使刺激的

RESULTS: Compared with control group, the activity of the LDH/ACP/Arg in the AMФ or PMФ and in the culture fluid of the AMФ or PMФ were significantly increased (P.05 or P.01), and the ability devouring neutral red and stimulating index in the PMФ were strengthened (P.01), the ergastoplasm was hyperplasia and the amount of lysosome was manifold in the spleen macrophages of old rats induced by paecilomyces cicadidae total polysaccharides.

结果：蝉拟青霉总多糖使老龄大鼠肺泡巨噬细胞、腹腔巨噬细胞胞内和细胞培养上清液内ACP、LDH、arginase活力显著高于对照组（P.05或P.01）；使PMФ的吞噬功能及其刺激指数显著高于对照组（均P.01）；使老龄大鼠脾脏细胞胞质粗面内质网和溶酶体数量多于对照组。

Cd〓 (1, 10, 100, 1000μM) stimulated directly GtH secretion from pituitary of common carp in vitro, with the highest GtH secretion at 100μM, GtH secretion stimulated with 1000μM Cd〓 was not higher than that stimulated with 100μM Cd〓.The antagonism between Ca〓 and Cd〓 in perfusion of the pituitary fragments was not obvious.After being preperfusion with 100μM Cd〓(with or without Ca〓), the GtH secretion of the pituitary fragment was irresponsive to 2-min pulse stmulation of 10μM sGnRH-A.

鲤鱼脑垂体碎片离体灌流孵育实验结果显示，Cd〓（1，10，100，1000μM）可直接刺激鲤鱼脑垂体分泌GtH，灌流液中Ca〓对Cd〓的拮抗作用不明显，100μM Cd〓刺激脑垂体分泌GtH达到高峰，Cd〓浓度增加到1000μM时，脑垂体分泌GtH并没有进一步增加，甚至有减少的趋势；100μM Cd〓预灌流脑垂体后，可使脑垂体对2-min 10μM sGnRH-A刺激的反应性消失；1.25mM的EDTA可消除100μM Cd〓刺激脑垂体分泌GtH的作用；TFP和Cd〓同时灌流脑垂体一段时间后，撤除TFP可使脑垂体分泌GtH显著增加，即出现"反跳"现象。

The frequency of spontaneous UP/DOWN transitions could be entrained to a regular interval by repetitive sound stimuli with intervals ranging 3-12 sec, in which each sound stimulus effectively induced a UP-to-DOWN transition.

外界声音刺激（白噪声，0.1-35 KHz）能调制神经元自发的高电、低电位期的传递节律：当声音刺激落在高电位期时，每一次声音刺激都会使细胞膜电位由高电位期向低电位期转变，并当声音刺激间隔在3-12秒范围内时，自发的高、低电位期的转变节律就同步于声音刺激的重复率，即跟随效应。

Methods for the control of vocal fold vibration in anesthetized dogs by superior laryngeal nerve electrical stimulation, recurrent laryngeal nerve electrical stimulation and the adjustment of glottal air flow rate with stroboscope and the multifunetion glottograph developed by authors were studied.

本文借助于喉动态镜和作者研制的多功能声门图仪研究了在麻醉状态下，犬喉神经用电刺激的同时，调节声门气流使声带振动的方法；摸清了声门气流、喉上神经与喉返神经受电刺激的变化对声带体振动的影响；同时用电刺激喉上神经与喉返神经模拟了几种喉麻痹。

To those persons who are out of the nerves control, we use FES to generate electrical stimulation and make use of the nerve cells'response to these stimulations to transfer our artificial controlling signals. Through the stimulation of adscititious electrical current, nerve cells are supposed to generate a nerve impulse that is the same as the one induced by natural inspiration.

对于失神经控制的患者，可以采用功能性电刺激仪(Functional electrical stimulation FES)产生电刺激，利用神经细胞对电刺激的响应来传递外加的人工控制信号，通过外电流的作用使神经细胞能产生一个与自然激发引起的动作电位完全一样的神经冲动，使其支配的肌肉纤维产生收缩，从而获得运动的效果。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

The basic procedures of the experiments were:(1)rule training:thisis pretraining in order to make subjects attend gradually to the numberdimension of stimuli,and master the rule of number matching.(2)formaltraining:a variety of cards loading number"3"or"5"served as samplesand comparisons.(3)transfer test,test trials were interposed among usualtraining trials of each session,the number is from 1 to 9,and three typestransfer test were proceeded.

两个实验的基本程序为：（1）规则训练阶段：用几个步骤使被试逐渐注意刺激的数维度，并掌握数目匹配原则；（2）正式训练阶段：数目3、5的多种变式作为样本和比较刺激，通过被试在各种样本和比较刺激对上的反应分析它们所利用的线索；（3）迁移测试阶段：将迁移测验随机插入每天的正式训练中，数目扩展为1至9，以验证被试数能力的抽象程度。

The accomplished software-control system of cellular growth system based on direct current-stimulation has characteristics as below:(1)individualise treatment according to user's requirements such as stimulation-current , stimulation-time and stimulation-channel;(2) operate easily and conveniently based on friendly;(3) could enable cursor switch conveniently and quickly among input frames, and disable corresponding choices to avoid mistaken operation;(4)could analyze the gained data and display the waveform of analytical data;(5)provide set up program of the software.

