作用于血管的

AS impairs EC function by inhibiting hsp90 associated with eNOS to uncouple eNOS activity and alter the balance of NO and O2.-, which may be the mechanism of AS as an antiangiogenic and antineoplastic agent. Our findings may provide theoretical evidences for AS clinical practice in the future.

结论AS可以阻止hsp90与eNOS结合，使eNOS非偶联，破坏NO与O.2-的平衡，从而损伤内皮细胞功能，这可能是AS抗血管生成和抗肿瘤作用的机理，为将来AS应用于临床提供理论依据。

More and more evidences have shown that traditional high 〓 cardioplegic solutions increase energy and oxygen demand during asystole; make more calcium entry into cells.

愈来愈多的研究表明：传统高〓心肌保护液于诱导心脏停搏期间增加心肌能耗、氧耗，介导〓内流并对传导系统抑制作用相对较弱，高〓所致的血管内皮细胞损伤也引起学者们的高度重视，如何减轻或避免高〓心肌保护液的不利影响，是心外科领域中一个亟待解决的难题。

Aside from pancreatic enzymes activiation and autodigestive process, recent investigations have established that the upregulation of inflammatory mediator are believed to be the critical steps in the progression of mild pancreatitis to severe pancreatitis. Tumor necrosis factor-, ThyomboxaneA2 ,ProstaglandinsI2 are all important inflammatory mediator. TNF-( is one of cytokines. It is important to the over-production of ICAM-1,VCAM-1, TXA2 andPGI2. The ICAM-1 and VCAM-1 mediate both leukocytes adhesion and migration through the endothelium into tissues to connect with injuried target cells. The TXA2 and PGI2 are the production of arachidonic acid. They are responsible for the tissue ischaemia.

肿瘤坏死因子（Tumor necrosis factor-， TNF-、血栓素A2（ThyomboxaneA2，TXA2），前列环素（ProstaglandinsI2，PGI2）均是炎症反应中重要的炎性介质，其中肿瘤坏死因子-是非常重要的细胞因子之一，它由活化的单核细胞产生，在细胞间黏附分子（Intercellular adhesion molecule-1，ICAM-1）及血管细胞黏附分子(Vascular cell adhesion molecule-1，VCAM-1的表达、血栓素A2及前列环素过量生成方面起着重要的作用，前两者是介导白细胞与内皮细胞黏附，迁移于组织并与受损的靶细胞相结合的主要媒介，是炎症反应中的重要介质，后两者是花生四烯酸的代谢产物，亦是重要的炎性介质，参与构成血液循环障碍。

SI could abolish the effect of L-NMMA on vasomotion but L-NMMA did not influence the effect of SI on vasomotion.

在L—NMMA的有效作用时间内应用SI可使被抑制于收缩状态的血管重新扩张。

The data suggest that ETX directly trigger the release of CGRP from capsaicin-sensitive sensory nerve innervating blood vessels.

结果提示：内毒素直接刺激血管周围对辣椒素敏感的感觉神经释放CGRP，这一作用依赖于细胞外钙，并且对钌红敏感的机制。

Part Three: Application of the Abnormal Beckmann Rearrangement to the Total Synthesis of the Natural Product Fumagillin Fumagillin is a natural product with efficient antiangiogenesis activity.

Scheme 2 〓三、将非正常Beckmann反应尝试应用于天然产物Fumagillin及衍生物的全合成 Fumagillin是一个具有高效抗新生血管作用的天然产物。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失