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Objective: The purpose of our studies are gaining a better insight into the effect of genistein on mesangial cell"s phenotype change and ECM expression plus degradation under DN circumstances.We add genistein with different concentrations in high glucose cultured rat mesangial cells;feed DM rats with the single concentration genistein for different days;to explore the expression of SMemb,the mark of mesangial cell"s hypertrophy phenotype change;to examine the synthesis of Fn as well as the change of the balance between MMP-2 and TIMP-l;to comprehend its effect on renal pathological changes of DM rats and some related factors;trying toexplore the possible mechanisms.Through these studies,we will have some information about the experimental value of genistein in DN field.

目的:为了研究金雀异黄素对DN环境下大鼠MC肥大表型转换标志物SMemb和ECM分泌及降解的影响,我们拟在细胞水平以不同浓度的金雀异黄素作用于高糖培养下大鼠MC,在动物水平以同一浓度的金雀异黄素作用于DM大鼠不同时间,观察细胞表型转换标志物SMemb、ECM主要成分Fn、ECM降解酶系统基质金属蛋白酶—2(MMP-2)/基质金属蛋白酶抑制剂—1(TIMP-1)表达的变化,同时观察金雀异黄素对DM大鼠肾脏病理及影响肾脏病进展的糖脂代谢紊乱的影响,并进一步探讨金雀异黄素发挥作用的可能机制;为明确金雀异黄素在DN治疗中的地位及意义提供实验依据。

The frontogenesis process involves in the interactions among the systems of multiple scales. Since the hardness of the nonlinear problem, it is difficult to study frontogenesis analytically. The introduction of the effects of orography, friction and diabatic processes generally makes impossible the analytical resolution of the problem and leads to the use of numerical models. Primitive equations are numerical integrated together with a detailed description of physical processes. The circulation obtained is then used to diagnose and test theoretical mechanisms. It should be noted, however, that a fully description of frontogenesis in explicitly resolving the of large-, meso- and micro-scale flow in the same framework is not yet possible because of the excessive computer capacity and the time required. In order to deal with the problem, the action of large-scale background has been simplified and taken into consideration through the addition of the forcing into the nonhydrostatic cloud model.

大气锋生是一种多尺度相互作用的过程,理论研究遇到非线性的困难,在考虑地形、摩擦、非绝热等物理过程之后,解析研究更加棘手,通过数值模拟搞清其中的物理机制是重要的研究手段,但是把大、中、小尺度甚至微尺度的系统及其相互作用过程在一个模式里同时模拟好仍然受计算机速度和容量的限制,本论文在非静力云模式中通过强迫方式加入大尺度变形场的作用,在考虑到大尺度背景作用的同时,可以充分利用云模式所提供的丰富物理过程、非静力和高分辨率特点,开展一些过去较难进行的研究工作。

A rotary dobby which includes pivoting arms which are moveable with respect to a plate connected to an element for actuating a heddle frame in controlled response to a reading-in device and wherein the pivot arms include catches which are uniquely configured having internal and external bearing surfaces which cooperatively engage binding surfaces of the plate. The rotary rat trap mechanism includes an oscillating section (4) at the blade level, coupled to the warp frame (6), and associated with an actuator (2) mounted freely on the main shaft (1) of the mechanism.

织机用旋转式多臂机构,包括在综片的水平位置,一个连接综框(6)和驱动元件(2)的摆动元件(4),驱动元件(2)装于上述多臂机构的主轴(1)上,一个靠在与驱动元件横向固结在一起的盘片(3)上的可移动连接元件(8),该移动机构受控于弹性装置(10),它可有效地将上述盘片(3)与紧固于上述主轴(1)的驱动盘(7)角连接在一起,以及两个一面受穿经装置(16)作用,一面受弹性装置(13)作用的绞支转臂(11)。

Should know this correctly in the round " invisible hand ", should from the analysis it is in between hoggish heart of the person and altruistic heart on the foundation of the bridge that removes and intermediary action, announce its place accumulate contained ethical value, discuss deep then " invisible hand " the great effect that has to market economy grows and perfecting place.

要全面正确地认识这只"看不见的手",就应该从分析它在人的利己心和利他心之间所起的桥梁和中介作用的基础上,揭示其所蕴含的伦理价值,进而深入探讨"看不见的手"对于市场经济发展和完善所具有的伟大作用。

The degradating and redistributing of ECM were migration of VSMC and vascular remodeling through inhibiting the production of PDGF-BB and the activation of MMPs so to prevent the vascular stenosis.⑤Orthotopic hybridism in situ: The expression of MMP-3 increased after operation, the tendency and intensity were parallel to the expression of NF-κB. Tongxinluo could decrease the expression of MMP-3 and NF-κB. The study showed that the producting and activating of MMP-3 were modulated by NF-κB. The inhibition to the producting and activating of MMp-3 of Tongxinluo was mediated by inhibiting the activating of NF-κB. Conclusion ①The rabbit vascular stenosis model could be established successfully by plain balloon damage, the operation process was easy, economical and practical.