已完成的细胞直流电刺激实验系统软件控制系统具有以下特点：(1)可根据用户需求选择刺激电流的强度、刺激时间和刺激的通道，同时还可对采样频率进行选择；(2)系统软件操作界面友好、美观；(3)参数设置时控制按钮的光标可以方便、快速地在各输入框间切换，并使不能操作的选项失效，减少误操作；(4)对采集到的特征数据可进行数据分析，并对分析数据进行波形显示；(5)提供了该软件的安装程序。

The characteristics of on-off responses of medial geniculate body neurons to tone bursts of varying frequency, intensity and duration were affected by lateral amygdaloid nucleus stimulation, which was in form of altering the pattern of discharge or complete suppression. The effect also varied with the changes of the interval between amygdaloid stimulation and the tone bursts. The results of the present work show that LAm could modulate temporal processing of auditory information.

新西兰兔内膝体神经元的on-off反应与纯音刺激的强度、频率及作用时程有关；刺激边缘系统杏仁外侧核，可以抑制on-off反应，或是使on-off反应放电构型发生变化。on-off反应是神经元对声音信号作用时程及声音的起止进行编码的方式之一，LAm对on-off反应的影响表明，边缘系统杏仁体的活动可以调控听觉中枢对声音时间信息的编码。

Uh Uh, uh, huh Yo, yo Drop your glasses, shake your asses Face screwed up like you having hot flashes Which one, pick one, this one, classic Red from blonde, yeah bitch Im drastic Why this, why that, lips stop askin Listen to me baby, relax and start passin Expressway, hair back, weavin through the traffic This one strong should be labeled as a hazard Some of yall niggas hot, sike Im gassin Clowns I spot em and I cant stop laughin Easy come, easy go, E-V gon be lastin Jealousy, let it go, results could be tragic Some of yall aint writin well, too concerned with fashion None of you aint gizell, cat walk and imagine Alotta yall Hollywood, drama, passed it Cut bitch, camera off, real shit, blast it And if I had to give you up Its only been a year Now I got my foot through the door And I aint goin nowhere It took awhile to get me in And Im gonna take my time Dont fight that good shit in your ear Now let me blow ya mind They wanna bank up, crank up, makes me dizzy Shank up, haters wanna come after me You aint a ganster, prankster, too much to eat Snakes in my path wanna smile up at me Now while you grittin your teeth Frustration baby you gotta breathe Take alot more that you to get rid of me You see I do what they cant do, I just do me Aint no stress when it comes to stage, get what you see Meet me in the lab, pen and pad, dont believe Huh, sixteens mine, create my own lines Love for my wordplay thats hard to find Sophomore, I aint scared, one of a kind All I do is contemplate ways to make your fans mine Eyes bloodshot, stressin, chills up your spine Huh, sick to your stomach wishin I wrote your lines And if I had to give you up Its only been a year Now I got my foot through the door And I aint goin nowhere It took awhile to get me in And Im gonna take my time Dont fight that good shit in your ear Now let me blow ya mind Let your bones crack Your back pop, I cant stop Excitement, glock shots from your stash box Fuck it, thugged out, I respect the cash route Locked down, blastin, sets while I mash out Yeah nigga, mash out, D-R-E Back track, think back, E-V-E Do you like that, you got to I know you Had you in a trance first glance from the floor too Dont believe Ill show you, take you with me Turn you on, pension gone, give you relief Put your trust in a bomb when you listen to me Dancin much, get it all?

Uh Uh ， uh，哼！ Yo， yo 降低你的眼镜，摇动你的驴脸振作起来像你有热的闪光哪一个，精选一，这一个，古典作品红色的从金发碧眼的女人，是的母狗 Im 激烈的为什么这，为什么那，唇停止 askin 听我的话宝贝，放松而且开始 passin 高速道路，头发背面，透过交通的 weavin 这一个强壮的应该被贴标签为危险一些 yall niggas 热的， sike Im gassin 我弄脏 em 的小丑和我讲黑话停止 laughin 易得易失，电子 V gon 是 lastin 妒忌，让它去，结果可能是悲惨的一些 yall aint writin 很好地，太关心的由于流行你没有一个 aint gizell，猫走而且想像 Alotta yall 好莱坞，戏剧，通过了它削减母狗，照相机走开，真正的粪，摧残它而且如果我必须放弃你它的唯一是一年现在我使我的脚通过门而且我无处的 aint goin 它一会儿拿让我获得录取而且 Im 去从容不迫 Dont 在你的耳朵中对抗好粪现在让我吹 ya 思想他们想要存入银行在，上面曲柄提高，使我晕眩胫向上，憎恨者想要跟随我你 aint ganster，玩皮的人，太很多的吃在我的路径的蛇想要仰头对我笑现在当你的时候 grittin 你的牙齿挫折纵容你必须呼吸带 alot 更多你免除我你见到我做他们所讲黑话的做，我仅仅做我 Aint 没有压迫力当它来举行的时候，拿你见到的在实验室，钢笔和填补中遇到我， dont 相信哼！，十六我的，产生我自己的线为我的文字的争论爱那难者找二年级学生，我 aint 惊吓，一类型全部我做是注视方法使你的狂热者成为我的眼睛充血的， stressin，寒冷在你的背骨上面哼！，你的胃 wishin 的病人我写了你的台词而且如果我必须放弃你它的唯一是一年现在我使我的脚通过门而且我无处的 aint goin 它一会儿拿让我获得录取而且 Im 去从容不迫 Dont 在你的耳朵中对抗好粪现在让我吹 ya 思想让你的骨头裂缝你的背部取出，我讲黑话停止刺激， glock 注射从你的藏起来盒子性交它，宗教性暗杀团员出，我尊敬现金路径锁了下来， blastin ，组当我调情出的时候是的 nigga，调情出， D-R-E 支持轨道，向后地想，电子 V-E 做你相似的，你到达我认识你也在来自地板的梦幻之境第一一瞥中有了你 Dont 相信生病的表演你，和我带你把你打开，发给退休金离去，给你减轻当你听我的话时候，把你的信赖放入一个炸弹 Dancin 很多，拿它全部？

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了