，加入LPS刺激使其发育为成熟DC。

LH plaies a role to delay the occurrence of germinal vesicle, prolong the maturation duration of cytoplasm, enhance the nuclear and cytoplasm synchronization of ovine oocytes matured in vitro, and finally improve the potentiality of their in vitro development.

LH可能通过延迟生发泡破裂和促进胞质成熟的方式，使绵羊卵母细胞的核质成熟趋于同步，有助于绵羊卵母细胞的体外成熟以及受精后的进一步发育。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。