①单纯球囊损伤可成功建立典型家兔血管狭窄模型,操作方法简单,经济实用;②以VSMC增殖、迁移为主的内膜增厚以及以ECM降解、合成与再分布所致的血管重构是导致受损血管狭窄的根本原因;③通心络能明显抑制VSMC的增殖、迁移和ECM降解、合成,阻止血管内膜增生和血管重构,防止受损血管狭窄;该作用可能与其减少和阻止PDGF-BB的产生和活性,以及抑制MMPs的表达和恢复MMPs/TIMPs平衡有关;④通心络能显著抑制球囊损伤后血管内膜增生和血管重构,可能与其保护血管内皮,改善内皮功能,增加血清NO含量有关;⑤通心络抑制内膜增生和血管重构,减轻受损血管狭窄,还可能是通过抑制NF-κB的活化途径而起作用的

STUDY SELECTION: The data were selected firstly to find out those about the pharmacological mechanism of the effect of Ginkgo biloba extract on brain tissue and neural cells, clinical application, the protective effect of its active components on cerebral ischemic hypoxia and hydrops, and the prevention of Parkinson's disease caused by memory lost of the cerebral cortex and pathological changes of brain.

资料提炼:共收集到44篇关于银杏叶提取物对脑组织及神经损伤保护作用的文献,纳入为银杏叶提取物作用于脑细胞及神经细胞的相关药理机制,临床运用及其有效成分,对脑缺血缺氧,水肿的保护以及大脑皮质的记忆功能丧失和脑部病变引起的帕金森病的防治相关的文献19篇。

The daily life and art are inclining to integrate, which has reversed the traditional concepts of art aesthetic.

本文通过对哲学家杜威的美学理论:"艺术即经验"的分析入手,引用一些具体的,不同时期的艺术作品的分析比较,探讨日常生活的经验在艺术活动中的作用和状态,艺术与生活的联系,以及对艺术经验与日常生活经验之间的连续性和交互作用的认识。

Migration of radioactive nuclides in groundwater of porous media is controlled not only by groundwater hydraulics, but also by many other physical, chemical processes. Nuclides transport model coupled chemical equilibrium action is to join convection-dispersion model and multicomponent chemical equilibrium model, it is different from traditional transport model based on K〓 completely in theory.

地下水中核素在多孔介质的迁移过程不仅受到水动力的控制,还受到多种物理化学作用的影响,耦合平衡化学作用的核素迁移模型就是把对流—弥散模型与多组分化学平衡模型有机地结合起来,这种模型与传统的基于K〓值的核素迁移模型在理论上是完全不同的。

Various inorganic acid, such as ammonium chloride, copper sulfate, aluminum sulfate, mercury chloride, cerium sulfate and cerium chloride, have been evaluated for copper powder, zinc powder, or tin powder-mediated allylation reactions of carbonyl compounds with allyl bromide in aqueous medium.

结果表明:在同样的反应条件下,与铜粉或锌粉作用的此类反应相比,锡粉能更好的作用羰基烯丙基化反应,并且该反应的产率都比较高;在同样的金属促进剂存在下,硫酸亚铈的促进性能是所有无机酸中最好的。 2、研究了二氧化碳促进羰基化合物烯丙基化反应。

By integrating the multi-discipline methods of petroleum geochemistry, sedimentology, hydrogeology, petroleum geology and experimental geochemistry, the thesis has carried out experiments of microcline dissolution in solutions with organic acids, crude oil, brines with high total dissolved solids , and has dealt with Al distribution between the crude oil and the brines after the experiments.

综合利用油气地球化学、沉积学、水文地质学、石油地质学、实验地球化学多学科交叉方法,进行了长石在有机酸、原油、高矿化度卤水中的溶解实验,研究了溶解后元素Al在油水相中的分配;通过详细研究塔里木盆地塔中地区、和田河气田、库车坳陷和塔北隆起北部油气藏流体的化学、同位素组成,观察岩石薄片、测试流体包裹体成分和均一化温度、全岩和自生矿物同位素组成,并结合油气运移和成藏史的研究成果,分析了三地区流体的成因、流动,并探讨了烃类侵位对成岩作用的影响、微生物和热化学的硫酸盐还原作用。

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推荐网络例句

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。