作用于血管的

Tumstatin is the fortest antiangiogenesis factor in present, its effect is more than 10 times as endodermis chalone.

肿瘤抑素是目前发现的最强的血管生成抑制因子，作用强于内皮抑素10倍以上。

To examine the microvascular actions of tanshinone IIA researchers applied it topically to the hamsters' cheek pouch or mice cremaster muscles to achieve the final concentration of one μg/ml or five μg/ml. After the application of tanshinone IIA, the experiment was continued for an additional 60-minute period in order to measure arteriolar diameter and peri-arteriolar nitric oxide concentration.

为研究丹参酮ⅡA对微血管的作用，研究者将丹参酮ⅡA应用于金仓鼠颊囊以及小鼠睾提肌使局部血管内药物浓度达到1μg/ml和5μg/ml，实验继续进行60分钟后测量微动脉管径及外周微动脉中一氧化氮浓度。

To examine the microascular actions of tanshinone IIA researchers applied it topically to the hamsters' cheek pouch or mice cremaster muscles to achiee the final concentration of one μg/ml or fie μg/ml. After the application of tanshinone IIA, the experiment was continued for an additional 60-minute period in order to measure arteriolar diameter and peri-arteriolar nitric oxide concentration.

为研究丹参酮ⅡA对微血管的作用，研究者将丹参酮ⅡA应用于金仓鼠颊囊以及小鼠睾提肌使局部血管内药物浓度达到1μg/ml和5μg/ml，实验继续进行60分钟后测量微动脉管径及外周微动脉中一氧化氮浓度。

In addition to β cells,GIP receptor is also expressed in various tissues including stomach, small intestine, adipose tissue, adrenal cortex, pituitary body, bone, vascular endothelial cells and brain.

而许多研究证实GIP受体分布广泛，除分布在胰腺β细胞外，还分布于胃、小肠、脂肪组织、肾上腺皮质、心脏、肺、垂体、骨、血管内皮细胞和脑组织的一些区域等，在这些组织中发挥重要的作用。

The major results obtained are: PCR-RFLP method is suitable for molecular identification of Shihu; 205 compounds were isolated from 10 species of Dendrobium, including 21 new compounds, and 28 compounds isolated from genus Dendrobium for the first time. Each of the extracts and compounds were screened for anticoagulant and antitumour activities separately. The results indicated that the ethyl acetate extract from Dendrobium chrysanthun has significant anticoagulant function; the antitumour function of the 4 bibenzyl components from Dendrobium chrysotoxum is stronger than that of phenanthrene, of which the erianin has significant anti-angiogenic effect both in vivo and in vitro; components with moderate or stronger antitumour activities were found in the extracts of D. thyrsiflorum, D. chrysanthun and D. trigonopus; quality standard for 5 species of Dendrobium was drawn up use active or indicative components as control.

重要研究结果有：经方法学研究，认为PCR-RFLP法适于作为石斛属药材分子标记鉴定方法；对10种石斛进行化学成分分离鉴定，共分得205个化合物，其中新化合物21个，首次从石斛属分得的28个；对提取物和各单体化合物分别作抗凝血、抗肿瘤等活性筛选，结果说明束花石斛乙酸乙酯部位有显著的抗凝血作用，鼓槌石斛的4个联苄类成分抗肿瘤作用强于菲类，联苄类毛兰素在体内外有显著抗血管生成活性，球花石斛、束花石斛及翅梗石斛均筛到中等或较强抗癌活性的成分；选择有活性或指标性成分作对照品，对5种石斛草拟了质量标准。

The digestion process includes the following steps: adding 0.15 % concentration collagenase II solution compounded with DMEM into blood vessel smooth muscle tissue block and acting in water bath for 1.5 hr until forming floccular tissue; cleaning with 0.02 % EDTA solution, adding 0.125 % trypsase solution and water bath vibrating to digest at 37 deg.c to obtain dispersed smooth muscle cells; terminating enzyme action with 10 % new born ox serum culture liquid; regulating cell concentration with 20 % new born ox serum culture liquid to 50,000-500,000/L, inoculation, and culturing in culture tank with 5 % CO2 and first 37 deg.c to cell fusion of 70-80 %; and subculturing conventionally.

向血管平滑肌组织块中，加入用DMEM配制的0.15％胶原酶II溶液，水浴箱中作用1.5h，至组织呈絮状，用0.02％的EDTA清洗，然后，加入0.125％胰蛋白酶溶液，于37℃水浴振荡消化，即可得到分散的平滑肌细胞，用10％新生牛血清的培养液终止酶的作用。加入含20％新生牛血清的培养液，调节细胞密度为5×104～5×105个/L，接种，放入5％CO2、37℃培养箱中培养。当细胞达到70％～80％融合时即可按常规方法传代。

GA antagonized SMA constriction induced by myricetin. The antagonizing effect on myricetin in shock 1, 2 and 3 hours groups was more obvious than that in the other groups. CONCLUSION :At the early stage after hemorrhagic shock, the endothelium-dependent and independent vascular contractile response show a compensatory increase.

SMA血管环对杨梅黄酮的反应主要表现为：休克0、0.5、1和2 h组明显高于正常对照组，于休克2 h达最高点；休克3 h和4 h组明显低于正常对照组，运用18α-GA阻断MEGJ后，各组血管环的收缩反应性较18α-GA作用前明显下降，其中以休克1、2和3 h组下降幅度明显大于其他组。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用，阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制，我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响；以Lewis肺癌自发性转移为模型，考察了托吡酯对肿瘤生长和转移的影响；同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响；检测了其对血管新生的作用；利用体外AQP1表达模型，研究了CA抑制剂对AQP1功能的影响；此外，用蛋白质组学的关键技术，通过对模型组与托吡酯治疗组血清蛋白质组的比较分析，来寻找与肿瘤转移相关的蛋白质，探索托吡酯的可能作用靶点。

Endothelin, a family of vasoconstrictive peptides, distributes in the cardiovascular system, the actions of which are mediated by ETA and ETB receptors, both present in the myocardium and coronary arteries.

内皮素(endothelin，ET)是一类作用强烈的缩血管肽，主要分布于心血管系统，其生物效应由ET_A及ET_B两种受体介导。

The expression of VEGF protein in glomeruli was detected by immunohistochemistry method.

转载于中国论文联盟 http：//www.lwlm.com 目的研究血管内皮生长因子在先兆子痫大鼠肾损伤中的作用。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失